Intrahost Selective Pressure and HIV-1 Heterogeneity During Progression to AIDS

  • Vladimir V. Lukashov
  • Jaap Goudsmit
Part of the Infectious Disease book series (ID)


One of the most striking characteristics of human immunodeficiency virus type 1 (HIV-1) is the immense genetic variation of this virus. Within a single individual, HIV-1 population exists at any given time point as a swarm of mutant viruses, in which all viruses are genetically related yet virtually every virus is unique (intrahost heterogeneity) and is changing over time on almost a daily basis (intrahost evolution). Moreover, infected individuals within a human population harbour distinct viruses (interhost or population-wide heterogeneity). The majority of HIV-1 strains could be grouped into genetic subtypes A–J of HIV-1 group M, based on phylogenetic analysis of their sequences (1–9). Many viruses have been shown to have mosaic genomes, in which different genes or gene regions are related to distinct HIV-1 subtypes (10,11). A few dozens of HIV-1 strains described so far belong to more distant HIV-1 groups O and N (12).


Human Immunodeficiency Virus Type Acquire Immune Deficiency Syndrome Virus Population Acquire Immune Deficiency Syndrome Progression Acquire Immune Deficiency Syndrome Diagnosis 
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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Vladimir V. Lukashov
  • Jaap Goudsmit

There are no affiliations available

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