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Leiomyoma and Leiomyosarcoma

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Infectious Causes of Cancer

Part of the book series: Infectious Disease ((ID))

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Abstract

A relatively recent scientific finding over the past decade has been the chronicle of epidemiologic and virologic investigations that have documented the increased frequency of smooth muscle cell tumors in immunocompromised persons, and the unexpected association of these tumors with Epstein-Barr virus (EBV) infection of smooth muscle cells. In 1965, Nobel laureate Sir MacFarlane Burnet emphasized the critical role of immunosurveillance in limiting malignant transformation and development of cancer (1). The acquired immunodeficiency syndrome (AIDS) epidemic, and also the development of powerful immunosuppressive drugs that have made organ transplantation possible, have validated the important role of tumor immunosurveillance. Immunocompromised individuals, whether the underlying cause is congenital, iatrogenic, or secondary to infection, have an approx 10-100-fold higher incidence of malignancies than immunocompetent individuals, with the frequent occurrence of unusual tumor types (2).

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  1. Hal B. Jenson
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  1. Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Room 8012, MSC 7248, 20852, Rockville, MD, USA

    James J. Goedert MD (Chief) (Chief)

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Jenson, H.B. (2000). Leiomyoma and Leiomyosarcoma. In: Goedert, J.J. (eds) Infectious Causes of Cancer. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-024-7_9

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  • DOI: https://doi.org/10.1007/978-1-59259-024-7_9

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