Abstract
In recent years there has been a significant advancement in the role of gut microbiota in regulating gastrointestinal motility. The bidirectional cross talk between the host and gut microbiota has been implicated in the regulation of both physiological and pathophysiological conditions. Intestinal dysbiosis or alteration in the composition of intestinal microbiota can result in impaired host intestinal permeability, immune response, and metabolism, leading to a proinflammatory state. In this review, we focus on the role of the gut microbiome in regulating gastrointestinal motility and shaping the enteric nervous system. We highlight the mechanisms of microbial metabolites in regulating intestinal motility. Several host factors such as diet and genetic predisposition can influence the gut microbial diversity and ultimately contribute to dysbiosis. Intestinal dysbiosis can contribute to the pathophysiology of disorders such as irritable bowel syndrome and chronic intestinal pseudo-obstruction. Manipulation of the gut microbiome is a promising therapeutic target for the treatment of motility disorders. Modification of gut microbiota through diet, antibiotics, probiotics, prebiotics, and fecal microbiota transplantation are all promising strategies for the treatment of gastrointestinal motility disorders that are currently under investigation.
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Aziz Q, Dore J, Emmanuel A, Guarner F, Quigley EM (2013) Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil 25(1):4–15
Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D et al (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126(3):693–702
Bearcroft CP, Perrett D, Farthing MJ (1996) 5-hydroxytryptamine release into human jejunum by cholera toxin. Gut 39(4):528–531
Brenner DM, Moeller MJ, Chey WD, Schoenfeld PS (2009) The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review. Am J Gastroenterol 104(4):1033–1049
Camilleri M (2015) Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver 9(3):332–339
Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A (2011) Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol 17(12):1519–1528
Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A et al (2002) Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 122(7):1778–1783
Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Soldan MM et al (2016) Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep 6:28484
Collins J, Borojevic R, Verdu EF, Huizinga JD, Ratcliffe EM (2014) Intestinal microbiota influence the early postnatal development of the enteric nervous system. Neurogastroenterol Motil 26(1):98–107
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107(33):14691–14696
De Giorgio R, Cogliandro RF, Barbara G, Corinaldesi R, Stanghellini V (2011) Chronic intestinal pseudo-obstruction: clinical features, diagnosis, and therapy. Gastroenterol Clin North Am 40(4):787–807
Dukowicz AC, Lacy BE, Levine GM (2007) Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (NY) 3(2):112–122
Esmaili A, Nazir SF, Borthakur A, Yu D, Turner JR, Saksena S et al (2009) Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology 137(6):2074–2083
Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA et al (2011) Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease. PLoS One 6(12):e28032
Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M et al (2003) Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 284(5):R1269–R1276
Gabbard SL, Lacy BE (2013) Chronic intestinal pseudo-obstruction. Nutr Clin Pract 28(3):307–316
Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS et al (2006) Metagenomic analysis of the human distal gut microbiome. Science 312(5778):1355–1359
Gu L, Ding C, Tian H, Yang B, Zhang X, Hua Y et al (2017) Serial frozen fecal microbiota transplantation in the treatment of chronic intestinal pseudo-obstruction: a preliminary study. J Neurogastroenterol Motil 23(2):289–297
Halvorson HA, Schlett CD, Riddle MS (2006) Postinfectious irritable bowel syndrome—a meta-analysis. Am J Gastroenterol 101(8):1894–1899
Hurst NR, Kendig DM, Murthy KS, Grider JR (2014) The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon. Neurogastroenterol Motil 26(11):1586–1596
Husebye E, Skar V, Hoverstad T, Iversen T, Melby K (1995) Abnormal intestinal motor patterns explain enteric colonization with gram-negative bacilli in late radiation enteropathy. Gastroenterology 109(4):1078–1089
Husebye E, Hellstrom PM, Sundler F, Chen J, Midtvedt T (2001) Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol 280(3):G368–G380
Jalanka-Tuovinen J, Salojarvi J, Salonen A, Immonen O, Garsed K, Kelly FM et al (2014) Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut 63(11):1737–1745
Kelly CP, LaMont JT (2008) Clostridium difficile—more difficult than ever. N Engl J Med 359(18):1932–1940
Levy M, Thaiss CA, Zeevi D, Dohnalova L, Zilberman-Schapira G, Mahdi JA et al (2015) Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163(6):1428–1443
Levy M, Blacher E, Elinav E (2017) Microbiome, metabolites and host immunity. Curr Opin Microbiol 35:8–15
Ley RE (2010) Obesity and the human microbiome. Curr Opin Gastroenterol 26(1):5–11
Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124(4):837–848
Liebregts T, Adam B, Bredack C, Roth A, Heinzel S, Lester S et al (2007) Immune activation in patients with irritable bowel syndrome. Gastroenterology 132(3):913–920
Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J et al (2017) Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder. Cell Mol Gastroenterol Hepatol 3(2):218–230
Mackie RI, Sghir A, Gaskins HR (1999) Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 69(5):1035S–1045S
Marsh A, Eslick EM, Eslick GD (2016) Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis. Eur J Nutr 55(3):897–906
McVey Neufeld KA, Mao YK, Bienenstock J, Foster JA, Kunze WA (2013) The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterol Motil 25(2):183–e88
Medani M, Collins D, Docherty NG, Baird AW, O’Connell PR, Winter DC (2011) Emerging role of hydrogen sulfide in colonic physiology and pathophysiology. Inflamm Bowel Dis 17(7):1620–1625
Miazga A, Osinski M, Cichy W, Zaba R (2015) Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO. Adv Med Sci 60(1):118–124
Mizuno S, Masaoka T, Naganuma M, Kishimoto T, Kitazawa M, Kurokawa S et al (2017) Bifidobacterium-rich fecal donor may be a positive predictor for successful fecal microbiota transplantation in patients with irritable bowel syndrome. Digestion 96(1):29–38
Pimentel M, Lin HC, Enayati P, van den Burg B, Lee HR, Chen JH et al (2006) Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. Am J Physiol Gastrointest Liver Physiol 290(6):G1089–G1095
Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J et al (2011) Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 364(1):22–32
Pimentel M, Mathur R, Chang C (2013) Gas and the microbiome. Curr Gastroenterol Rep 15(12):356
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C et al (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285):59–65
Quigley EM (2011) Microflora modulation of motility. J Neurogastroenterol Motil 17(2):140–147
Quigley EM, Quera R (2006) Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics. Gastroenterology 130(2 Suppl 1):S78–S90
Rajilic-Stojanovic M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S et al (2011) Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141(5):1792–1801
Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118(2):229–241
Ratuapli SK, Ellington TG, O’Neill MT, Umar SB, Harris LA, Foxx-Orenstein AE et al (2012) Proton pump inhibitor therapy use does not predispose to small intestinal bacterial overgrowth. Am J Gastroenterol 107(5):730–735
Ringel Y (2017) The gut microbiome in irritable bowel syndrome and other functional bowel disorders. Gastroenterol Clin North Am 46(1):91–101
Roland BC, Ciarleglio MM, Clarke JO, Semler JR, Tomakin E, Mullin GE et al (2015) Small intestinal transit time is delayed in small intestinal bacterial overgrowth. J Clin Gastroenterol 49(7):571–576
Rossen NG, MacDonald JK, de Vries EM, D’Haens GR, de Vos WM, Zoetendal EG et al (2015) Fecal microbiota transplantation as novel therapy in gastroenterology: a systematic review. World J Gastroenterol 21(17):5359–5371
Rowland IR (2009) The role of the gastrointestinal microbiota in colorectal cancer. Curr Pharm Des 15(13):1524–1527
Saito YA, Schoenfeld P, Locke GR 3rd (2002) The epidemiology of irritable bowel syndrome in North America: a systematic review. Am J Gastroenterol 97(8):1910–1915
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE et al (2016) Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 167(6):1469–1480.e12
Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E et al (2015) Gut microbiota are related to Parkinson’s disease and clinical phenotype. Mov Disord 30(3):350–358
Sekirov I, Russell SL, Antunes LC, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90(3):859–904
Shen L, Liu L, Ji HF (2017) Alzheimer’s disease histological and behavioral manifestations in transgenic mice correlate with specific gut microbiome state. J Alzheimers Dis 56(1):385–390
Sikander A, Rana SV, Prasad KK (2009) Role of serotonin in gastrointestinal motility and irritable bowel syndrome. Clin Chim Acta 403(1–2):47–55
Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP et al (2010) Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology 138(5):1772–1782
Stotzer PO, Bjornsson ES, Abrahamsson H (1996) Interdigestive and postprandial motility in small-intestinal bacterial overgrowth. Scand J Gastroenterol 31(9):875–880
Thabane M, Kottachchi DT, Marshall JK (2007) Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment Pharmacol Ther 26(4):535–544
Tian H, Ge X, Nie Y, Yang L, Ding C, McFarland LV et al (2017) Fecal microbiota transplantation in patients with slow-transit constipation: a randomized, clinical trial. PLoS One 12(2):e0171308
Tornblom H, Lindberg G, Nyberg B, Veress B (2002) Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 123(6):1972–1979
Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Burmann J et al (2016) Short chain fatty acids and gut microbiota differ between patients with Parkinson’s disease and age-matched controls. Parkinsonism Relat Disord 32:66–72
Vantrappen G, Janssens J, Hellemans J, Ghoos Y (1977) The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59(6):1158–1166
Villarreal AA, Aberger FJ, Benrud R, Gundrum JD (2012) Use of broad-spectrum antibiotics and the development of irritable bowel syndrome. WMJ 111(1):17–20
Whelan K (2011) Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and systematic reviews. Curr Opin Clin Nutr Metab Care 14(6):581–587
Wu S, Yi J, Zhang YG, Zhou J, Sun J (2015) Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. Physiol Rep 3(4) pii: e12356
Zhang YG, Wu S, Yi J, Xia Y, Jin D, Zhou J et al (2017) Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis. Clin Ther 39(2):322–336
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Raja, S., Batra, V., Srinivasan, S. (2018). The Influence of Microbiota on Gastrointestinal Motility. In: Sun, J., Dudeja, P. (eds) Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. Physiology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4939-7534-1_6
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DOI: https://doi.org/10.1007/978-1-4939-7534-1_6
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