Skip to main content
SpringerLink
Log in

Acute Kidney Failure and Minimal Change Disease

  • Chapter
  • First Online:
Core Concepts in Acute Kidney Injury

  • 1538 Accesses

Abstract

MCD represents 95% of all cases of childhood idiopathic nephrotic syndrome (INS) and 30% of INS in adults of all ages and is not exceptional after 60 years. Albuminuria and hypoalbuminemia are accompanied by massive edema without reduction of blood volume. Renal function is moderately altered in 1/3 of patients with MCD, as foot process fusion impairs filtration of small molecules. The GFR returns to normal with remission of proteinuria. Since the early 1960s, a number of publications reported cases of acute oliguric kidney insufficiency complicating the course of MCD in adults. AKI mostly affects older patients with massive proteinuria, severe hypoalbuminemia, a background of hypertension, and arterial/arteriolar lesions on kidney biopsy. Histology reveals ischemic tubular necrosis. AKI may require dialysis for several weeks or months until treatment-induced remission allows resolution of oliguria. In rare cases AKI does not recover. Factors causing AKI in patients with MCD are diuretic-induced hypovolemia, NSAIDs, iodinated contrast media, and nephrotoxic drugs. AKI is not frequent in children with MCD in the absence of intercurrent complications. Conversely when steroid-resistant nephrotic children are hospitalized for an acute episode of hypovolemia, sepsis, peritonitis, and exposure to nephrotoxic medications and/or ACE inhibitors, AKI complicates NS in about half of them. The main goal of supportive therapy is to buy time until corticosteroids obtain a remission of proteinuria. Persistent oliguria may require a long period of dialysis. Prevention is based on early detection and treatment of infection, limited use of diuretics, and avoidance of nephrotoxic agents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cameron JS. Nephrotic syndrome in the elderly. Semin Nephrol. 1996;16:319–29.

    CAS  PubMed  Google Scholar 

  2. Haas M, Spargo BH, Wit EJ, Meehan SM. Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis. 2000;35:433–47.

    Article  CAS  PubMed  Google Scholar 

  3. Moutzouris DA, Herlitz L, Appel GB, Markowitz GS, Freudenthal B, Radhakrishnan J, D’Agati VD. Renal biopsy in the very elderly. Clin J Am Soc Nephrol. 2009;4:1073–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Uezono S, Hara S, Sato Y, Komatsu H, Ikeda N, Shimao Y, Hayashi T, Asada Y, Fujimoto S, Eto T. Renal biopsy in elderly patients: a clinicopathological analysis. Ren Fail. 2006;28:549–55.

    Article  PubMed  Google Scholar 

  5. Zech P, Colon S, Pointet P, Deteix P, Labeeuw M, Leitienne P. The nephrotic syndrome in adults aged over 60: etiology, evolution and treatment of 76 cases. Clin Nephrol. 1982;17:232–6.

    CAS  PubMed  Google Scholar 

  6. Marino F, Martorano C, Tripepi R, Bellantoni M, Tripepi G, Mallamaci F, Zoccali C. Subclinical pulmonary congestion is prevalent in nephrotic syndrome. Kidney Int. 2016;89(2):421–8.

    Article  PubMed  Google Scholar 

  7. Rostoker G, Behar A, Lagrue G. Vascular hyperpermeability in nephrotic edema. Nephron. 2000;85:194–200.

    Article  CAS  PubMed  Google Scholar 

  8. Doucet A, Favre G, Deschenes G. Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications. Pediatr Nephrol. 2007;22:1983–90.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bhave G, Neilson EG. Body fluid dynamics: back to the future. J Am Soc Nephrol. 2011;22:2166–81.

    Article  CAS  PubMed  Google Scholar 

  10. Vande Walle JG, Donckerwolcke RA. Pathogenesis of edema formation in the nephrotic syndrome. Pediatr Nephrol. 2001;16:283–93.

    Article  CAS  PubMed  Google Scholar 

  11. Koomans HA, Kortlandt W, Geers AB, Dorhout Mees EJ. Lowered protein content of tissue fluid in patients with the nephrotic syndrome: observations during disease and recovery. Nephron. 1985;40:391–5.

    Article  CAS  PubMed  Google Scholar 

  12. Koomans HA, Geers AB, Dorhout Mees EJ, Kortlandt W. Lowered tissue-fluid oncotic pressure protects the blood volume in the nephrotic syndrome. Nephron. 1986;42:317–22.

    Article  CAS  PubMed  Google Scholar 

  13. Reimold EW, Marks JF. Hypovolemic shock complicating the nephrotic syndrome in children. J Pediatr. 1966;69:658–60.

    Article  CAS  PubMed  Google Scholar 

  14. Theuns-Valks SD, van Wijk JA, van Heerde M, Dolman KM, Bokenkamp A. Abdominal pain and vomiting in a boy with nephrotic syndrome. Clin Pediatr (Phila). 2011;50:470–3.

    Article  Google Scholar 

  15. Van de Walle JG, Donckerwolcke RA, Greidanus TB, Joles JA, Koomans HA. Renal sodium handling in children with nephrotic relapse: relation to hypovolaemic symptoms. Nephrol Dial Transplant. 1996;11:2202–8.

    Article  PubMed  Google Scholar 

  16. Wang SJ, Tsau YK, Lu FL, Chen CH. Hypovolemia and hypovolemic shock in children with nephrotic syndrome. Acta Paediatr Taiwan. 2000;41:179–83.

    CAS  PubMed  Google Scholar 

  17. Dorhout Mees EJ. Does it make sense to administer albumin to the patient with nephrotic oedema? Nephrol Dial Transplant. 1996;11:1224–6.

    Article  CAS  PubMed  Google Scholar 

  18. Dorhout Mees EJ, Koomans HA. Understanding the nephrotic syndrome: what’s new in a decade? Nephron. 1995;70:1–10.

    Article  CAS  PubMed  Google Scholar 

  19. Eisenberg S. Blood volume in persons with the nephrotic syndrome. Am J Med Sci. 1968;255:320–6.

    Article  CAS  PubMed  Google Scholar 

  20. Dorhout EJ, Roos JC, Boer P, Yoe OH, Simatupang TA. Observations on edema formation in the nephrotic syndrome in adults with minimal lesions. Am J Med. 1979;67:378–84.

    Article  CAS  PubMed  Google Scholar 

  21. Dorhout Mees EJ, Geers AB, Koomans HA. Blood volume and sodium retention in the nephrotic syndrome: a controversial pathophysiological concept. Nephron. 1984;36:201–11.

    Article  CAS  PubMed  Google Scholar 

  22. Fauchald P, Noddeland H, Norseth J. Interstitial fluid volume, plasma volume and colloid osmotic pressure in patients with nephrotic syndrome. Scand J Clin Lab Invest. 1984;44:661–7.

    Article  CAS  PubMed  Google Scholar 

  23. Fauchald P, Noddeland H, Norseth J. An evaluation of ultrafiltration as treatment of diuretic-resistant oedema in nephrotic syndrome. Acta Med Scand. 1985;217:127–31.

    Article  CAS  PubMed  Google Scholar 

  24. Geers AB, Koomans HA, Boer P, Dorhout Mees EJ. Plasma and blood volumes in patients with the nephrotic syndrome. Nephron. 1984;38:170–3.

    Article  CAS  PubMed  Google Scholar 

  25. Geers AB, Koomans HA, Roos JC, Dorhout Mees EJ. Preservation of blood volume during edema removal in nephrotic subjects. Kidney Int. 1985;28:652–7.

    Article  CAS  PubMed  Google Scholar 

  26. Koomans HA, Braam B, Geers AB, Roos JC, Dorhout Mees EJ. The importance of plasma protein for blood volume and blood pressure homeostasis. Kidney Int. 1986;30:730–5.

    Article  CAS  PubMed  Google Scholar 

  27. Koomans HA, Geers AB, vd Meiracker AH, Roos JC, Boer P, Dorhout Mees EJ. Effects of plasma volume expansion on renal salt handling in patients with the nephrotic syndrome. Am J Nephrol. 1984;4:227–34.

    Article  CAS  PubMed  Google Scholar 

  28. Meltzer JI, Keim HJ, Laragh JH, Sealey JE, Jan KM, Chien S. Nephrotic syndrome: vasoconstriction and hypervolemic types indicated by renin-sodium profiling. Ann Intern Med. 1979;91:688–96.

    Article  CAS  PubMed  Google Scholar 

  29. Brown EA, Markandu N, Sagnella GA, Jones BE, MacGregor GA. Sodium retention in nephrotic syndrome is due to an intrarenal defect: evidence from steroid-induced remission. Nephron. 1985;39:290–5.

    Article  CAS  PubMed  Google Scholar 

  30. Brown EA, Markandu ND, Roulston JE, Jones BE, Squires M, MacGregor GA. Is the renin-angiotensin-aldosterone system involved in the sodium retention in the nephrotic syndrome? Nephron. 1982;32:102–7.

    Article  CAS  PubMed  Google Scholar 

  31. Brown EA, Markandu ND, Sagnella GA, Squires M, Jones BE, MacGregor GA. Evidence that some mechanism other than the renin system causes sodium retention in nephrotic syndrome. Lancet. 1982;2:1237–40.

    Article  CAS  PubMed  Google Scholar 

  32. Fadnes HO, Pape JF, Sundsfjord JA. A study on oedema mechanism in nephrotic syndrome. Scand J Clin Lab Invest. 1986;46:533–8.

    Article  CAS  PubMed  Google Scholar 

  33. Geers AB, Koomans HA, Roos JC, Boer P, Dorhout Mees EJ. Functional relationships in the nephrotic syndrome. Kidney Int. 1984;26:324–30.

    Article  CAS  PubMed  Google Scholar 

  34. Hammond TG, Whitworth JA, Saines D, Thatcher R, Andrews J, Kincaid-Smith P. Renin-angiotensin-aldosterone system in nephrotic syndrome. Am J Kidney Dis. 1984;4:18–23.

    Article  CAS  PubMed  Google Scholar 

  35. Shapiro MD, Nicholls KM, Groves BM, Schrier RW. Role of glomerular filtration rate in the impaired sodium and water excretion of patients with the nephrotic syndrome. Am J Kidney Dis. 1986;8:81–7.

    Article  CAS  PubMed  Google Scholar 

  36. Usberti M, Federico S, Meccariello S, Cianciaruso B, Balletta M, Pecoraro C, Sacca L, Ungaro B, Pisanti N, Andreucci VE. Role of plasma vasopressin in the impairment of water excretion in nephrotic syndrome. Kidney Int. 1984;25:422–9.

    Article  CAS  PubMed  Google Scholar 

  37. Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL, Lechene CP, Brenner BM. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest. 1983;71:91–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Deschenes G, Doucet A. Collecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes. J Am Soc Nephrol. 2000;11:604–15.

    CAS  PubMed  Google Scholar 

  39. Feraille E, Vogt B, Rousselot M, Barlet-Bas C, Cheval L, Doucet A, Favre H. Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome. J Clin Invest. 1993;91:1295–300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Kim SW, de Seigneux S, Sassen MC, Lee J, Kim J, Knepper MA, Frokiaer J, Nielsen S. Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2006;290:F674–87.

    Article  CAS  PubMed  Google Scholar 

  41. Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney Int. 1978;13:159–65.

    Google Scholar 

  42. Habib R, Kleinknecht C. The primary nephrotic syndrome of childhood. Classification and clinicopathologic study of 406 cases. Pathol Annu. 1971;6:417–74.

    CAS  PubMed  Google Scholar 

  43. White RH, Glasgow EF, Mills RJ. Clinicopathological study of nephrotic syndrome in childhood. Lancet. 1970;1:1353–9.

    Article  CAS  PubMed  Google Scholar 

  44. Bohlin AB. Clinical course and renal function in minimal change nephrotic syndrome. Acta Paediatr Scand. 1984;73:631–6.

    Article  CAS  PubMed  Google Scholar 

  45. Hopper J Jr, Ryan P, Lee JC, Rosenau W. Lipoid nephrosis in 31 adult patients: renal biopsy study by light, electron, and fluorescence microscopy with experience in treatment. Medicine (Baltimore). 1970;49:321–41.

    Article  Google Scholar 

  46. Carrie BJ, Golbetz HV, Michaels AS, Myers BD. Creatinine: an inadequate filtration marker in glomerular diseases. Am J Med. 1980;69:177–82.

    Article  CAS  PubMed  Google Scholar 

  47. Gur A, Adefuin PY, Siegel NJ, Hayslett JP. A study of the renal handling of water in lipoid nephrosis. Pediatr Res. 1976;10:197–201.

    Article  CAS  PubMed  Google Scholar 

  48. Koomans HA, Boer WH, Dorhout Mees EJ. Renal function during recovery from minimal lesions nephrotic syndrome. Nephron. 1987;47:173–8.

    Article  CAS  PubMed  Google Scholar 

  49. Nolasco F, Cameron JS, Heywood EF, Hicks J, Ogg C, Williams DG. Adult-onset minimal change nephrotic syndrome: a long-term follow-up. Kidney Int. 1986;29:1215–23.

    Article  CAS  PubMed  Google Scholar 

  50. Lowenstein J, Schacht RG, Baldwin DS. Renal failure in minimal change nephrotic syndrome. Am J Med. 1981;70:227–33.

    Article  CAS  PubMed  Google Scholar 

  51. Cameron MA, Peri U, Rogers TE, Moe OW. Minimal change disease with acute renal failure: a case against the nephrosarca hypothesis. Nephrol Dial Transplant. 2004;19:2642–6.

    Article  PubMed  Google Scholar 

  52. Esparza AR, Kahn SI, Garella S, Abuelo JG. Spectrum of acute renal failure in nephrotic syndrome with minimal (or minor) glomerular lesions. Role of hemodynamic factors. Lab Investig. 1981;45:510–21.

    CAS  PubMed  Google Scholar 

  53. Koomans HA. Pathophysiology of acute renal failure in idiopatic nephrotic syndrome. Nephrol Dial Transplant. 2001;16:221–4.

    Article  CAS  PubMed  Google Scholar 

  54. Robson AM, Giangiacomo J, Kienstra RA, Naqvi ST, Ingelfinger JR. Normal glomerular permeability and its modification by minimal change nephrotic syndrmone. J Clin Invest. 1974;54:1190–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Bohman SO, Jaremko G, Bohlin AB, Berg U. Foot process fusion and glomerular filtration rate in minimal change nephrotic syndrome. Kidney Int. 1984;25:696–700.

    Article  CAS  PubMed  Google Scholar 

  56. Drumond MC, Kristal B, Myers BD, Deen WM. Structural basis for reduced glomerular filtration capacity in nephrotic humans. J Clin Invest. 1994;94:1187–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Maas RJ, Deegens JK, Wetzels JF. Permeability factors in idiopathic nephrotic syndrome: historical perspectives and lessons for the future. Nephrol Dial Transplant. 2014;29:2207–16.

    Article  CAS  PubMed  Google Scholar 

  58. Chamberlain MJ, Pringle A, Wrong OM. Oliguric renal failure in the nephrotic syndrome. Q J Med. 1966;35:215–35.

    CAS  PubMed  Google Scholar 

  59. Conolly ME, Wrong OM, Jones NF. Reversible renal failure in idiopathic nephrotic syndrome with minimal glomerular changes. Lancet. 1968;1:665–8.

    Article  CAS  PubMed  Google Scholar 

  60. Harats D, Friedlander M, Koplovic Y, Friedman G. Prolonged reversible acute renal failure in focal glomerulonephritis with severe nephrotic syndrome in an elderly patient. Klin Wochenschr. 1989;67:502–5.

    Article  CAS  PubMed  Google Scholar 

  61. Holdsworth DR, Stephenson P, Dowling JP, Atkins RC. Reversible acute renal failure in the nephrotic syndrome with minimal glomerular pathology. Med J Aust. 1977;2:532–3.

    CAS  PubMed  Google Scholar 

  62. Hulter HN, Bonner EL Jr. Lipoid nephrosis appearing as acute oliguric renal failure. Arch Intern Med. 1980;140:403–5.

    Article  CAS  PubMed  Google Scholar 

  63. Imbasciati E, Ponticelli C, Case N, Altieri P, Bolasco F, Mihatsch MJ, Zollinger HU. Acute renal failure in idiopathic nephrotic syndrome. Nephron. 1981;28:186–91.

    Article  CAS  PubMed  Google Scholar 

  64. Jennette JC, Falk RJ. Adult minimal change glomerulopathy with acute renal failure. Am J Kidney Dis. 1990;16:432–7.

    Article  CAS  PubMed  Google Scholar 

  65. Raij L, Keane WF, Leonard A, Shapiro FL. Irreversible acute renal failure in idiopathic nephrotic syndrome. Am J Med. 1976;61:207–14.

    Article  CAS  PubMed  Google Scholar 

  66. Scully RE, Galdabini JJ, McNeely BU. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17–1978. N Engl J Med. 1978;298:1014–21.

    Article  CAS  PubMed  Google Scholar 

  67. Searle M, Cooper C, Elliman J, Dathan R, Maciver A. Reversibility of acute renal failure in elderly patients with the nephrotic syndrome. Postgrad Med J. 1985;61:741–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Stephens VJ, Yates AP, Lechler RI, Baker LR. Reversible uraemia in normotensive nephrotic syndrome. Br Med J. 1979;2:705–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Smith JD, Hayslett JP. Reversible renal failure in the nephrotic syndrome. Am J Kidney Dis. 1992;19:201–13.

    Article  CAS  PubMed  Google Scholar 

  70. Mak SK, Short CD, Mallick NP. Long-term outcome of adult-onset minimal-change nephropathy. Nephrol Dial Transplant. 1996;11:2192–201.

    Article  CAS  PubMed  Google Scholar 

  71. Chen T, Lv Y, Lin F, Zhu J. Acute kidney injury in adult idiopathic nephrotic syndrome. Ren Fail. 2011;33:144–9.

    Article  PubMed  Google Scholar 

  72. Waldman M, Crew RJ, Valeri A, Busch J, Stokes B, Markowitz G, D’Agati V, Appel G. Adult minimal-change disease: clinical characteristics, treatment, and outcomes. Clin J Am Soc Nephrol. 2007;2:445–53.

    Article  CAS  PubMed  Google Scholar 

  73. Chen CL, Fang HC, Chou KJ, Lee JC, Lee PT, Chung HM, Wang JS. Increased endothelin 1 expression in adult-onset minimal change nephropathy with acute renal failure. Am J Kidney Dis. 2005;45:818–25.

    Article  CAS  PubMed  Google Scholar 

  74. Kilis-Pstrusinska K, Zwolinska D, Musial K. [Acute renal failure in children with idiopathic nephrotic syndrome]. Pol Merkur Lekarski. 2000;8:462–4.

    Google Scholar 

  75. Rheault MN, Zhang L, Selewski DT, Kallash M, Tran CL, Seamon M, Katsoufis C, Ashoor I, Hernandez J, Supe-Markovina K, D’Alessandri-Silva C, DeJesus-Gonzalez N, Vasylyeva TL, Formeck C, Woll C, Gbadegesin R, Geier P, Devarajan P, Carpenter SL, Kerlin BA, Smoyer WE, Midwest Pediatric Nephrology C. AKI in children hospitalized with nephrotic syndrome. Clin J Am Soc Nephrol. 2015;10:2110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Rheault MN, Wei CC, Hains DS, Wang W, Kerlin BA, Smoyer WE. Increasing frequency of acute kidney injury amongst children hospitalized with nephrotic syndrome. Pediatr Nephrol. 2014;29:139–47.

    Article  PubMed  Google Scholar 

  77. Agarwal N, Phadke KD, Garg I, Alexander P. Acute renal failure in children with idiopathic nephrotic syndrome. Pediatr Nephrol. 2003;18:1289–92.

    Article  PubMed  Google Scholar 

  78. Cavagnaro F, Lagomarsino E. Peritonitis as a risk factor of acute renal failure in nephrotic children. Pediatr Nephrol. 2000;15:248–51.

    Article  CAS  PubMed  Google Scholar 

  79. Sakarcan A, Timmons C, Seikaly MG. Reversible idiopathic acute renal failure in children with primary nephrotic syndrome. J Pediatr. 1994;125:723–7.

    Article  CAS  PubMed  Google Scholar 

  80. Vande Walle J, Mauel R, Raes A, Vandekerckhove K, Donckerwolcke R. ARF in children with minimal change nephrotic syndrome may be related to functional changes of the glomerular basal membrane. Am J Kidney Dis. 2004;43:399–404.

    Article  PubMed  Google Scholar 

  81. Hill GS. Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens. 2008;17:266–70.

    Article  PubMed  Google Scholar 

  82. Meyrier A. Nephrosclerosis: update on a centenarian. Nephrol Dial Transplant. 2014.

    Google Scholar 

  83. Meyrier A. Nephrosclerosis: a term in quest of a disease. Nephron. 2015;129:276–82.

    Article  CAS  PubMed  Google Scholar 

  84. Textor SC. Atherosclerotic renal artery stenosis: flaws in estimated glomerular filtration rate and the problem of progressive kidney injury. Circ Cardiovasc Interv. 2011;4:213–5.

    Article  PubMed  Google Scholar 

  85. Aspelin P, Aubry P, Fransson SG, Strasser R, Willenbrock R, Berg KJ, Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar, Low-Osmolar Non-Ionic Contrast Media Study Investigators. Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med. 2003;348:491–9.

    Article  CAS  PubMed  Google Scholar 

  86. Glassock RJ. Secondary minimal change disease. Nephrol Dial Transplant. 2003;18 Suppl 6:vi52–8.

    PubMed  Google Scholar 

  87. Brezin JH, Katz SM, Schwartz AB, Chinitz JL. Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1979;301:1271–3.

    Article  CAS  PubMed  Google Scholar 

  88. Curt GA, Kaldany A, Whitley LG, Crosson AW, Rolla A, Merino MJ, D’Elia JA. Reversible rapidly progressive renal failure with nephrotic syndrome due to fenoprofen calcium. Ann Intern Med. 1980;92:72–3.

    Article  CAS  PubMed  Google Scholar 

  89. Feinfeld DA, Olesnicky L, Pirani CL, Appel GB. Nephrotic syndrome associated with use of the nonsteroidal anti-inflammatory drugs. Case report and review of the literature. Nephron. 1984;37:174–9.

    Article  CAS  PubMed  Google Scholar 

  90. Kleinknecht C, Broyer M, Gubler MC, Palcoux JB. Irreversible renal failure after indomethacin in steroid-resistant nephrosis. N Engl J Med. 1980;302:691.

    CAS  PubMed  Google Scholar 

  91. Kleinknecht D. Interstitial nephritis, the nephrotic syndrome, and chronic renal failure secondary to nonsteroidal anti-inflammatory drugs. Semin Nephrol. 1995;15:228–35.

    CAS  PubMed  Google Scholar 

  92. Lomvardias S, Pinn VW, Wadhwa ML, Koshy KM, Heller M. Nephrotic syndrome associated with sulindac. N Engl J Med. 1981;304:424.

    CAS  PubMed  Google Scholar 

  93. Morgenstern SJ, Bruns FJ, Fraley DS, Kirsch M, Borochovitz D. Ibuprofen-associated lipoid nephrosis without interstitial nephritis. Am J Kidney Dis. 1989;14:50–2.

    Article  CAS  PubMed  Google Scholar 

  94. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984;310:563–72.

    Article  CAS  PubMed  Google Scholar 

  95. Lafrance JP, Miller DR. Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury. Pharmacoepidemiol Drug Saf. 2009;18:923–31.

    Article  CAS  PubMed  Google Scholar 

  96. Almansori M, Kovithavongs T, Qarni MU. Cyclooxygenase-2 inhibitor-associated minimal-change disease. Clin Nephrol. 2005;63:381–4.

    Article  CAS  PubMed  Google Scholar 

  97. Chen YH, Tarng DC. Profound urinary protein loss and acute renal failure caused by cyclooxygenase-2 inhibitor. Chin J Physiol. 2011;54:264–8.

    Article  PubMed  Google Scholar 

  98. Singhal R, Brimble KS. Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management. Thromb Res. 2006;118:397–407.

    Article  CAS  PubMed  Google Scholar 

  99. Llach F, Papper S, Massry SG. The clinical spectrum of renal vein thrombosis: acute and chronic. Am J Med. 1980;69:819–27.

    Article  CAS  PubMed  Google Scholar 

  100. Luyckx VA, Naicker S. Acute kidney injury associated with the use of traditional medicines. Nat Clin Pract Nephrol. 2008;4:664–71.

    Article  PubMed  Google Scholar 

Download references

Conflict of Interest Statement

The authors deny any conflict of interest with regard to this chapter.

Author information

Authors and Affiliations

  1. Service de Néphrologie, Hôpital Georges Pompidou, Université Paris-Descartes Medical School, Paris, France

    Alain Meyrier

  2. Department of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

Authors
  1. Alain Meyrier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Patrick Niaudet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Sushrut S. Waikar

  2. University College Dublin, Dublin, Ireland

    Patrick T. Murray

  3. Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Ajay K. Singh

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Science+Business Media, LLC, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Meyrier, A., Niaudet, P. (2018). Acute Kidney Failure and Minimal Change Disease. In: Waikar, S., Murray, P., Singh, A. (eds) Core Concepts in Acute Kidney Injury. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8628-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-8628-6_11

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-8626-2

  • Online ISBN: 978-1-4939-8628-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation