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Cardiovascular Chronobiology and Chronopharmacology

Importance of Timing of Dosing

  • Chapter
Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Heart rate was among the earliest physiological functions reported not to be constant throughout the 24 h of a day (1). As early as at the beginning of the 17th century, daily variations in pulse rate, as well as a rapid increase on awakening, were described (2). In the 18th and 19th centuries, general observations as well as detailed data on daily variations in pulse rate and pulse quality were reported (3–11). The pulse of a healthy subject as determined in the late afternoon was even proposed as a easily available “metronom” to be used by musicians (12) (see Fig. 1). The metronom itself was not invented until 1816 by Mälzel.

This chapter is dedicated to the memory of Jürgen Aschoff (1913–1998).

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  1. Björn Lemmer MD
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  1. Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, CT, USA

    William B. White MD (Professor of Medicine) (Professor of Medicine)

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Lemmer, B. (2001). Cardiovascular Chronobiology and Chronopharmacology. In: White, W.B. (eds) Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-004-9_12

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  • DOI: https://doi.org/10.1007/978-1-59259-004-9_12

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