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Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action

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Cerebral Signal Transduction

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

The dopamine transporter (DAT) is the primary mechanism by which extracellular dopamine is cleared from the synaptic space. As such, it performs a key role in terminating synaptic transmission and in regulating the concentration of dopamine available for binding to presynaptic and postsynaptic dopamine receptors. DAT is also a major site of action for psychostimulants such as cocaine and amphetamine, and is believed to be involved with the reinforcing properties of these drugs. It has recently been found that activation of protein kinase C leads to reductions in dopamine transport and concomitant phosphorylation of DATs, suggesting that the protein undergoes functional regulation by phosphorylation. Other kinases may function similarly, providing neurons with a mechanism for fine temporal and spatial control of extracellular dopamine concentrations and subsequent neural activity. Therefore, phosphorylation of DAT has the potential to profoundly influence dopaminergic neurophysiology and may be related to mechanisms of cocaine abuse.

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  1. Roxanne A. Vaughan
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  1. College of Medicine, University of Illinois, Peoria, IL, USA

    Maarten E. A. Reith

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Vaughan, R.A. (2000). Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action. In: Reith, M.E.A. (eds) Cerebral Signal Transduction. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-019-3_14

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  • DOI: https://doi.org/10.1007/978-1-59259-019-3_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9615-4

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