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Nerve Sheath and Related Tumors

  • Steven D. BillingsEmail author
Chapter

Abstract

This chapter reviews the wide spectrum of cutaneous nerve sheath tumors. The vast majority are benign tumors, including neurofibromas, schwannomas, perineuriomas, granular cell tumors, and various neuroma subtypes. Malignant granular cell tumor, malignant peripheral nerve sheath tumor, and Ewing sarcoma, a malignant neuroectodermal tumor, are also rarely encountered in the skin. Diagnostic criteria and practical considerations are emphasized.

Keywords

Neurofibroma Schwannoma Perineurioma Granular cell tumor Solitary circumscribed neuroma Meningioma Malignant peripheral nerve sheath tumor Ewing sarcoma 

Selected References

  1. 1.
    Abbas O, Bhawan J. Cutaneous plexiform lesions. J Cutan Pathol. 2010;37(6):613–23.PubMedCrossRefGoogle Scholar
  2. 2.
    Allison KH, Patel RM, Goldblum JR, Rubin BP. Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis. Am J Clin Pathol. 2005;124(5):685–92.PubMedCrossRefGoogle Scholar
  3. 3.
    Avninder S, Ramesh V, Vermani S. Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg. Dermatol Online J. 2007;13(2):14.PubMedGoogle Scholar
  4. 4.
    Erstine EM, Ko JS, Rubin BP, McKenney JK, Goldblum JR, Billings SD. Broadening the anatomic landscape of sclerosing perineurioma: A series of 5 cases in nonacral sites. Am J Dermatopathol. 2016 Nov 11. [Epub ahead of print] PubMed.Google Scholar
  5. 5.
    Evans HL. Sporadic superficial diffuse neurofibromas with repeated local recurrence over many years and a tendency toward malignant change: a report of 3 cases. Am J Surg Pathol. 2013;37(7):987–94.PubMedCrossRefGoogle Scholar
  6. 6.
    Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22(7):779–94.PubMedCrossRefGoogle Scholar
  7. 7.
    Fletcher CD, Theaker JM. Digital pacinian neuroma: a distinctive hyperplastic lesion. Histopathology. 1989;15(3):249–56.PubMedCrossRefGoogle Scholar
  8. 8.
    Fletcher CD, Davies SE, McKee PH. Cellular schwannoma: a distinct pseudosarcomatous entity. Histopathology. 1987;11(1):21–35.PubMedCrossRefGoogle Scholar
  9. 9.
    Fox MD, Billings SD, Gleason BC, Thomas AB, Cibull TL. Cutaneous meningioma: a potential diagnostic pitfall in p63 positive cutaneous neoplasms. J Cutan Pathol. 2013;40(10):891–5.PubMedGoogle Scholar
  10. 10.
    Goldblum JR, Beals TF, Weiss SW. Neuroblastoma-like neurilemoma. Am J Surg Pathol. 1994;18(3):266–73.PubMedCrossRefGoogle Scholar
  11. 11.
    Hart J, Gardner JM, Edgar M, Weiss SW. Epithelioid schwannomas: an analysis of 58 cases including atypical variants. Am J Surg Pathol. 2016;40(5):704–13.PubMedCrossRefGoogle Scholar
  12. 12.
    Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29(7):845–58.PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Hornick JL, Bundock EA, Fletcher CD. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol. 2009;33(10):1554–61.PubMedCrossRefGoogle Scholar
  14. 14.
    Kacerovska D, Michal M, Kazakov DV. Hybrid Epithelioid Schwannoma/Perineurioma. Am J Dermatopathol. 2016;38(7):e90–2.PubMedCrossRefGoogle Scholar
  15. 15.
    Kaku Y, Fukumoto T, Louise Opada G, Anan T, Kimura T. A clinicopathologic and immunohistochemical study of 7 cases of sclerosing perineurioma. Am J Dermatopathol. 2015;37(2):122–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Kao GF, Laskin WB, Olsen TG. Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Mod Pathol. 1989;2(1):20–6.PubMedGoogle Scholar
  17. 17.
    Koutlas IG, Scheithauer BW. Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity: a review of 55 cases. Head Neck Pathol. 2010;4(1):15–26.PubMedPubMedCentralCrossRefGoogle Scholar
  18. 18.
    Lisle A, Jokinen C, Argenyi Z. Cutaneous pseudoglandular schwannoma: a case report of an unusual histopathologic variant. Am J Dermatopathol. 2011;33(5):e63–5.PubMedCrossRefGoogle Scholar
  19. 19.
    Lupton JR, Epps RE, Figueroa P, Kupiec A, Sulica VI. Plexiform neurofibroma with massive hand involvement. J Am Acad Dermatol. 2000;43(6):1136–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Luzar B, Falconieri G. Cutaneous malignant peripheral nerve sheath tumor. Surg Pathol Clin. 2017;10(2):337–43.PubMedCrossRefGoogle Scholar
  21. 21.
    Luzar B, Tanaka M, Schneider J, Calonje E. Cutaneous microcystic/reticular schwannoma: a poorly recognized entity. J Cutan Pathol. 2016;43(2):93–100.PubMedCrossRefGoogle Scholar
  22. 22.
    Macarenco RS, Ellinger F, Oliveira AM. Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med. 2007;131(4):625–36.PubMedGoogle Scholar
  23. 23.
    Machado I, Cruz J, Lavernia J, Llombart-Bosch A. Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle. Virchows Arch. 2016;468(5):527–38.PubMedCrossRefGoogle Scholar
  24. 24.
    Miedema JR, Zedek D. Cutaneous meningioma. Arch Pathol Lab Med. 2012;136(2):208–11.PubMedCrossRefGoogle Scholar
  25. 25.
    Noonan VL, Greene DJ, Brodsky G, Kabani SP. Extraneural sclerosing perineurioma of the buccal mucosa: a case report and clinicopathologic review. Head Neck Pathol. 2010;4(2):169–73.PubMedPubMedCentralCrossRefGoogle Scholar
  26. 26.
    Pérez-González YC, Pagura L, Llamas-Velasco M, Cortes-Lambea L, Kutzner H, Requena L. Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature. Am J Dermatopathol. 2015;37(4):334–40.PubMedCrossRefGoogle Scholar
  27. 27.
    Robson AM, Calonje E. Cutaneous perineurioma: a poorly recognized tumour often misdiagnosed as epithelioid histiocytoma. Histopathology. 2000;37(4):332–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Rodríguez-Peralto JL, Riveiro-Falkenbach E, Carrillo R. Benign cutaneous neural tumors. Semin Diagn Pathol. 2013;30(1):45–57.PubMedCrossRefGoogle Scholar
  29. 29.
    Rubin AI, Yassaee M, Johnson W, Elenitsas R, Zaladonis J Jr, Seykora JT. Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol. 2009;36(Suppl 1):60–5.PubMedCrossRefGoogle Scholar
  30. 30.
    Sheth S, Li X, Binder S, Dry SM. Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. Mod Pathol. 2011;24(3):343–54.PubMedCrossRefGoogle Scholar
  31. 31.
    Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E. Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. J Cutan Pathol. 2010;37(9):997–1001.PubMedCrossRefGoogle Scholar
  32. 32.
    Sundarkrishnan L, Bradish JR, Oliai BR, Hosler GA. Cutaneous cellular pseudoglandular schwannoma: an unusual histopathologic variant. Am J Dermatopathol. 2016;38(4):315–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Thomas C, Somani N, Owen LG, Malone JC, Billings SD. Cutaneous malignant peripheral nerve sheath tumors. J Cutan Pathol. 2009;36(8):896–900.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PathologyCleveland ClinicClevelandUSA

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