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Role of Chemokines and Their Receptors in the Pathogenesis of HIV Infection

  • Frederick S. Lee
  • Gabriele Kuschert
  • Otto O. Yang
  • Andrew D. Luster
Chapter
Part of the Infectious Disease book series (ID)

Abstract

The chemokines comprise a rapidly expanding group of chemotactic cytokines now known to play a critical role in regulating leukocyte trafficking during development and in homeostasis, inflammation, and infection. In the brief period since the original description of platelet factor 4 (PF4) (1) and interferon-inducible protein of 10 kDa (IP-10) (2) this family has grown to more than 50 members. Numerous studies now link chemokines to the pathogenesis of a wide range of inflammatory processes including asthma, atherosclerosis, pneumonia, meningitis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, and sarcoidosis, among others (3). Many also play roles in angiogenesis, hematopoiesis, and fetal development.

Keywords

Human Immunodeficiency Virus Infection Chemokine Receptor Acquire Immune Deficiency Syndrome Simian Immunodeficiency Virus Chemokine Receptor CXCR4 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Frederick S. Lee
  • Gabriele Kuschert
  • Otto O. Yang
  • Andrew D. Luster

There are no affiliations available

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