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Mechanisms of Neuronal Apoptosis and Excitotoxicity

  • Chapter
Book cover Pathogenesis of Neurodegenerative Disorders

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Apoptosis is a form of cell death that is mediated by specific biochemical cascades involving mitochondrial changes and activation of proteases called caspases. Apoptosis provides a mechanism for cells to die without adversely affecting their neighbors (Fig. 1). This contrasts with a nonregulated form of cell death called necrosis, in which cellular organelles swell and the plasma membrane becomes permeable, resulting in release of cellular contents and massive death of groups of cells throughout a tissue. Aberrant regulation of apoptosis may be the central abnormality in many different diseases, most prominent of which are cancers wherein cells become resistant to apoptosis. Therefore, a major effort in the field of cancer research is to identify the molecular alterations responsible for such cell immortalization (Wyllie, 1997).

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Authors
  1. Mark P. Mattson
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Editors and Affiliations

  1. Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD, USA

    Mark P. Mattson

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© 2001 Springer Science+Business Media New York

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Mattson, M.P. (2001). Mechanisms of Neuronal Apoptosis and Excitotoxicity. In: Mattson, M.P. (eds) Pathogenesis of Neurodegenerative Disorders. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-106-0_1

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  • DOI: https://doi.org/10.1007/978-1-59259-106-0_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-215-5

  • Online ISBN: 978-1-59259-106-0

  • eBook Packages: Springer Book Archive

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