Angiotensin II Receptor Blockers
The angiotensin II (Ang II) receptor antagonists are the most selective blockers of the renin-angiotensin system (RAS) currently available. The efficacy of these drugs is similar to that of the other major antihypertensive drug classes, but they appear to exhibit fewer side effects. Angiotensin receptor blockers (ARBs) selectively block the angiotensin AT1 receptors, leaving AT2 receptors exposed to increased circulating concentrations of Ang II. It is not yet known whether the AT2 receptor is expressed or mediates meaningful hemodynamic or vascular effects in clinical hypertension. ARB and angiotensin-converting enzyme (ACE) inhibitors differ in their interactions with the RAS, bradykinin, and other neurohormonal mediators; the two drug classes have similar hemodynamic effects, but it is not yet known whether they might have differential impacts on clinical outcomes. Although ARBs are still relatively new, several rigorous clinical trials with morbidity and mortality end points are already in progress.
KeywordsBlood Pressure Effect Rigorous Clinical Trial Major Antihypertensive Drug Class Inhibitor Clinical Trial Arterial Wall Hypertrophy
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