Because of widespread treatment of systemic hypertension, true refractory hypertension is somewhat unusual in the current management of hypertensive disorders. A majority of patients with uncomplicated primary hypertension respond to one or two drugs. Hypertension is considered refractory if the blood pressure (BP) cannot be reduced below 140/90 mmHg in patients who are compliant with an appropriate triple-drug regimen that includes a diuretic, with all the components prescribed in near maximal or tolerated doses. For patients with isolated systolic hypertension, refractoriness is defined as a failure of an adequate triple-drug regimen to reduce systolic blood pressure below 160 mmHg.
KeywordsObstructive Sleep Apnea Resistant Hypertension Renovascular Hypertension Target Organ Damage White Coat Hypertension
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