Abstract
The precursors of both n-6 and n-3 polyunsaturated fatty acids (PUFAs), linoleic acid and α-linolenic acid, respectively, are essential for mammals as they are required for normal physiological function and cannot be synthesized de novo (Holman, 1968). They can only be accumulated by placental transfer or by dietary intake. Once accretion of these fatty acids has occurred, metabolic, conservation and recycling pathways sustain them (Bazan et al., 1994) Unlike mammals, plants can synthesize these precursor PUFAs (linoleic and α-linolenic acids) so they are found in abundance in the chloroplast membranes of plants, in certain vegetable oils, and in the tissues of plant-eating animals (Nettleton, 1991). The best sources of α-linolenic acid are vegetable oils, such as perilla (Yoshida et al., 1993) rapeseed (canola), linseed, walnut, and soybean (Nettleton, 1991). They are also abundant in shellfish, fish, and fish products and can be found in low amounts in green, leafy vegetables and baked beans (Nettleton, 1991; Sinclair, 1993).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson R. Biochemistry of the Eye. American Academy of Ophthalmology, San Fransisco, 1983.
Anderson R, Maude M. Lipids of ocular tissues. VIII. The effects of essential fatty acid deficiency on the phospholipdis of the photoreceptor membranes of rat retina. Arch Biochem Biophysiol 1970; 151: 270 - 276.
Anderson R, Risk M. Lipids of ocular tissues. IX. The phospholipids of frog photoreceptor membranes. Vision Res 1974; 14: 129 - 131.
Anderson RE, Chen H, Stinson A. The accretion of docosahexaenoic acid in the retina. World Rev Nutr Diet 1994; 75: 124 - 127.
Armington JC. The Electroretinogram. Academic, New York, 1974.
Armitage J, Weisinger H, Vingrys A, et al. Perinatal omega-3 fatty acid deficiency alters ERG in adult rats irrespective of tissue fatty acid content. [ARVO Abstract]. Invest Ophthalmol Vis Sci 2000; 41: S245.
Aveldano de Caldironi M, Bazan N. Composition and biosynthesis of meolcular species of retina phosphoglycerides. Neurochemistry 1980; 1: 381 - 392.
Baylor DA, Lamb TD, Yau KW. The membrane current of single rod outer segments. J Physiol 1979; 288: 589 - 611.
Bazan NG, Gordon WC, Rodriguez de Turco EB. Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process. Adv Exp Med Biol 1992; 318: 295 - 306.
Bazan NG, Rodriguez de Turco EB, Gordon WC. Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. World Rev Nutr Diet 1994; 75: 120 - 123.
Bell M, Dick J, Buda C. Molecular seciation of fish sperm phospohlipids: large amounts of dipolyunsaturated phosphatidylserine. Lipids 1997; 32: 1085 - 1091.
Benolken RM, Anderson RE, Wheeler TG. Membrane fatty acids associated with the electrical response in visual excitation. Science 1973; 182: 1253 - 1254.
Bernsohn J, Spitz F. Linoleic and linolenic acid dependency on some brain membrane-bound enzymes after lipid deprivation in rats. Biochem Biophys Res Commun 1974; 57: 293 - 298.
Birch DG, Birch EE, Hoffman DR, et al. Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. Invest Ophthalmol Vis Sci 1992; 33: 2265 - 2376.
Birch DG, Hood DC, Nusinowitz S, et al. Abnormal activation and inactivation mechanisms of rod transduction in patients with autosomal dominant retinitis pigmentosa and the Pro-23-his mutation. Invest Ophthalmol Vis Sci 1995; 36: 1603 - 1614.
Birch E, Birch D, Hoffman D, et al. Breast-feeding and optimal visual development. J Pediatr Ophthalmol Strabismus 1993; 30: 33 - 38.
Bourre J, Durand G, Erre J, et al. Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats. Audiology 1999; 38: 8 - 13.
Bourre J, Faivre A, Dumont O, et al. Effect of polyunsaturated fatty acids on fetal mouse brains in culture in a chemically defined medium. J Neurochem 1983; 41: 1234 - 1242.
Bourre JM, Francois M, Youyou A, et al. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J Nutr 1989; 119: 1880 - 1892.
Breton ME, Quinn GE, Schueller AW. Development of electroretinogram and rod phototransduction response in human infants. Invest Ophthalmol Vis Sci 1995; 36: 1588 - 1602.
Breton ME, Schueller AW, Lamb T, et al. Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction. Invest Ophthalmol Vis Sci 1994; 35: 295 - 309.
Brown KT. The electroretinogram: its components and their origins. Vision Res 1968; 8: 633 - 677.
Brown MF. Modulation of rhodopsin function by properties of the membrane bilayer. Chem Phys Lipids 1994; 73: 159 - 180.
Bui BV, Vingrys AJ. Development of receptoral responses in pigmented and albino guinea-pigs (Cavea porcellus). Documenta Ophthalmol, 2000; 99: 151 - 170.
Bui BV. The development of the electroretinogram in the guinea pig (cavia porcellus) MSc dissertation, University of Melbourne, 1998.
Burr G, Burr M. A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 1929; 82: 345 - 367.
Bush RA, Malnoe A, Reme CE, et al. Dietary deficiency of n-3 fatty acids alters rhodopsin content and function in the rat retina. Invest Ophthalmol Vis Sci 1994; 35: 91 - 100.
Bush RA, Sieving PA. A proximal retinal component in the primate photopic ERG a-Wave. Invest Ophthalmol Vis Sci 1994; 35 (2): 635 - 645.
Chen Y, Houghton LA, Brenna JT, et al. Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. J Biol Chem 1996; 271:20, 507-20, 515.
Chen Y, Saari JC, Noy N. Interactions of all-trans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein. Biochemistry 1993; 32:11, 311-11, 318.
Cibis G, Anderson R, Chew E, et al. Fundamentals and principles of ophthalmology. In: Cibis G, Anderson R, Chew E, et al., eds. Basic and Clinical Science Course. American Academy of Ophthalmology, San Fransisco, 1995.
Cideciyan AV, Jacobson SG. An alternative phototransduction model for human rod and cone ERG a-waves: normal parameters and variation with age. Vision Res 1996; 36: 2609 - 2621.
Clarke SD, Jump DB. Dietary polyunsaturated fatty acid regulation of gene transcription. Ann Rev Nutr 1994; 14: 83 - 98.
Cobbs WH, Pugh EN. Kinetics and components of the flash photocurrent of isolated retinal rods of the larval salamanda, Ambystoma tigrinum. J Physiol 1987; 394: 529 - 572.
Cone RA. Early receptor potential of the vertebrate retina. Nature 1964; 201: 626 - 628.
Cone RA, Cobbs WH. Rhodopsin cycle in the living eye of the rat. Nature 1969; 221: 820 - 822.
Connor WE, Neuringer M. The effects of n-3 fatty acid deficiency and repletion upon the fatty acid composition and function of the brain retina. In: Karnovsky ML, Leaf A, Bolls LC, eds. Biological Membranes: Aberrations in Membrane Structure and Function. Alan R. Liss, New York, 1988.
Connor WE, Lin DS, Neuringer M, et al. The comparative importance of prenatal and postnatal n-3 fatty acid deficiency: repletion at birth and later. In: Sinclair AJ, Gibson RA, eds. The Third International Congress on Essential Fatty Acids and Eicosanoids. AOCS, Champaign, IL, 1993.
Crawford MA, Sinclair M. Nutritional influences in the evolution of the mammalian brain, CIBA Foundation Symposium on Lipids, Malnutrition and the Developing Brain. Associated Scientific, New York, 1972.
Dawson W, Galloway N. Early receptor potential: origin and clinical applications. In: Heckenliveley J, Arden G, eds. Principles and Practice of Clinical Electrophysiolology of Vision. Mosby Year Book, St. Louis, MO, 1991.
Dowling JE. The Retina: An Approachable Part of the Brain. Harvard University Press, Cambridge, MA, 1987.
Dratz EA, Holte LL. The molecular spring model for the function of docosahexaenoic acid (22:6n-3) in biological membranes. In: Sinclair AJ, Gibson RA, eds. The Third International Congress on Essential Fatty Acids and Eicosanoids. AOCS, Champaign, IL, 1993.
Dratz EA, Furstenau JE, Lambert CG, et al. NMR structure of a receptor-bound G-protein peptide. Nature 1993; 363: 276 - 281.
Dudley P, Landis D, Anderson R. Further studies on the chemistry of photoreceptor membranes fed an essential fatty acid deficient diet. Exp Eye Res 1975; 21: 523 - 530.
Faber DS. Analysis of the slow transretinal potentials in response to light. Doctoral dissertation, State University of New York, Buffalo, 1969.
Fliesler SJ, Anderson RE. Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 1983; 22: 79 - 131.
Frishman L, Karwoski C. The d-wave. In: Heckenliveley J, Arden G, eds. Principles and Practice of Clinical Electrophysiolology of Vision. Mosby YearBook, St Louis, MO, 1991.
Frishman LJ, Steinberg RH. Origin of negative potentials in the light-adapted ERG of cat retina. J Neurophysiol 1990; 63: 1333 - 1346.
Fulton AB, Rushton WA. The human rod ERG: correlation with psychophysical responses in light and dark adaptation. Vision Res 1978; 18 (7): 793 - 800.
Fulton AB, Dodge J, Hansen RM, et al. The quantity of rhodopsin in young human eyes. Curr Eye Res 1991; 10: 977 - 982.
Fulton A, Hansen RM, Dorn E, et al. Development of primate rod structure and function. In: Vital-Durrand F, ed. Infant Vision. Oxford University Press, London, 1995a.
Fulton AB, Hansen RM, Findl O. The development of the rod photoresponse from dark-adapted rats. Invest Ophthalmol Vis Sci 1995b; 36: 1038 - 1045.
Futterman S, Stevens-Andrews J. The fatty acid composition of human retinal vitamin A ester and the lipids of human retinal tissue. Invest Ophthalmol Vis Sci 1964; 3: 441 - 444.
Futterman S, Downer JL, Hendrickson A. Effect of essential fatty acid deficiency on the fatty acid composition, morphology, and electroretinographic response of the retina. Invest Ophthalmol Vis Sci 1971; 10: 151 - 156.
Galli C, White H, Paoletti R. Lipid alterations and their reversion in the central nervous system of growing rats deficient in eesential fatty acids. Lipids 1971; 6: 378 - 387.
Gerbi A, Zerouga M, Debray M, et al. ffect of dietary a-linolenic acid on functional characteristic of Na+/ KtATPase isoenzymes in whole brain membranes of weaned rats. Biochim Biophys Acta 1993; 1165: 291 - 298.
Granit R. Components of the retinal action potential in mammals and their relations to the discharge in the optic nerve. J Physiol 1933; 77: 207 - 238.
Greiner R, Moriguchi T, Hutton A, et al. Rats with low levels of brain docosahexaenoic show impaired performance in oflactory-based and spatial learning tasks. Lipids 1999; 34: S239 - S243.
Gurr MI, James AT. Lipid Biochemistry. An Introduction. Chapman and Hall, London, 1980. Holman R Biological activities of and requirements for polyunsaturated fatty acids. Prog Chem Fats Other Lipids 1968; 9: 611 - 680.
Holopigian K, Greenstein VC, Seiple W, et al. Evidence for photoreceptor changes in patients with diabetic retinopathy. Invest Ophthalmol Vis Sci 1997; 38: 2355 - 2365.
Hood DC, Birch DG. A quantitative measure of the electrical activity of human rod photoreceptors using electroretinography. Vis Neurosc 1990a; 5: 379 - 387.
Hood DC, Birch DG. The a-wave of the human ERG and rod receptor function. Invest Ophthalmol Vis Sci 1990b; 31: 2070 - 2081.
Hood DC, Birch DG. Rod phototransduction in retinitis pigmentosa: estimation and interpretation of parameters derived from the rod a-wave. Invest Ophthalmol Vis Sci 1994; 35: 2948 - 2961.
Huster D, Arnold K, Gawrisch K. Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. Biochemistry 1998; 37: 17299 - 308.
Hyman B, Spector A. Choline uptake in cultured human Y79 retinoblastoma cells: effect of polyunsaturated fatty acid compositional modifications. J Neurochem 1982; 38: 650 - 656.
Karwoski CJ, Proenze LM. Light-evoked changes in extracellular potassium concentration in mudpuppy retina. Brain Res 1978; 142: 515 - 530.
Kline RP, Ripps H, Dowling JE. Light induced potassium fluxes in the skate retina. J Neurosci 1985; 464: 225 - 235.
Kraft TW, Schneeweis DM, Schnaft JL. Visual transduction in human rod photoreceptors. J Physiol 1993; 464: 747 - 765.
Kurlack L, Stephenson T. Plausible explanations for effects of long chain polyunstaurated fatty acids on neonates. Arch Dis Child 1999; 80: 148 - 154.
Lamb TD. Transduction in vertebrate photoreceptors: the roles of cyclic GMP and calcium. Trends Neurosci 1986; 9: 224 - 228.
Lamb TD, Pugh EN Jr. A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. J Physiol 1992; 449: 719 - 758.
Lamptey M, Walker B. Learning behaviour and brain lipid composition in rats subjected to essential fatty acid deficiency during gestation, lactation and growth. J Nutr 1978; 108: 358 - 367.
Landis DJ, Dudley PA, Anderson RE. Alteration of disc formation in photoreceptors of rat retina. Science 1973; 182: 1144 - 1146.
Leat WMF, Curtis R, Millichamp NJ, et al. Retinal function in rats and guinea pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. Ann Nutr Metab 1986; 30: 166 - 174.
Liebman PA, Parker KR, Dratz EA. The molecular mechanism of visual excitation and its relation to the structure and composition of the rod outer segment. Ann Rev Physiol 1987; 49: 765 - 791.
Lin DS, Anderson GJ, Connor WE, et al. Effect of dietary n-3 fatty acids upon the phospholipid molecular species of the monkey retina. Invest Ophthalmol Vis Sci 1994; 35: 794 - 803.
Lipton S, Rasmussen H, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus: II. Effects of cyclic nucleotides and prostaglandins. J Gen Physiol 1977; 70: 771 - 791.
Littman BJ, Mitchell DC. A role for phospholipid polyunsaturation in modulating membrane protein function. Lipids 1996; 31: S193 — S197.
Lyubarski A, Pugh E. Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings. J Neurosci 1996; 16: 563 - 571.
Makrides M, Neumann M, Simmer K, et al. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet 1994; 345: 1463 - 1468.
Marmor MF, Zrenner E. Standard for clinical electroretinography (1999 update). Documenta Ophthalmol 1999; 97: 143 - 156.
McMurchie EJ. Dietary lipids and the regulation of membrane fluidity and function In: Aloia, RC, ed. Physiological Regulation of Membrane Fluidity. Alan R. Liss, New York, 1988.
Miller S, Steinberg R. Passive ionic properties of the frog retinal pigment epithelium. J Membr Biol 1977; 36: 337 - 372.
Mitchell DC, Gawrisch K, Litmann BJ, Salem N Jr. Why is docosahexaenoic acid essential for nervous system function? Biochem Soc Trans 1998; 26: 365 - 370.
Naka K, Rushton WA. H. S-potential from luminosity units in the retina of the fish (cyprinidont). J Physiol 1966; 185: 587 - 599.
Nettleton JA. n-3 Fatty acids: comparison of plant and seafood sources in human nutrition. J Am Diet Assoc 1991; 91:331-337.
Neuringer M. The relationship of fatty acid composition to function in the retina and visual system. In: Dobbing J, ed. Lipids, Learning and the Brain: Fats in Infant Formulas, Report of the 103rd Ross Conference on Paediatric Research. Ross Laboratories, Columbus, OH, 1993.
Neuringer M, Connor WE, Lin DS, et al. Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA 1986; 83: 4021 - 4025.
Neuringer M, Jeffrey B, Gibson R. N-3 fatty acid deficiency alters rod phototrandsuction and recovery. [ARVO Abstract]. Invest Ophthalmol Vis Sci 2000; 41: S493.
Nicholls J, Martin A, Wallace B. eds. From Neuron to Brain. Sinauer Associates, Sunderland, MA, 1992. Papahadjopoulos D. Calcium-induced phase changes and fusion in natural and model membranes. In: Poste G, ed. Membrane Fusion. North-Holland, Amsterdam, 1978.
Penn JS, Anderson RE. Effects of light history on the rat retina. Prog Retinal Res 1991; 11: 75 - 98.
Penn RD, Hagins WA. Signal transmission along retinal rods and the origin of the electroretinographic a-wave. Nature 1969; 223: 201 - 205.
Pepperberg DR, Birch DG, Hofmann KP, et al. Recovery kinetics of human rod phototransduction inferred from the two-branched a-wave saturation function. J Opt Soc Am A 1996; 13: 586 - 600.
Quinn PJ. The fluidity of cell membranes and its regulation. Prog Biophysiol Mol Biol 1981; 38: 1 - 104.
Reisbick S, Neuringer M, Connor WE, et al. Postnatal deficiency of omega-3 fatty acids in monkeys: fluid intake and urine concentration. Physiol Behav 1992; 51: 473 - 479.
Reisbick S, Neuringer M, Hasnain R, et al. Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. Physiol Behav 1990; 47: 315 - 323.
Ripps H, Witlovsky P. Neuron-glia interaction in the brain and retina. Prog Retinal Res 1985; 4: 181 - 219.
Rodieck RW. Components of the electroretinogram-a reappraisal. Vision Res 1972; 12: 773 - 780.
Rodieck RW. The primate retina. Compar Primate Biol 1988; 4: 203 - 278.
Rodriguez de Turco EB, Deretic D, Bazan NG, et al. Post-golgi vesicles cotransport docosahexaenoylphospholipids and rhodopsin during frog photoreceptor membrane biogenesis. J Biol Chem 1997; 272(16): 10,491-10,497.
Rotstein NP, Pennacchiotti GL, Sprecher H, et al. Active synthesis of C24:5,n-3 fatty acid in retina. J Biochem 1996; 316: 859 - 864.
Salem Jr., N. Omega-3 fatty acids: molecular and biochemical aspects. In: Spiller GA, Scala J, eds. New Protective Roles for Selected Nutrients. Alan R. Liss, New York, 1989.
Schnapf JL, Baylor DA. How photoreceptors respond to light. Sci Am 1987; 256: 40 - 47.
Sinclair A. The nutritional significance of omega-3 polyunsaturated fatty acids for humans Asean Food 1993; J8: 3 - 13.
Sinclair AJ. Long chain polyunsaturated fatty acids in the mammalian brain. Proc Nutr Soc 1975; 34: 287 - 291.
Steinberg RH, Linsenmeier RA, Griff ER. Retinal pigment epithelial cell contributions to the electroretingram and electrooculogram. Prog Retinal Res 1985; 4: 33 - 66.
Steinberg RH, Schmidt R, Brown K. Intracellular responses to light from the cat retinal pigment epithelium: origin of the electroretinogram c-wave. Nature 1970; 227: 728 - 730.
Stryer L. Biochemistry. WH Freeman, New York, 1981.
Stryer L. The cyclic GMP cascade of vision. Ann Rev Neurosci 1986; 9: 87 - 119.
Tinoco J, Williams M, Hincenbergs I, et al. Evidence for nonessentiality of linolenic acid in the diet of the rat. J Nutr 1971; 101: 937 - 946.
Treen M, Uauy RD, Jameson DM, et al. Effect of docosahexaenoic acid on membrane fluidity and function in intact cultured Y-79 retinoblastoma cells. Arch Biochem Biophysiol 1992; 294: 564 - 570.
Uauy R, Hoffman DR. Essential fatty acid requirements for normal eye and brain development. Semin Perinatol 1991; 15: 449 - 455.
Uauy RD, Birch EE, Birch DG, et al. Significance of w3 fatty acids for retinal and brain development of preterm and term infants. World Rev Nutr Diet 1994; 75: 52 - 62.
Umezawa M, Kogishi K, Tojo H, et al. High linoleate and high alpha linolenate diets affect learning ability and natural behaviour in SAMRI mice. J Nutr 1999; 129: 431 - 437.
Vingrys AJ, Weisinger HS, Sinclair AJ. The effect of age and n-3 PUFA level on the ERG in the guinea pig. In: Huang Y. Sinclair A eds., Lipids and Infant Nutrition. AOCS, Champaign, IL, 1998.
Voss A, Reinhart S, Sankarappa S, et al. Metabolism of 22:5n-3 to 22:6n-3 in rat liver is independent of 4-desaturase. J Biol Chem 1991; 166: 1995 - 2000.
Wainwright P. Do essential fatty acids play a role in brain and behavioural development? Biol Behav Rev 1992; 16: 193 - 205.
Wang N, Anderson RE. Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. Biochemistry 1993; 32:13, 703-13, 709.
Ward G. Wainwright P. The contribution of animal models to understanding the role of fats in infant nutrition. In: Huang Y, Sinclair A, eds. Lipids in Nutrition. AOCS, Champaign, IL, 1998.
Ward G, Woods J, Reyzer M, et al. Artificial rearing of infant rats on milk formula deficient in n-3 essential fatty acids: a rapid method fo the production of experimental n-3 deficiency. Lipids 1996; 31: 71 - 78.
Watanabe I, Aonuma H, Kaneko S, et al. Effect of high linoleate and high a-linoleate diets on size distribution of phagosomes in retinal pigment epithelium. In: Yasugi T, Nakamura H, Soma M, eds. Advances in Polyunsaturated Fatty Acid Research. Elsevier, Amsterdam, 1993.
Weisinger HS. The effect of docosahexanaenoic acid on the electroretinogram of the guinea pig.MSc dissertation, University of Melbourne, Melbourne, 1995.
Weisinger HS, Sinclair AJ, Vingrys AJ. Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. Ann Nutr Metab 1996; 40: 91 - 98.
Weisinger HS, Vingrys AJ, Sinclair AJ. Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. Lipids 1995; 30: 471 - 473.
Weisinger HS, Vingrys AJ, Sinclair AJ. The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. Lipids 1996a; 31 (1): 65 - 70.
Weisinger HS, Vingrys AJ, Sinclair AJ. Electrodiagnostic methods in vision. Parts 1-3: Clinical experimental optometry 1996b; 79:50-61; 97-105; 131 - 143.
Weisinger HS, Vingrys AJ, Sinclair AJ. Effect of diet on the rate of depletion of n-3 fatty acids in the retina of the guinea pig. J Lipid Res 1998; 39: 1274 - 1279.
Weisinger HS, Vingrys AJ, Bui BV, et al. Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. Invest Ophthalmol Vis Sci 1999; 40: 327 - 338.
Wheeler TG, Benolken RM, Anderson RE. Visual membranes: specificity of fatty acid precursors for the electrical response to illumination. Science 1975; 188: 1312 - 1314.
Witkovsky P, Dudek FE, Ripps H. Slow PIII component of the carp electroretinogram. J Gen Physiol 1975; 65: 119 - 134.
Yau KW. Phototransduction in retinal rods and cones. Invest Ophthalmol Vis Sci 1994; 35: 9 - 32.
Yoshida S, Yasuda A, Kawasato H, et al. Ultrastructural study of hippocampus synapse in perilla and safflower oil fed rats. In: Yasugi T, Nakamura H, Soma M, eds. Advances in Polyunsaturated Fatty Acid Research. Elsevier, Amsterdam, 1993.
Young R. The renewal of photoreceptor cell outer segments. J Cell Biol 1967; 42: 392 - 403.
Young R, Bok D. Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol 1969; 42: 392 - 403.
Youyou A, Durand G, Pascal G, et al. Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. J Neurochem 1986; 46: 224 - 228.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Vingrys, A.J., Armitage, J.A., Weisinger, H.S., Bui, B.V., Sinclair, A.J., Weisinger, R.S. (2001). The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function. In: Mostofsky, D.I., Yehuda, S., Salem, N. (eds) Fatty Acids. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-119-0_12
Download citation
DOI: https://doi.org/10.1007/978-1-59259-119-0_12
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-265-0
Online ISBN: 978-1-59259-119-0
eBook Packages: Springer Book Archive