Ancillary Diagnostic Tests in the Diagnosis of Cutaneous Soft Tissue Neoplasms

  • Andrew L. FolpeEmail author


This chapter will cover selected applications of immunohistochemistry (IHC) in the diagnosis of soft tissue tumors of the skin. This section will emphasize applications of IHC to common differential diagnoses in cutaneous soft tissue pathology, including (1) pleomorphic spindle cell tumors; (2) epithelioid malignant neoplasms; (3) monomorphic spindle cell tumors; (4) “fibrohistiocytic” or “histiocytoid” lesions; (5) small, round blue cell tumors; and (6) adipocytic tumors. It is not possible in this relatively brief section to provide a detailed discussion of each antigen or of every rare soft tissue tumor that may occasionally be seen in the skin, and the reader is referred to the relevant chapters in this book for more detailed discussions of specific entities.


Immunohistochemistry Differential diagnosis FISH Sarcoma Carcinoma Melanoma Sarcoma Vascular tumor 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA

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