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Principles of Molecular Regulation pp 115–132Cite as

gp130-Related Cytokines

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Abstract

Cytokines are secreted multifunctional proteins, exerting local autocrine and paracrine, as well as sys- temic endocrine actions. Although originally thought to be derived from hematopoietic and immune cells, these molecules are secreted by a variety of different cell types and affect multiple target cells. Cytokine actions are characterized by biological pleiotropy and redundancy. Most cytokines affect different biological target cells and act in a cell type specific fashion. Cytokine families often exhibit similar or overlapping functions in a specific target tissue, as they use common receptor subunits and signaling cascades. Different factors, for example, interleukins (ILs), tumor necrosis factors, interferons (IFNs), colony-stimulating factors, chemokines, and others, have been categorized as cytokines, and the definition criteria are some what arbitrary. Cytokines act through specific receptors and use common signaling pathways.

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Authors
  1. Christoph J. Auernhammer
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  2. Shlomo Melmed
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Editors and Affiliations

  1. Oregon Regional Primate Research Center, Beaverton, and Oregon Health Sciences University, Portland, OR, USA

    P. Michael Conn PhD

  2. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA

    Anthony R. Means PhD

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Auernhammer, C.J., Melmed, S. (2000). gp130-Related Cytokines. In: Conn, P.M., Means, A.R. (eds) Principles of Molecular Regulation. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-032-2_7

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