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Early Diagnosis of Alzheimer’s Disease

An Introduction

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Book cover Early Diagnosis of Alzheimer’s Disease

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Alzheimer’s disease (AD) is poised to become the scourge of the next century, bringing with it enormous social and personal costs. Depending on the methods of assessment used, estimates of the prevalence of dementia due to AD in Americans 65 and older range from 6% to 10% (1–3). The prevalence of the disease doubles every 5 years after the age of 60 (4–6). For the population 85 and older, estimates of the prevalence have been as high as 30–47% (1–3). As many as 4 million Americans may suffer from a clinical dementia of the Alzheimer’s type, with an annual cost of approximately $100 billion (7). Based on current rates, and in the absence of effective prevention, it is estimated that in 50 years, there will be as many as 14 million cases of clinically diagnosed Alzheimer’s disease in the United States alone. While AD is a major public health problem, it also has a very private face that causes tremendous suffering to families. For the elderly, it one of the most dreaded afflictions that threatens to rob them of their independence and dignity at the end of life.

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References

  1. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ. Prevalence of Alzheimer’s disease in a community population of older persons: higher than previously reported. JAMA 1989;262:2551–2556.

    Article  PubMed  CAS  Google Scholar 

  2. Ritchie K, Kildea D. Is senile dementia “age related” or “aging related”?: evidence from a meta-analysis of dementia prevalence in the oldest old. Lancet 1995; 346:931–934.

    Article  PubMed  CAS  Google Scholar 

  3. Small GW, Rabins PV, Barry PP, Buckholtz NS, DeKosky ST, Ferris SH, Finkel SI, Gwyther LP, Khachaturian ZS, Lebowitz BD, McRae TD, Morris JC, Oakley F, Schneider LS, Streim JE, Sunderland T, Teri LA, Tune LE. Diagnosis and treatment of Alzheimer disease and related disorders. JAMA 1997;278:1363–1371.

    Article  PubMed  CAS  Google Scholar 

  4. Jorm AF. The Epidemiology of Alzheimer’s Disease and Related Disorders. London: Chapman & Hall, 1990.

    Google Scholar 

  5. Bachman DL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, White LR, D’Agostino RB. Incidence of dementia and probable Alzheimer’s disease in a general population: the Framingham Study. Neurology 1993;42:515–519.

    Article  Google Scholar 

  6. Paykel ES, Brayne C, Huppert FA, Gill C, Barkley C, Gelhaar E, Beardsall L, Girling DM, Pollitt P, O’Connor D. Incidence of dementia in a population older than 75 years in the United Kingdom. Arch. Gen. Psychiatry 1994;51:325–332.

    Article  PubMed  CAS  Google Scholar 

  7. Schumock GT. Economic considerations in the treatment and management of Alzheimer’s disease. Am. J. Health Syst. Pharm. 1998;55(Suppl. 2):S17-S21.

    PubMed  Google Scholar 

  8. Breitner JCS. Clinical genetics and genetic counseling in Alzheimer’s disease. Ann. Intern. Med. 1991;115:601–606.

    PubMed  CAS  Google Scholar 

  9. De Souza EB, Whitehouse PJ, Kuhar M J, Price DL, Vale WW. Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer’s disease. Nature 1986;319:593–594.

    Article  PubMed  Google Scholar 

  10. Cohen BM, Zubenko GS, Babb SM. Abnormal platelet membrane composition in Alzheimer’s-type dementia. Life Sei. 1987;40:2445–2451.

    Article  CAS  Google Scholar 

  11. Tanzi RE, Gusella JF, Watkins PC, Bruns GAP, St. George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL. Amyloid ß protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987; 235:880–884.

    Article  PubMed  CAS  Google Scholar 

  12. Zubenko GS, Teply I. Longitudinal study of platelet membrane fluidity in Alzheimer’s disease. Biol. Psychiatry 1988;24:918–924.

    Article  PubMed  CAS  Google Scholar 

  13. Johnson KA, Holman L, Rosen J, Nagel S, English RJ, Growdon JH. Iofetamine I 123 single proton emission computed tomography is accurate in the diagnosis of Alzheimer’s disease. Arch. Intern. Med. 1990;150:752–756.

    Article  PubMed  CAS  Google Scholar 

  14. Matsubara E, Hirai S, Amari M, et al. Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia. Ann. Neurol. 1990;28:561–567.

    Article  PubMed  CAS  Google Scholar 

  15. de la Monte SM, Volicer L, Hauser SL, Wands JR. Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer’s disease. Ann. Neurol. 1992;32:733–742.

    Article  PubMed  Google Scholar 

  16. Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A. The scintigraphic appearance of Alzheimer’s disease: a prospective study using technetium-99m-HMPAO SPECT. J. Nucl. Med. 1992;33:181–185.

    PubMed  CAS  Google Scholar 

  17. Jack CR Jr, Petersen RC, O’Brien PC, Tangalos EG. MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 1992;42:183–188.

    Article  PubMed  Google Scholar 

  18. Jobst KA, Smith AD, Barker CS, Wear A, King EM, Smith A, Anslow PA, Molyneux AJ, Shepstone BJ, Soper N, et al. Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer’s disease. J. Neurol.Neurosurg. Psychiatry 1992;55:190–194.

    Article  PubMed  CAS  Google Scholar 

  19. Jobst KA, Smith AD, Szatmari M, Molyneux A, Esiri ME, King E, Smith A, Jaskowski A, McDonald B, Wald N. Detection in life of confirmed Alzheimer’s disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet 1992;340:1179–1183.

    Article  PubMed  CAS  Google Scholar 

  20. Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL. Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer’s disease. Proc. Natl Acad. Sei. U.S.A. 1993;90:8209–8213.

    Article  CAS  Google Scholar 

  21. Johnson K, Kijewski MF, Becker A, Garda B, Satlin A, Holman BL. Quantitative brain SPECT in Alzheimer’s disease and normal aging. J. Nucl. Med. 1993; 34:2044–2048.

    PubMed  CAS  Google Scholar 

  22. Killiany RJ, Moss MB, Albert MS, Sandor T, Tieman J, Jolesz F. Temporal lobe regions on magnetic resonance imagiing identify patients with early Alzheimer’s disease. Arch. Neurol. 1993;50:949–954.

    Article  PubMed  CAS  Google Scholar 

  23. Masur DM, Śliwiński M, Lipton RB, Blau AD, Crystal HA. Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology 1994;44:1427–1432.

    Article  PubMed  CAS  Google Scholar 

  24. Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG, et al. Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer’s disease. Ann. Neurol. 1994;36:903–911.

    Article  PubMed  CAS  Google Scholar 

  25. Parker WD Jr, Mahr NJ, Filley CM, Parks JK, Hughes D, Young DA, Cullum CM. Reduced platelet cytochrome c oxidase activity in Alzheimer’s disease. Neurology 1994;44:1086–1090.

    Article  PubMed  Google Scholar 

  26. Parker WD Jr, Parks J, Filley CM, Kleinschmidt-DeMasters BK. Electron transport chain defects in Alzheimer’s disease brain. Neurology 1994;44:1090–1096.

    Article  PubMed  Google Scholar 

  27. Petersen RC, Smith GE, Ivnik RJ, Kokmen E, Tangalos EG. Memory function in very early Alzheimer’s disease. Neurology 1994;44:867–872.

    Article  PubMed  CAS  Google Scholar 

  28. Scinto LF, Daffner KR, Dressier D, Ransil BJ, Rentz D, Weintraub S, Mesulam M, Potter H. A potential noninvasive neurobiological test for Alzheimer’s disease. Science 1994;226:1051–1054.

    Article  Google Scholar 

  29. Simonian NA, Hyman BT. Functional alterations in Alzheimer’s disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. /. Neuropathol. Exp. Neurol. 1994;53:508–512.

    Article  CAS  Google Scholar 

  30. Arai H, Terajima M, Miura M, Higuchi S, Muramatsu T, Machida N, Seiki H, Takase S, Clark CM, Lee VM-Y, Trojanowski JQ, Sasaki H. Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer’s disease. Ann. Neurol. 1995; 38:649–652.

    Article  PubMed  CAS  Google Scholar 

  31. DeCarli C, Murphy DGM, Mcintosh AR, Teichberg D, Schapiro MB, Horwitz B. Discriminant analysis of MRI measures as a method to determine the presence of dementia of the Alzheimer type. Psychiatry Res. 1995;57:119–130.

    Article  Google Scholar 

  32. Jacobs DM, Sano M, Dooneief G, Marder K, Bell KL, Stern Y. Neuropsychological detection and characterization of preclinical Alzheimer’s disease. Neurology 1995;45:957–962.

    Article  PubMed  CAS  Google Scholar 

  33. Laakso MP, Soininen H, Partanen K, Helkala EL, Hartikainen P, Vainio P, Hallikainen M, Hanninen T, Riekkinen PJ. Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer’s disease: correlation with memory functions. J. Neural Transm. Dis. Dement Sect. 1995;9:73–86.

    Article  CAS  Google Scholar 

  34. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KAB, Weber JL, Bird TD, Schellenberg G.D. A familial Alzheimer’s disease locus on chromosome 1. Science 1995;269:970–973.

    Article  PubMed  CAS  Google Scholar 

  35. Licastro F, Morini MC, Polazzi E, Davis LJ. Increased serum alpha 1-antichy-motrypsin in patients with probable AD: an acute phase reactant without the peripheral acute phase response. J. Neuroimmunol. 1995;57:71–75.

    Article  CAS  Google Scholar 

  36. Linn RT, Wolf PA, Bachman DL, Knoefel JE, Cobb JL, Belanger AJ, Kaplan EF, D’Agostino RB. The “preclinical phase” of probably Alzheimer’s disease. Arch. Neurol. 1995;52:485–490.

    Article  PubMed  CAS  Google Scholar 

  37. Motter R, Vigo-Pelfrey C, Kholodenko D, Barbour R, Johnson-Wood K, Galasko D, Chang L, Miller B, Clark C, Green R, Olsen D, Soutwick P, Wolfert R, Munroe R, Lieberburg I, Seubert P, Schenck, D. Reduction of ß-amyloid peptide in the cerebrospinal fluid of patients with Alzheimer’s disease. Ann. Neurol. 1995; 38:643–648.

    Article  PubMed  CAS  Google Scholar 

  38. Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, Kokmen E, Waring SC, Kurland LT. Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. JAMA 1995;273:1274–1278.

    Article  PubMed  CAS  Google Scholar 

  39. Roses AD. Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer’s disease. Ann. Neurol. 1995;38:6–14.

    Article  PubMed  CAS  Google Scholar 

  40. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St. George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 1995;375:754–760.

    Article  PubMed  CAS  Google Scholar 

  41. Small GS, Mazziotta JC, Collins MT, Baxter LR, Phelps ME, Mandelkern MA, Kaplan A, LaRue A, Adamson CF, Chang L, Guze BH, Corder EH, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer’s disease. JAMA 1995;273:942–947.

    Article  PubMed  CAS  Google Scholar 

  42. Van de Voorde A, Vanmechelen E, Vandemeeren M, et al. Detection of tau in cerebrospinal fluid. In Iqbal K, Mortimer JA, Winblad B, Wiśniewski HM, editors. Research Advances in Alzheimer’s Disease and Related Disorders. Chichester: John Wiley & Sons Ltd., 1995:189–195.

    Google Scholar 

  43. Vigo-Pelfrey C, Seubert P, Blomquist C, et al. Tau in cerebrospinal fluid: an ante-mortem marker for Alzheimer’s disease? In Iqbal K, Mortimer JA, Winblad B, Wiśniewski HM, editors. Research Advances in Alzheimer’s Disease and Related Disorders. Chichester: John Wiley & Sons Ltd., 1995:197–205.

    Google Scholar 

  44. Eckert A, Forstl H, Zerfass R, Hartmann H, Muller WE. Lymphocytes and neurophils as peripheral models to study the effects of beta-amyloid on cellular signalling in Alzheimer’s disease. Life Sei. 1996;59:5–6.

    Article  Google Scholar 

  45. Fox NC, Warrington EK, Freeborough PA, Hartikainen P, Kennedy AM, Stevens JM, Rossor MN. Presymptomatic hippocampal atrophy in Alzheimer’s disease: a longitudinal MRI study. Brain 1996;119:2001–2007.

    Article  PubMed  Google Scholar 

  46. Gibson GE, Zhang H, Toral-Barza L, Szolosi S, Tofel-Grehl B. Calcium stores in cultured fibroblasts and their changes with Alzheimer’s disease. Biochem. Biophys.Acta 1996;1316:71–77.

    Article  PubMed  Google Scholar 

  47. Kennard ML, Feldman H, Yamada T, Jeffries WA. Serum levels of the iron binding protein p97 are elevated in Alzheimer’s disease. Nat. Med. 1996;2: 1230–1235.

    Article  PubMed  CAS  Google Scholar 

  48. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D. Preclinical evidence of Alzheimer’s disease in persons homozygous for the e4 allele for apolipoprotein E. N. Engl. J. Med. 1996;334:752–758.

    Article  CAS  Google Scholar 

  49. Saunders AM, Hulette C, Welsh-Bohmer KA, Schmechel DE, Crain B, Burke JR, Alberts MJ, Strittmatter WJ, Breitner JCS, Rosenberg C, Scott SV, Gaskell PC Jr, Pericak-Vance MA, Roses AD. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer’s disease. Lancet 1996; 348:90–93.

    Article  PubMed  CAS  Google Scholar 

  50. Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, Dunn E, St. George-Hyslop PH. Prediction of probable Alzheimer’s disease in memory-impaired patients: a prospective longitudinal study. Neurology 1996;46:661–665.

    Article  PubMed  CAS  Google Scholar 

  51. de la Monte SM, Ghanbari K, Frey WH, Beheshti I, Averback P, Hauser SL, Ghanbari HA, Wands JR. Characterization of the AD7C-NTP cDNA expression in Alzheimer’s disease and measurement of a 41-kD protein in cerebrospinal fluid. J. Clin. Invest. 1997;100:3093–3104.

    Article  PubMed  CAS  Google Scholar 

  52. Growdon JH, Graefe K, Tennis M, Hayden D, Schoenfeld D, Wray SH. Pupil dilation to tropicamide is not specific for Alzheimer’s disease. Arch. Neurol. 1997; 54:841–844.

    Article  PubMed  CAS  Google Scholar 

  53. Higuchi S, Matsushita S, Hasegawa Y, Muramatsu T, Arai H, Hayashida M. Apolipoprotein E e4 allele and pupillary response to tropicamide. Am. J. Psychiatry 1997;154:694–696.

    PubMed  CAS  Google Scholar 

  54. Jack CR Jr, Petersen RC, Xu YC, Waring SC, O’Brien PC, Tangalos EG, Smith GE, Ivnik RJ, Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease. Neurology 1997;49:786–794.

    Article  PubMed  Google Scholar 

  55. Kaiman J, Kanka A, Magloczky E, Szoke A, Jardanhazy T, Janka Z. Increased mydriatic response to tropicamide is a sign of cholinergic hypersensitivity but not specific to late-onset sporadic type of Alzheimer’s disease. Biol. Psychiatry 1997; 41:909–911.

    Article  Google Scholar 

  56. Kaye JA, Swihart T, Howieson D, Dame A, Moore MM, Karnos T, Camicioli R, Ball M, Oken B, Sexton G. Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology 1997;48: 1297–1304.

    Article  PubMed  CAS  Google Scholar 

  57. Riemenschneider M, Buch K, Schmolke M, Kurz A, Guder WG. Diagnosis of Alzheimer’s disease with cerebrospinal fluid tau protein and aspartate aminotransferase. Lancet 1997;350:784.

    Article  PubMed  CAS  Google Scholar 

  58. Roses AD. Genetic testing for Alzheimer’s disease: practical and ethical issues. Arch. Neurol. 1997;54:1226–1229.

    Article  PubMed  CAS  Google Scholar 

  59. Kaneyuki H, Mitsuno S, Nishida T, Yamada M. Enhanced miotic response to topical dilute pilocarpine in patients with Alzheimer’s disease. Neurology 1998;50: 802–804.

    Article  PubMed  CAS  Google Scholar 

  60. Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M. Longitudinal study of cerebrospinal fluid levels of tau, A ß 1–40, and A ß 1–42(43) in Alzheimer’s disease: a study in Japan. Ann. Neurol. 1998;44:17–26.

    Article  PubMed  CAS  Google Scholar 

  61. Growdon JH. To tap or not to tap: cerebrospinal fluid biomarkers in Alzheimer’s disease (editorial; comment). Ann. Neurol. 1998;44:6–7.

    Article  PubMed  CAS  Google Scholar 

  62. Hulstaert F, Blennow K, Ivanoiu A, Schoonderwaldt HC, Riemenschneider M, De Deyn PP, Bancher C, Cras P, Wiltfang J, Mehta PD, Iqbal K, Pottel H, Vanmechelen E, Vanderstichele H. Improved discrimination of AD patients using beta-amyloid (1–42) and tau levels in CSF. Neurology 1999;52:1555–1562.

    Article  PubMed  CAS  Google Scholar 

  63. Larson EB, Reitler BV, Sumi SM, Canfield CG, Chann NM. Diagnostic tests in the evaluation of dementia: a prospective study of 200 elderly outpatients. Arch. Intern. Med. 1986;146:1917–1922.

    Article  PubMed  CAS  Google Scholar 

  64. Clarfield AM. The reversible dementias: do they reverse? Ann. Intern. Med. 1988; 109:476–486.

    PubMed  CAS  Google Scholar 

  65. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of the department of health and human services task force on Alzheimer’s disease. Neurology 1984;34:939–944.

    Article  PubMed  CAS  Google Scholar 

  66. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 1989;3:1159–1165.

    Google Scholar 

  67. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association, 1994.

    Google Scholar 

  68. Khachaturian Z. Diagnosis of Alzheimer’s disease. Arch. Neurol. 1985;42: 1097–1105.

    Article  PubMed  CAS  Google Scholar 

  69. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology 1991;41:479–486.

    Article  PubMed  CAS  Google Scholar 

  70. Mirra SS, Hart MN, Terry RD. Making the diagnosis of Alzheimer’s disease: a primer for practicing pathologist. Arch. Pathol. Lab. Med. 1993;117: 132–144.

    PubMed  CAS  Google Scholar 

  71. Sulkava R, Haltia M, Paetau A, Wikstron J, Palo J. Accuracy of clinical diagnosis in primary degenerative dementia: correlation with neuropathologic findings. J. Neurol. Neurosurg. Psychiatry 1983;46:9–13.

    Article  PubMed  CAS  Google Scholar 

  72. Joachim CL, Morris JH, Selkoe DJ. Clinically diagnosed Alzheimer’s disease: autopsy results in 150 cases. Ann. Neurol. 1988;24:50–56.

    Article  PubMed  CAS  Google Scholar 

  73. Tierney MC, Fisher RH, Lewis AJ, Zorzitto ML, Snow WG, Reid DW, Nieuwstraten P. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer’s disease: a clinicopathologic study of 57 cases. Neurology 1988;38:359–364.

    Article  PubMed  CAS  Google Scholar 

  74. Kukull WA, Larson EB, Reifier BV, Lampe TH, Yerby MS, Hughes JP. The validity of 3 clinical diagnostic criteria for Alzheimer’s disease. Neurology 1990; 40:1364–1369.

    Article  PubMed  CAS  Google Scholar 

  75. Risse SC, Raskind MA, Nochlin D, Sumi SM, Lampe TH, Bird TD, Cubberley L, Peskind ER. Neuropathological findings in patients with clinical diagnosis of probable Alzheimer’s disease. Am. J. Psychiatry 1990;147:168–172.

    PubMed  CAS  Google Scholar 

  76. Mendez M, Mastri AR, Sung JH, Frey WH. Clinically diagnosed Alzheimer’s disease: neuropathologic findings in 650 cases. Alzheimer Dis. Assoc. Disord. 1992;6:35–43.

    Article  PubMed  CAS  Google Scholar 

  77. Blacker D, Albeit MS, Bassett SS, Go RCP, Harrell LE, Folstein MF. Reliability and validity of NINCDS-ADRDA criteria for Alzheimer’s disease. Arch. Neurol. 1994;51:1198–1204.

    Article  PubMed  CAS  Google Scholar 

  78. Galasko D, Hansen LA, Katzman R, Wiederholt W, Masliah E, Terry R, Hill LR, Lessin P, Thal LJ. Clinical-neuropathological correlations in Alzheimer’s disease and related dementias. Arch. Neurol. 1994;51:888–895.

    Article  PubMed  CAS  Google Scholar 

  79. Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer’s disease. Neurology 1995;45:461–466.

    Article  PubMed  CAS  Google Scholar 

  80. Cogan DG. Visual disturbances with focal progressive dementing disease. Am. J. Ophthalmol. 1985;100:68–72.

    PubMed  CAS  Google Scholar 

  81. Brun A. Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology. Arch. Gerontol. Geriatr. 1987;6:193–208.

    Article  PubMed  CAS  Google Scholar 

  82. Hof PR, Bouras C, Constantinidis J, Morrison JH. Balint’s syndrome in Alzheimer’s disease: specific disruption of the occipito-parietal visual pathway. Brain Res. 1989;493:368–375.

    Article  PubMed  CAS  Google Scholar 

  83. Mesulam MM, Weintraub S. Spectrum of primary progressive aphasia. In Rosser MN, editor. Unusual Dementia, Baillière’s Clinical Neurology, Vol 1. 1992:583–609.

    Google Scholar 

  84. Weintraub, S, Mesulam MM. Four neuropsychological profiles in dementia. In Boiler F, Grafman J, editors. Handbook of Neuropsychology, Volume 8. Amsterdam: Elsevier Science Publishers BV, 1993:253–282.

    Google Scholar 

  85. Victoroff J, Ross GW, Benson DF, Verity MA, Vinters HV. Posterior cortical atrophy: neuropathological correlations. Arch. Neurol. 1994;51:269–274.

    Article  PubMed  CAS  Google Scholar 

  86. Ulrich J. Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer’s disease and senile dementia of Alzheimer’s type. Ann. Neurol. 1985;17:273–277.

    Article  PubMed  CAS  Google Scholar 

  87. Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, Masdeu J, Kawas C, Aronson M, Wolfson L. Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer’s disease. Neurology 38:1682–1687.

    Google Scholar 

  88. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A. Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann. Neurol. 1988; 23:138–144.

    Article  PubMed  CAS  Google Scholar 

  89. Hubbard BM, Fenton GW, Anderson JM. A quantitative histological study of early clinical and preclinical Alzheimer’s disease. Neuropathol Appl. NeurobioL 1990; 16:111–121.

    Article  PubMed  CAS  Google Scholar 

  90. Morris JC, McKeel DW, Storandt M, Rubin EH, Price JL, Grant EA, Ball MJ, Berg L. Very mild Alzheimer’s disease: informant-based clinical, psychometric and pathological distinction from normal aging. Neurology 1991;41:469–478.

    Article  PubMed  CAS  Google Scholar 

  91. Morris JC, Storandt M, McKeel DW, Rubin EH, Price JI, Grant EA, Berg L. Cerebral amyloid deposition and diffuse plaques in “normal” aging: evidence for presymptomatic and very mild Alzheimer’s disease. Neurology 1996;46:707–719.

    Article  PubMed  CAS  Google Scholar 

  92. Johansson K, Bogdanovic N, Kalimo H, Winblad B, Viitanen M. Alzheimer’s disease and apolipoprotein E e4 allele in older drivers who died in automobile accidents. Lancet 1997;349:1143–1144.

    Article  PubMed  CAS  Google Scholar 

  93. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the gray matter of elderly subjects. Br. J. Psychiatry 1968;114:797–811.

    Article  PubMed  CAS  Google Scholar 

  94. Delaere P, Duyckaerts C, Brion JP, Poulian V, Hauw J-J. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta Neuropathol 1989;77:645–653.

    Article  PubMed  CAS  Google Scholar 

  95. DeKosky ST, Scheff SW. Synapse loss in the frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Ann. Neurol. 1990;27:457–464.

    Article  Google Scholar 

  96. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitiive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991;30:572–580.

    Article  PubMed  CAS  Google Scholar 

  97. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 1992;42:631–639.

    Article  PubMed  CAS  Google Scholar 

  98. Nagy Z, Esiri MM, Jobst KA, Morris JH, King EMF, McDonald B, Litchfield S, Smith A, Barnetson L, Smith AD. Relative roles of plaques and tangles in the dementia of Alzheimer’s disease: correlations using three sets of neuropathological criteria. Dementia 1995;6:21–31.

    PubMed  CAS  Google Scholar 

  99. Gibb WRG, Lees AJ. Pathological clues to the cause of Parkinson’s disease. In Marsden CD, Fahn S, editors. Movement Disorders 3. Oxford: Butterworth-Heinemann Ltd., 1994;147–166.

    Google Scholar 

  100. Hughes CP, Berg L, Danziger W, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br. J. Psychiatry 1982;140:566–572.

    Article  PubMed  CAS  Google Scholar 

  101. Gomez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J. Neurosci. 1996;16:4491–4500.

    PubMed  CAS  Google Scholar 

  102. Stern Y, Alexander GE, Prohovnik I, Mayeux R. Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer’s disease. Ann. Neurol. 1992;32:371–375.

    Article  PubMed  CAS  Google Scholar 

  103. Evans DA, Beckett LA, Albert MS, Hebert LE, Scherr PA, Funkenstein HH, Taylor JO. Level of education and change in cognitive function in a community population of older persons. Ann. Epidemiol. 1993;3:71–77.

    Article  PubMed  Google Scholar 

  104. Katzman R. Education and the prevalence of dementia and Alzheimer’s disease. Neurology 1993;43:13–20.

    Article  PubMed  CAS  Google Scholar 

  105. Mortimer JA, Graves AB. Education and other socioeconomic determinants of dementia and Alzheimer’s disease. Neurology 1993;43(Suppl 4):S39-S44.

    Google Scholar 

  106. Alexander GE, Furey ML, Grady CL, Pietrini P, Brady DR, Mentis M J, Schapiro MB. Association of premorbid intellectual function with cerebral metabolism in Alzheimer’s disease: implications for the cognitive reserve hypothesis. Am. J. Psychiatry 1997;154:165–172.

    PubMed  CAS  Google Scholar 

  107. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease: the nun study. JAMA 1997;277:813–817.

    Article  PubMed  CAS  Google Scholar 

  108. Haxby JV, Grady CL, Duara R, Schlageter N, Berg G, Rapoport SI. Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer’s-type dementia. Arch. Neurol. 1986;43:882–885.

    Article  PubMed  CAS  Google Scholar 

  109. Katzman R, Aronson M, Fuld P, Kawas C, Brown T, Morgenstern H, Frishman W, Gidez L, Eder H, Ooi WL. Development of dementing illness in an 80-year old volunteer cohort. Ann. Neurol. 1989;25:317–324.

    Article  PubMed  CAS  Google Scholar 

  110. Coyle JT, Oster-Granite ML, Gearhart JD. The neurobiologie consequences of Down syndrome. Brain Res. Bull. 1986;16:773–787.

    Article  PubMed  CAS  Google Scholar 

  111. Lai F, Williams RS. A prospective study of Alzheimer disease in Down syndrome. Arch. Neurol. 1989;46:849–853.

    Article  PubMed  CAS  Google Scholar 

  112. Mann DMA, Yuonis N, Jones D, Stoddart RW. The time course of pathological events in Down’s syndrome with particular reference to the involvement of microglial cells and deposits of B/A4. Neurodegeneration 1992;1:201–205.

    Google Scholar 

  113. Grundman M, Petersen RC, Morris JC, Ferris S, Sano M, Farlow MR, Doody RS, Galasko D, Ernesto C, Thomas RG, Thai LJ, the ADCS Cooperative Study. Rate of dementia of the Alzheimer type (DAT) in subjects with mild cognitive impairment. Neurology 1996;46:A403.

    Article  Google Scholar 

  114. Tomlinson BE, Blessed G, Roth M. Observations of the brains of demented old people. J. Neurol. Sei. 1970;11:205–242.

    Article  CAS  Google Scholar 

  115. Brun A, Gustafson I. Distribution of cerebral degeneration in Alzheimer’s disease: a clinico-pathological study. Arch. Psychiatry 1976;223:15–33.

    Article  CAS  Google Scholar 

  116. Hooper MW, Vogel FS. The limbic system in Alzheimer’s disease: a neuropathology investigation. Am. J. Pathol. 1976;85:1–19.

    Google Scholar 

  117. Wilcock GK, Esiri MM. Plaques, tangles, and dementia: a quantitative study. J. Neurol. Sei. 1982;56:343–356.

    Article  CAS  Google Scholar 

  118. Foster NL, Chase TN, Mansi L, Brooks R, Fedio P, Patronas NJ, DiChiro G. Cortical abnormalities in Alzheimer’s disease. Ann. Neurol. 1984;16:649–654.

    Article  PubMed  CAS  Google Scholar 

  119. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation. Science 1984;225:1168–1170.

    Article  PubMed  CAS  Google Scholar 

  120. Ball MJ, Fisman M, Hachinski V, Blume W, Fox A, Krai VA, Kirshen AJ, Fox H, Merskey H. A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 1985;1:14–16.

    Article  PubMed  CAS  Google Scholar 

  121. Cutler NR, Haxby JV, Duara R, Grady CL, Kay AD, Kressler RM, Sundaram M, Rapaport SI. Clinical history, brain metabolism, and neuropsychological function in Alzheimer’s disease. Ann. Neurol. 1985;18:298–309.

    Article  PubMed  CAS  Google Scholar 

  122. Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease. Cereb. Cortex 1991;1:103–116.

    Article  PubMed  CAS  Google Scholar 

  123. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta NeuropathoL 1991;82:239–259.

    Article  PubMed  CAS  Google Scholar 

  124. Price JL, Davis PB, Morris JC, White DL. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer’s disease. Neurobiol Aging 1991;12:295–312.

    Article  PubMed  CAS  Google Scholar 

  125. Neary D, Snowden JS, Northen B, Goulding P. Dementia of frontal lobe type. /. Neurol Neurosurg. Psychiatry 1988;51:353–361.

    Article  CAS  Google Scholar 

  126. Miller BL, Cummings JL, Villanueva-Meyer J, Boone K, Mehringer CM, Lesser IM, Mena I. Frontal lobe degeneration: clinical, neuropsychological and SPECT characteristics. Neurology 1991;41:1374–1382.

    Article  PubMed  CAS  Google Scholar 

  127. Lund and Manchester Groups. Consensus statement: clinical and neuropathological criteria for frontotemporal dementia. J. Neurol. Neurosurg. Psychiatry 1994; 57:416–418.

    Article  Google Scholar 

  128. Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G, Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME, Clerget-Darpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T, Lannfelt L, Rommens JM, St. George-Hyslop PH. Alzheimer’s disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum. Mol. Genet. 1996;5:985–988.

    Article  PubMed  CAS  Google Scholar 

  129. Cruts M, Van Broeckhoven C. Presenilin mutations in Alzheimer’s disease. Hum. Mutat. 1998;11:183–190.

    Article  PubMed  CAS  Google Scholar 

  130. Brodaty H. Consensus statement on predictive testing for Alzheimer’s disease and associated disorders. Alzheimer Dis. Assoc. Disord. 1995;9:182–187.

    PubMed  CAS  Google Scholar 

  131. Statement on the use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. JAMA 1995;274:1627–1629.

    Article  Google Scholar 

  132. Relkin NR, Kwon YJ, Tsai J, Grandy S. The National Institute on Aging/ Alzheimer’s Association recommendations on the application of apolipoprotein e genotyping to Alzheimer’s disease. Ann NY Acad Sei 1998;802:149–176.

    Article  Google Scholar 

  133. Post SG, Whitehouse PJ, Binstock RH, Bird TD, Eckert SK, Farrer LA, Fleck LM, Gaines AD, Juengst ET, Karlinsky H, Miles S, Murray TH, Quaid KA, Relkin NR, Roses AD, St. George-Hyslop PH, Sachs GA, Steinbock B, Truschke EF, Zinn AB. The clinical introduction of genetic testing for Alzheimer’s disease: an ethical perspective. JAMA 1997;277:832–836.

    Article  PubMed  CAS  Google Scholar 

  134. Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang M-X, Phelps CH. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer’s disease. N Engl. J. Med. 1998;338:506–511.

    Article  PubMed  CAS  Google Scholar 

  135. Wade JPH, Mirsen TR, Hachinski VC, Fisman M, Lau C, Merskey H. The clinical diagnosis of Alzheimer’s disease. Arch. Neurol. 1987;44:24–29.

    Article  PubMed  CAS  Google Scholar 

  136. Brust JCM. Vascular dementia is overdiagnosed. Arch. Neurol. 1988;45:799–801.

    Article  PubMed  CAS  Google Scholar 

  137. Victoroff J, Mack WJ, Lyness SA, Chui HC. Multicenter clinicopathological correlation in dementia. Am. J. Psychiatry 1995;152:1476–1484.

    PubMed  CAS  Google Scholar 

  138. Hulette C, Nochlin D, McKeel D, Morris JC, Mirra SS, Sumi SM, Heyman A. Clinical-neuropathologic findings in multii-infarct dementia: a report of six au-topsied cases. Neurology 1997;48:668–672.

    Article  PubMed  CAS  Google Scholar 

  139. Hakim AM, Mathieson G. Dementia in Parkinson disease: a neuropathologic study. Neurology 1979;29:1209–1214.

    Article  PubMed  CAS  Google Scholar 

  140. Boiler F, Passafiume D, Keefe NC, Rogers K, Morrow L, Kim Y. Visuospatial impairment in Parkinson’s disease: role of perceptual and motor factors. Arch. Neurol 1984;41:485–490.

    Article  Google Scholar 

  141. Katzman R. Should a major imaging procedure (CT or MRI) be required in the workup of dementia?: an affirmative view. J. Fam. Pract. 1990;31:401–410.

    PubMed  CAS  Google Scholar 

  142. Bird T. Apolipoprotein E genotyping in the diagnosis of Alzheimer’s disease: a cautionary view. Ann. Neurol. 1995;38:2–3.

    Article  PubMed  CAS  Google Scholar 

References Cited in Footnote on Page 4

  1. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hip-pocampal neuronal loss in normal ageing and Alzheimer’s disease. Lancet 1994; 344:769–772.

    Article  PubMed  CAS  Google Scholar 

  2. Scheltens Ph, Barkhof F, Leys D, Wolters E Ch, Ravid R, Kamphorst W. Histopathologic correlates of white matter changes on MRI in Alzheimer’s disease and normal aging. Neurology 1995;45:883–888.

    Article  PubMed  CAS  Google Scholar 

  3. Morris JC, Storandt M, McKeel DW, et al. Cerebral amyloid deposition and diffuse plaques in “normal” aging: evidence for presymptomatic and very mild Alzheimer’s disease. Neurology 1996;46:707–719.

    Article  PubMed  CAS  Google Scholar 

  4. Mukaetova-Ladinska EB, Harrington CR, Roth M, Wischik CM. Alterations in tau protein metabolism during normal aging. Dementia 1996;7:95–103.

    PubMed  CAS  Google Scholar 

  5. Simic G, Kostovic I, Winblad B, Bogdanovic N. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer’s disease. J. Comp. Neurol. 1997;379:482–494.

    Article  PubMed  CAS  Google Scholar 

  6. Wang D, Munoz DG. Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer’s disease and normal aged brain. J. Neuropathol. Exp. Neurol. 1995;54:548–556.

    Article  PubMed  CAS  Google Scholar 

  7. Troncoso JC, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Śmiałek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer’s disease. Ann. Neurol. 1998;43:673–676.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Kirk R. Daffner
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  2. Leonard F. M. Scinto
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  1. Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Leonard F. M. Scinto PhD  & Kirk R. Daffner MD  & 

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Daffner, K.R., Scinto, L.F.M. (2000). Early Diagnosis of Alzheimer’s Disease. In: Scinto, L.F.M., Daffner, K.R. (eds) Early Diagnosis of Alzheimer’s Disease. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-005-6_1

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