Recurrent Pregnancy Loss

  • Carolyn B. Coulam
  • Melissa J. Miller


Although many advances in reproductive medicine have been made during the past 25 years, miscarriages remain the most common complication of pregnancy. While most miscarriages are sporadic and not repetitive, there is a subset of couples that suffer recurrent miscarriage. In the past, the definition of recurrent pregnancy loss was considered to be three or more miscarriages. A short time ago, the American Society for Reproductive Medicine published a change of definition of recurrent pregnancy loss: “Recurrent pregnancy loss is a disease distinct from infertility, defined by 2 or more failed pregnancies”. Historically, the cause of recurrent pregnancy loss was unknown in most couples. More recently, however, much progress has been made in understanding the mechanisms involved. Two major reasons for recurrent pregnancy loss exist. One is that there is a problem with the pregnancy itself that prohibits the pregnancy from growing properly. The other reason is a problem within the uterine environment that does not allow an otherwise normal embryo to grow properly.


Recurrent pregnancy loss Uterine environment Anatomic Hormonal Immunologic Thrombophilic Treatment Miscarriage 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Reproductive Medicine InstituteEvanstonUSA
  2. 2.Advocate Sherman HospitalElginUSA

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