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Retroviral Immunology pp 297–316Cite as

Polymorphism in HLA and Other Elements of the Class I and II Response Pathways

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Abstract

Vertebrates have evolved a variety of intracellular, cell-surface, and extracellular systems for distinguishing their own biological products from components of unfamiliar intruders such as viruses and other microorganisms. Prominent among the systems for initiating an immune response to these foreign microbes is the machinery of the major histocompatibility complex (MHC), utilized by certain antigen-presenting cells (APCs) including dendritic cells, macrophages, and B cells, to initiate immune surveillance of peptide fragments from both externally introduced and internally derived proteins. The huge array of molecular variants encoded in the MHC, or human leukocyte antigen (HLA) system, mediate events along several major immunologic pathways critical to the control of infection. This chapter summarizes information about HLA and closely related genes, how polymorphisms in these genes influence the course and the control of human immunodeficiency virus type 1 (HIV-1) infection in human populations, and how current knowledge of the major HLA-mediated response mechanisms might inform efforts to reconstitute virus-impaired host immunity.

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Authors
  1. Richard A. Kaslow
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  2. R. Pat Bucy
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Editors and Affiliations

  1. Hospital de Beaumont, Lausanne, Switzerland

    Giuseppe Pantaleo MD

  2. Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Bruce D. Walker MD

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Kaslow, R.A., Bucy, R.P. (2001). Polymorphism in HLA and Other Elements of the Class I and II Response Pathways. In: Pantaleo, G., Walker, B.D. (eds) Retroviral Immunology. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-110-7_13

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  • DOI: https://doi.org/10.1007/978-1-59259-110-7_13

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