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Retroviral Immunology pp 109–123Cite as

HIV Gene Products as Manipulators of the Immune System

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Part of the book series: Infectious Disease ((ID))

Abstract

The spread of human immunodeficiency virus (HIV) in the body depends on its fitness to replicate and on its ability to escape immune defenses. The viral proteins Nef, Tat, and Env, best known for their direct effects on the viral life cycle, are also crucially engaged in manipulating various components of the immune system, both to prepare the ground for viral propagation and to facilitate immune evasion. This chapter reviews these lesser known functions of the three HIV gene products, which govern fascinating interactions between the virus and its host.

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Authors
  1. Aram Mangasarian
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  2. Didier Trono
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Editor information

Editors and Affiliations

  1. Hospital de Beaumont, Lausanne, Switzerland

    Giuseppe Pantaleo MD

  2. Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Bruce D. Walker MD

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© 2001 Humana Press Inc., Totowa, NJ

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Mangasarian, A., Trono, D. (2001). HIV Gene Products as Manipulators of the Immune System. In: Pantaleo, G., Walker, B.D. (eds) Retroviral Immunology. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-110-7_5

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  • DOI: https://doi.org/10.1007/978-1-59259-110-7_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-128-8

  • Online ISBN: 978-1-59259-110-7

  • eBook Packages: Springer Book Archive

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