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Nitric Oxide and the Cardiovascular System pp 51–67Cite as

Regulation of Gene Expression by Nitric Oxide

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Nitric oxide (NO·) and related chemical species have emerged as ubiquitous cellular messengers. This smallest known mammalian biological signaling molecule plays a crucial role in human physiology. NO· is synthesized by the enzyme nitric oxide synthase (NOS) and can assume several chemical forms, each of which has its own reactive specificity toward cellular targets. The resulting interaction initiates many signaling events in the cell. NO·-induced signal transduction and gene expression influences various physiological events including vasodilation, cytotoxicity, inflammation, and synaptic plasticity.

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Authors
  1. Ami A. Deora
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  2. Harry M. Lander
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Editors and Affiliations

  1. Boston University Medical Center, Boston, MA, USA

    Joseph Loscalzo MD, PHD  & Joseph A. Vita MD  & 

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Deora, A.A., Lander, H.M. (2000). Regulation of Gene Expression by Nitric Oxide. In: Loscalzo, J., Vita, J.A. (eds) Nitric Oxide and the Cardiovascular System. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-002-5_4

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  • DOI: https://doi.org/10.1007/978-1-59259-002-5_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-101-1

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