Abstract
As the duration of orbital missions and the size of the crews increase and as plans are made for exploration beyond Earth’s orbit, the ability to provide space crews with a healthy and comfortable living environment grows ever more complex. Advanced environmental control systems will be needed for both planetary exploration missions and permanent settlements beyond Earth’s atmosphere. New technologies will be needed to enhance water reclamation, produce O2, and remove carbon dioxide (CO2). The primary requirements for such a system will be minimal power usage and volume, robust autonomous operation, and a closed-loop design that minimizes reliance on stored consumables. Once we venture beyond low Earth orbit (LEO), the risks associated with radiation increase, the capability for frequent resupply diminishes, and medical assistance and evacuation become less available. Life support systems must become more “closed loop,” more robust, more efficient, more operationally simplified, more automated, and more reliable—while simultaneously requiring less energy-intensive, less massive, and less expensive technology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Jones W, Ingelfinger A. Atmospheric control. In: Parker J, West V, editors. Bioastronautics data book. 2nd ed. Washington: National Aeronautics and Space Administration; 1973. p. 807–846. NASA SP-3006.
Malkin V. Barometric pressure and gas composition of spacecraft cabin air. In: Sulzman FM, Genin AM, editors. Life support and habitability, vol. II. Washington: American Institute of Aeronautics and Astronautics; 1993. p. 1–36.
Graf J, Finger B, Daues K. Life Support systems for the space environment: basic tenets for designers, Rev. A, June 27, 2002. http://advlifesupport.jsc.nasa.gov.
Norcross J, Norsk P, Law J, et al. Effects of the 8 psia/32% O2 atmosphere on the human in the spaceflight environment. NASA/TM-2013-217377.
International Civil Aviation Organization. Manual of the ICAO standard atmosphere. 2nd ed. Montreal: ICAO; 1964.
Billings C. Atmosphere. Chapter 2. In: Parker J, West V, editors. Bioastronautics data book. 2nd ed. Washington: National Aeronautics and Space Administration; 1973. p. 1–34. NASA SP-3006.
Murray DH, Pilmanis AA, Blue RS, et al. Pathophysiology, prevention, and treatment of ebullism. Aviat Space Environ Med. 2013;84:89–96.
Kolesari G, Kindwall E. Survival following accidental decompression to an altitude greater than 74,000 ft (22,555 m). Aviat Space Environ Med. 1982;53(12):1211–4.
Harland D. The story of space station Mir. Chichester, UK: Springer Praxis Books; 2005.
Smith AM. Acute hypoxia and related symptoms on mild exertion at simulated altitudes below 3048 m. Aviat Space Environ Med. 2007;78(10):979–84.
Netzer N, Kingman S, Faulhaber M, Gatterer H, Burtscher M. Hypoxia-related altitude illness. J Travel Med. 2013;20(4):247–55.
Petrassi FA, Hodkinson PD, Walters PL, Gaydos SJ. Hypoxic hypoxia at moderate altitudes: review of the state of the science. Aviat Space Environ Med. 2012;83(10):975–84.
Gilbert-Kawai ET, Milledge JS, Grocott MP, Martin DS. King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude. Physiology (Bethesda). 2014;29(6):388–402.
Goldfarb-Rumyantzev AS, Alper SL. Short-term responses of the kidney to high altitude in mountain climbers. Nephrol Dial Transplant. 2014;29(3):497–506.
Federal Aviation Regulations. Federal Aviation Administration. 2017. https://www.faa.gov/regulations_policies/faa_regulations/.
Wessel JH III, Schaefer CM, Thompson MS, Norcross JR, Bekdash OS. Retrospective evaluation of clinical symptoms due to mild hypobaric hypoxia exposure in microgravity. Aerosp Med Hum Perf. 2018;89(9):1–6.
Montgomery AB, Luce JM, Murray JF. Retrosternal pain is an early indicator of oxygen toxicity. Am Rev Respir Dis. 1989;139:1548–50.
Caldwell PR, Lee WL Jr, Schildkraut HS, et al. Changes in lung volume, diffusing capacity, and blood gases in men breathing oxygen. J Appl Physiol. 1966;21:1477–83.
Clark J. Therapeutic and toxic effects of hyperbaric oxygenation. In: Crystal R, West J, et al., editors. The lung: scientific foundations. New York: Raven Press Ltd.; 1991. p. 2123–31.
Robertson W, Hargreaves J, Herlocher J, et al. Physiologic response to increased oxygen partial pressure II: respiratory studies. Aerospace Med. 1964;35:618–22.
West JB. Fire hazard in oxygen-enriched atmospheres at low barometric pressures. Aviat Space Environ Med. 1997;68(2):159–62.
Michel EL, Waligora JM, Horrigan DJ, Shumate WH. Environmental factors. Chapter 5. In: Johnston RS, Dietlein LF, Berry CA, editors. Biomedical results of Apollo. Washington: Scientific and Technical Information Office, National Aeronautics and Space Administration; 1975.
Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA. Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature. 2015;527(7577):240–4.
Raichle ME, Gusnard DA. Appraising the brain’s energy budget. Proc Natl Acad Sci U S A. 2002;99(16):10237–9.
Lataste X. The blood-brain barrier in hypoxia. Int J Sports Med. 1992;13:S45–7.
Neubauer J, Melton J, Edelman N. Modulation of respiration during brain hypoxia. J Appl Physiol. 1990;68:441–51.
Hammond M, Gale GE, Kapitan K, et al. Pulmonary gas exchange in humans during normobaric hypoxic exercise. J Appl Physiol. 1986;16:1749–57.
Wagner PD, Gale GE, Moon RE, et al. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol. 1986;61:260–70.
Wood S. Interactions between hypoxia and hypothermia. Annu Rev Physiol. 1991;53:71–85.
Vaity C, Al-Subaie N, Cecconi M. Cooling techniques for targeted temperature management post-cardiac arrest. Crit Care. 2015;19:103.
Scirica BM. Therapeutic hypothermia after cardiac arrest. Circulation. 2013;127:244–50.
Yoneda I, Tomoda M, Tokumaru O, et al. Time of useful consciousness determination in aircrew members with reference to prior altitude chamber experience and age. Aviat Space Environ Med. 2000;71:72–6.
Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. J Neurosci. 2015;35(4):1773–80.
Ando S, Hatamoto Y, Sudo M, Kiyonaga A, Tanaka H, et al. The effects of exercise under hypoxia on cognitive function. PLoS One. 2013;8(5):e63630. https://doi.org/10.1371/journal.pone.0063630.
Rupp T, Jubeau M, Lamalle L, Warnking JM, Millet GY, Wuyam B, Esteve F, Levy P, Krainik A, Verges S. Cerebral volumetric changes induced by prolonged hypoxic exposure and whole-body exercise. J Cereb Blood Flow Metab. 2014;34(11):1802–9.
Ainslie PN, Subudhi AW. Cerebral blood flow and high altitude. High Alt Med Biol. 2014;15(2):133–40.
Brinchmann-Hansen O, Myhre K, Sandvik L. Retinal vessel responses to exercise and hypoxia before and after high altitude acclimatisation. Eye (Lond). 1989;3(Pt 6):768–76.
Brinchmann-Hansen O, Myhre K. Vascular response of retinal arteries and veins to acute hypoxia of 8,000, 10,000, 12,500, and 15,000 feet of simulated altitude. Aviat Space Environ Med. 1990;61(2):112–6.
Connolly DM, Barbur JL, Hosking SL, Moorhead IR. Mild hypoxia impairs chromatic sensitivity in the mesopic range. Invest Ophthalmol Vis Sci. 2008;49(2):820–7.
Horng CT, Liu CC, Wu DM, Wu YC, Chen JT, Chang CJ, Tsai ML. Visual fields during acute exposure to a simulated altitude of 7620 m. Aviat Space Environ Med. 2008;79(7):666–9.
Connolly DM, Hosking SL. Aviation-related respiratory gas disturbances affect dark adaptation: a reappraisal. Vision Res. 2006;46(11):1784–93.
San T, Polat S, Cingi C, Eskiizmir G, Oghan F, Cakir B. Effects of high altitude on sleep and respiratory system and theirs adaptations. ScientificWorldJournal. 2013;2013:241569.
Stadelmann K, Latshang TD, Tarokh L, Lo Cascio CM, Tesler N, Stoewhas AC, Kohler M, Bloch KE, Huber R, Achermann P. Sleep respiratory disturbances and arousals at moderate altitude have overlapping electroencephalogram spectral signatures. J Sleep Res. 2014;23(4):463–8.
Latshang TD, Lo Cascio CM, Stöwhas AC, Grimm M, Stadelmann K, Tesler N, Achermann P, Huber R, Kohler M, Bloch KE. Are nocturnal breathing, sleep, and cognitive performance impaired at moderate altitude (1,630-2,590 m)? Sleep. 2013;36(12):1969–76.
Burgess KR, Lucas SJ, Shepheard K, et al. Influence of cerebral blood flow on central sleep apnea at high altitude. Sleep. 2014;37(10):1679–87.
de Aquino Lemos V, Antunes HK, dos Santos RV, Lira FS, Tufik S, de Mello MT. High altitude exposure impairs sleep patterns, mood, and cognitive functions. Psychophysiology. 2012;49(9):1298–306.
West JB. Tolerance to severe hypoxia: lessons from Mt. Everest. Acta Anaesthesiol Scand Suppl. 1990;34:18–23.
Sutton J, Reeves J, Wagner P, et al. Operation Everest II: oxygen transport during exercise at extreme hypoxia. J Appl Physiol. 1988;64:1309–21.
Agostoni P, Swenson ER, Bussotti M, Revera M, Meriggi P, Faini A, Lombardi C, Bilo G, Giuliano A, Bonacina D, Modesti PA, Mancia G, Parati G. High-altitude exposure of three weeks duration increases lung diffusing capacity in humans. J Appl Physiol (1985). 2011;110(6):1564–71.
Farias JG, Jimenez D, Osorio J, et al. Acclimatizaation to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile. Biol Res. 2013;46(1):59–67.
Lambertsen C. Hypoxia, altitude and acclimatization. In: Mountcastle V, editor. Medical physiology. 14th ed. St. Louis: Mosby; 1980.
Hackett P, Rabold M. High-altitude medical problems. In: Tintinalli J, Ruiz E, Krome R, editors. Emergency medicine: a comprehensive study guide. 4th ed. New York: McGraw-Hill Company; 1996.
Scholz H, Schurek H, Eckardt K, Bauer C. Role of erythropoietin in adaptation to hypoxia. Experientia. 1990;46:1197–201.
Young AJ, Young PM. Human acclimatization to high terrestrial altitude. In: Pandolf K, Sawka M, Gonzalez R, editors. Human performance physiology and environmental medicine at terrestrial extremes. Carmel: Cooper Publishing Group; 1988.
Hochachka P. Mechanism and evolution of hypoxia-tolerance in humans. J Exp Biol. 1998;201:1243–54.
Bebout D, Story D, Roca J, et al. Effects of altitude acclimatization on pulmonary gas exchange during exercise. J Appl Physiol. 1989;67:2286–95.
Appenzeller O, Martignoni E. The autonomic nervous system and hypoxia: mountain medicine. J Auton Nerv Syst. 1996;57:1–12.
Conkin J. The Mars project: avoiding decompression sickness on a distant planet. Houston: NASA, Lyndon B. Johnson Space Center; 2000. NASA TM 2000-210188.
Fenton L, Beck G, Djali S, Robinson M. Hypothermia induced by hyperbaric oxygen is not blocked by serotonin antagonists. Pharmacol Biochem Behav. 1993;44:357–64.
Waligora JM, Horrigan DJ, Nicogossian A. The physiology of spacecraft and space suit atmosphere selection. Acta Astronautica. 1991;23:171–7.
Nakae H, Tanaka H, Inaba H. Failure to clear casts and secretions following inhalation injury can be dangerous: report of a case. Burns. 2001;27:189–91.
Robinson L, Miller RH. Smoke inhalation injuries. Am J Otolaryngol. 1986;7:375–80.
Waligora J, Powell M, Sauer R. Spacecraft life-support systems. In: Nicogossian AE, Huntoon CL, Pool SL, editors. Space physiology and medicine. 3rd ed. Philadelphia: Lea & Febiger; 1994. p. 109–27.
National Oceanic and Atmospheric Administration. https://www.esrl.noaa.gov/research/themes/carbon/. Accessed 16 Aug 2018.
Eckart P. Spaceflight life support and biospherics. Torrance: Microcosm Press; 1996.
Newkirk D. Almanac of Soviet manned space flight. Houston: Gulf Publishing Co; 1990.
Rahn H, Fenn WO. The oxygen—carbon dioxide diagram. WADC-TR-53-255, Wright-Patterson Air Force Base, Ohio; 1953.
Son CH, Zapata JL, Lin CH. Investigation of airflow and accumulation of carbon dioxide in the Service Module crew quarters. Society of Automotive Engineers. Technical Paper No. 2002-01-2341; 2002.
Law J, Young M, Alexander D, Mason S, Wear ML, Méndez CM, Stanley D, Meyers Ryder V, Van Baalen M. Carbon dioxide physiological training at NASA. Aerosp Med Hum Perform. 2017;88(10):1–6.
Barer GR, Howard P, Shaw JW. Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia. J Physiol (Lond). 1970;211:139–55.
Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest. 1948;27:484–92.
Reivich M. Arterial PCO2 and cerebral hemodynamics. Am J Physiol. 1964;206:25–35.
Pingree BJW. Acid-base and respiratory changes after prolonged exposure to 1% carbon dioxide. Clin Sci Mol Med. 1977;52:67–74.
Schaefer KE, Hastings BJ, Carey CR, Nicolas G Jr. Respiratory acclimatization to carbon dioxide. J Appl Physiol. 1963;18(6):1071–8.
Elliott AR, Prisk GK, Schöllmann C, Hoffmann U. Hypercapnic ventilator response in humans before, during, and after 23 days of low level CO2 exposure. Aviat Space Environ Med. 1998;69:391–6.
Sliwka U, Krasney JA, Simon SG, Schmidt P, Noth J. Effects of sustained low-level elevations of carbon dioxide on cerebral blood flow and autoregulation of the intracerebral arteries in humans. Aviat Space Environ Med. 1998;69(3):299–306.
Messier AA, Heyder E, Braithwaite WR, McCluggage C, Peck A, Schaefer KE. Calcium, magnesium, and phosphorus metabolism, and parathyroid-calcitonin function during prolonged exposure to elevated CO2 concentrations on submarines. Undersea Biomed Res. 1979;6:S57–70.
Schaefer KE. Physiological stresses related to hypercapnia during patrols on submarines. Undersea Biomed Res. 1979;6:S15–47.
Drummer C, Friedel V, Borger A, Stormer IR, Wolter S, Zittermann A, Wolfram G, Heer M. Effects of elevated carbon dioxide environment on calcium metabolism in humans. Aviat Space Environ Med. 1998;69:291–8.
Satish U, Mendell MJ, Shekhar K, et al. Is CO2 an indoor pollutant? Direct effects of low-to-moderate CO2 concentrations on human decision-making performance. Environ Health Perspect. 2012;120(12):1671–7. https://doi.org/10.1289/ehp.1104789.
Rodeheffer CD, Chabal S, Clarke JM, Fothergill DM. Acute exposure to low-to-moderate carbon dioxide levels and submariner decision making. Aerospace Med Human Perf. 2018;89(6):520–5.
Ryder VE, Scully RR, Alexander DJ, Young M, Thomas G, et al., editors. Effects of acute exposure to carbon dioxide upon cognitive functions. 2017 NASA Human Research Program Investigators’ Workshop, 23–26 January, 2017. Galveston, TX.
Stankovic A, Alexander D, Oman CM, Schneiderman J. A review of cognitive and behavioral effects of increased carbon dioxide exposure in humans. Hanover: National Aeronautics and Space Administration; 2016. NASA/TM-2016-219277.
Law J, Van Baalen M, Foy M, Mason SS, Mendez C, Wear ML, Meyers VE, Alexander D. Relationship between carbon dioxide levels and reported headaches on the international space station. J Occup Environ Med. 2014;56(5):477–83.
Law J, Watkins S, Alexander D. In-flight carbon dioxide exposures and related symptoms: association, susceptibility, and operational implications. Hanover: National Aeronautics and Space Administration; 2010. NASA/TP-2010- 216126.
Polyakov VV, Lacota NG, Gundel A. Human thermohomeostasis onboard “Mir” and in simulated microgravity studies. Acta Astronautica. 2001;49:137–43.
Fortney SM, et al. Body temperature and thermoregulation during submaximal exercise after 115-day spaceflight. Aviat Space Environ Med. 1998;69:137–41.
Stahn AC, Werner A, Optaz O, et al. Increased core body temperature in astronauts during long-duration space missions. Sci Rep. 2017;7, Article No. 16180. https://doi.org/10.1038/s41598-017-15560-w.
Wieland PO. Designing for human presence in space: an introduction to environmental control and life support systems. Marshall Space Flight Center, AL: NASA Scientific and Technical Information Program; 1994. Chapter 5. NASA RP-1324.
Churchill SE, editor. Fundamentals of space life sciences. Malabar: Krieger Publishing Co; 1997.
Rippstein WJ, Schneider HJ. Toxicological aspects of the Skylab program. In: Johnson RS, Dietlein LF, editors. Biomedical results from Skylab. Washington: U.S. Government Printing Office; 1977. p. 70–3. NASA SP-377.
ASME AG-1-2003 code on nuclear air and gas treatment. American Society of Mechanical Engineers, New York 10017-2392; 2003.
Wieland PO. Designing for human presence in space: an introduction to environmental control and life support systems. Marshall Space Flight Center, AL: NASA Scientific and Technical Information Program; 1994. Appendix C, C.2. NASA RP-1324.
Wieland PO. Designing for human presence in space: an introduction to environmental control and life support systems. Marshall Space Flight Center, AL: NASA Scientific and Technical Information Program; 1994. 2.3. NASA RP-1324.
Link MM. Space medicine in project Mercury. Washington: NASA Scientific and Technical Information Division; 1965. NASA SP-4003.
Johnston RS, Dietlein LF, Berry CA, editors. Biomedical results of Apollo. Washington: NASA Scientific and Technical Information Division; 1975. NASA SP-368.
Hacker BC, Grimwood JM. On the shoulders of Titans: a history of project Gemini. Washington: NASA Scientific and Technical Information Division; 1977. NASA SP-4203.
Collins M. Carrying the fire: an astronaut’s journeys. New York: Farrar, Straus, and Giroux, Inc.; 1974.
Nicogossian A, Mohler S, Gazenko O, Grigoriev AI, series editors. Space biology and medicine: Joint U.S./Russian Publication in Five Volumes. p. 24.
Ezell EC, Ezell LN. The partnership: a history of the Apollo-Soyuz test project. Washington: NASA Scientific and Technical Information Division; 1978. NASA SP-4209.
Williams DE, Dake JR. International Space Station environmental control and life support system status for the prior year: 2010-2011. In: 42nd International Conference on Environmental Systems, 15–19 July 2012. San Diego: American Institute of Aeronautics and Astronautics.
Hackett PH, Roach RC. High-altitude medicine. In: Auerbach PS, editor. Wilderness medicine. 3rd ed. St. Louis: Mosby Year Book; 1995. p. 3.
Rousseau J. Atmospheric control systems for space vehicles. Report No. ASD-TDR-62-527. Los Angeles: AiResearch Manufacturing Division; 1963.
NASA Space Flight Human-System Standard, vol 2. Human factors, habitability, and environmental health. Section 6: natural and induced environments. NASA-STD-3001, vol 2, Rev A; 2015.
Pickard JS, Gradwell DP. Respiratory physiology and protection against hypoxia. In: Davis JR, et al., editors. Fundamentals of aerospace medicine. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2008. p. 64.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Science+Business Media, LLC, part of Springer Nature
About this chapter
Cite this chapter
Beck, G., Law, J., Bacal, K., Barratt, M.R. (2019). Hypoxia, Hypercarbia, and Atmospheric Control. In: Barratt, M., Baker, E., Pool, S. (eds) Principles of Clinical Medicine for Space Flight. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9889-0_3
Download citation
DOI: https://doi.org/10.1007/978-1-4939-9889-0_3
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-9887-6
Online ISBN: 978-1-4939-9889-0
eBook Packages: MedicineMedicine (R0)