D1927 and D2163

Novel Mercaptoamide Inhibitors of Matrix Metalloproteinases
  • A. D. Baxter
  • J. B. Bird
  • R. Bannister
  • R. Bhogal
  • D. T. Manallack
  • R. W. Watson
  • D. A. Owen
  • J. Montana
  • J. Henshilwood
  • R. C. Jackson
Part of the Cancer Drug Discovery and Development book series (CDD&D)


This chapter aims to provide a historical perspective of the Chiroscience matrix metalloproteinase inhibitor (MMPI) program, including the medicinal chemistry strategy which culminated in the clinical candidates D 1927 and D2163. We shall focus on the design of substrate-based inhibitors utilizing a novel zinc-binding group, and the discovery of novel MMPIs that display selectivity for the matrix metalloproteinases (MMPs) over the related metalloproteinase enzymes that mediate cellular shedding events will be reviewed.


Hydroxamic Acid Matrix Metalloproteinase Inhibitor Stereogenic Center Oral Activity Broad Spectrum Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • A. D. Baxter
  • J. B. Bird
  • R. Bannister
  • R. Bhogal
  • D. T. Manallack
  • R. W. Watson
  • D. A. Owen
  • J. Montana
  • J. Henshilwood
  • R. C. Jackson

There are no affiliations available

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