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The Blood-Brain Barrier in the Aging Brain

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Book cover Neuroglia in the Aging Brain

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Homeostasis of the extracellular microenvironment in the neural tissue of the brain as well as its protection against neurotoxic compounds and variations in the composition of the blood are important for normal function of the neurons. It is warranted by a structure formed between blood and brain which is therefore called the blood-brain barrier (BBB). This barrier has been postulated in earlier decades by experiments using dyes which directly visualized both the protection of the brain if injected into the vasculature, and free access of the brain if injected into the cerebrospinal fluid. Since in the first experiment some areas of the brain around the ventricle were stained and in the second experiment the identical areas were not, the barrier necessarily had to be separated into a BBB and a blood-cerebrospinal fluid barrier.

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Authors
  1. Gesa Rascher
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  2. Hartwig Wolburg
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Editors and Affiliations

  1. UCLA Mental Retardation Research Center, Los Angeles, CA, USA

    Jean S. de Vellis PhD

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Rascher, G., Wolburg, H. (2002). The Blood-Brain Barrier in the Aging Brain. In: de Vellis, J.S. (eds) Neuroglia in the Aging Brain. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-105-3_17

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  • DOI: https://doi.org/10.1007/978-1-59259-105-3_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-088-5

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