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The Rise of Fetal and Neonatal Physiology pp 821–842Cite as

Epilogue

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Part of the book series: Perspectives in Physiology ((PHYSIOL))

Abstract

As noted in the introduction, the Oxford chemist and Nobel Laureate Sir Cyril Hinshelwood defined science as “… an imaginative adventure of the mind seeking truth in a world of mystery” (Hinshelwood 1954, p. 301). In the lines quoted above, he cautioned that the search is not without its challenges. Science constitutes a boundless and persistent quest for knowledge and wisdom. Unique among fields of mental enterprise, the process requires curiosity, creativity, and dedicated work and is characterized by communalism, universalism, disinterestedness, originality, and skepticism. Science possesses an informal quality assurance system of peer review, publication, and independent replication. As noted earlier, this essay might be viewed as a case study in the manner in which a special field of biomedical science has emerged and continues to evolve, and the way in which individuals, their ideas, and social forces critically interact in that development. As with much of contemporary biomedical science, fetal and neonatal physiology is based in general on the “Galilean-Harveian” hypothetico-deductive method, with the careful analysis of observed phenomena, generation of a testable hypothesis, designing and recording of experiments to test these hypotheses, and the further wholesale collection of observations and data to explore a more refined hypothesis. These are generated in sufficient detail to extend beyond mere empirical observation and allow the innovation of quantitative reasoning to establish a proposed general principle and to enable reproducibility.

If we are to vindicate the claim to be seeking the nature of things, then it must be extensive. The broad picture must be sought, outworn detail discarded, and all help possible derived from simplifications and generalizations…. This is no doubt more easily said than done, but 1whoever believed that our task is an easy one? Nor is our responsibility lessened by the need … of guarding against the superficial and the inaccurate, of deriving full benefit from the intensive approach and from special disciplines, and of combining the survey of the small-scale map with the detailed scrutiny of the large-scale insets.

(Sir Cyril Hinshelwood 1954, p. 307)

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Notes

  1. 1.

    I Corinthians 13:12, King James Version.

References

  • Atkinson, J.W. Models and myths of science: views of the elephant. Am Zool 25:727-736, 1985.

    Article  Google Scholar 

  • Bacon, F. Novum organum Scientiarum. Londini, 1620a.

    Google Scholar 

  • Bacon, F. Francisci de Verulamio Instauratio magna multi pertransibunt & augebitur scientia. Londini, Apud Joannem Billium, Typographum Regium, 1620b.

    Google Scholar 

  • Bacon, F. Francisci Baronis de Verulamio, Vice-Comitis Sancti Albani, De dignitate & augmentis scientiarum libri IX. Londini, In officina Ioannis Hauiland, 1623.

    Google Scholar 

  • Bayes, T. An essay towards solving a problem in the doctrine of chances.. Phil Trans 53:370-418, 1763. (Reprinted in Biometrika 45:296-315, 1958).

    Google Scholar 

  • Bernard, C. Introduction à l’etude de la médecine experémentale. Paris, Baillière, 1865.

    Google Scholar 

  • Brecht, B. Leben des Galilei: Schauspiel. Berlin, Suhrkamp Verlag, 1938-1939.

    Google Scholar 

  • Cadman, E.C. The academic physician-investigator: a crisis not to be ignored. Ann Intern Med 120:401-410, 1994.

    Article  CAS  PubMed  Google Scholar 

  • Calder, R. Profile of science. London, George Allen & Unwin, 1951.

    Google Scholar 

  • Carson, R. Silent spring. Greenwich, CT., Fawcett, 1962.

    Google Scholar 

  • Chamberlin, T.C. The method of multiple working hypotheses: With this method the dangers of parental affection for a favorite theory can be circumvented. Science 148:754-759, 1965.

    Article  CAS  PubMed  Google Scholar 

  • Comroe, J.H., Jr. Retrospectroscope. Speculation on speculation. Am Rev Respir Dis 115:343-349, 1977.

    PubMed  Google Scholar 

  • Comroe, J.H., Jr. & R.D. Dripps. Ben Franklin and open heart surgery. Circ Res 35:661-669, 1974.

    Article  PubMed  Google Scholar 

  • Comroe, J.H., Jr. & R.D. Dripps. Scientific basis for the support of biomedical science. Science 192:105-111, 1976.

    Article  PubMed  Google Scholar 

  • Davis, R.H. Strong inference: rationale or inspiration? Perspect Biol Med 49:238-249, 2006.

    Article  PubMed  Google Scholar 

  • Dawes, G.S. Perinatal physiology, the past, present and future. In: The physiological development of the fetus and newborn. C.T. Jones & P.W. Nathanielsz (Eds). London, Academic Press, 1985, pp. 827-830.

    Google Scholar 

  • Eliot, T.S. The Rock. In: Collected poems 1909-1962. New York, Harcourt Brace & World, Inc., 1963.

    Google Scholar 

  • Feinstein, A.R. Clinical biostatistics. XXXIX. The haze of Bayes, the aerial palaces of decision analysis, and the computerized Ouija board. Clin Pharmacol Ther 21:482-496, 1977.

    Article  CAS  PubMed  Google Scholar 

  • Franklin, K.J. Joseph Barcroft 1872-1947. Oxford, Oxford University Press, 1953.

    Google Scholar 

  • Goldstein, J.L. & M.S. Brown. The clinical investigator: bewitched, bothered, and bewildered – but still beloved. J Clin Invest 99:2803-2812, 1997.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hiebert, S.M. The strong-inference protocol: not just for grant proposals. Adv Physiol Educ 31:93-96, 2007.

    Article  PubMed  Google Scholar 

  • Hinshelwood, Sir C. Thoughts on the evolution of a scientific problem. Sch Sci Rev 35:300-308, 1954.

    Google Scholar 

  • Hinshelwood, Sir C. Address of the President …, at the Formal Opening Ceremony of the Tercentenary Celebrations at the Royal Albert Hall, 19 July 1960. Proc R Soc Lond A 257:421-430, 1960.

    Article  Google Scholar 

  • Howson, C. & P. Urbach. Scientific reasoning: the Bayesian approach. Chicago, Open Court Publishing, 2005.

    Google Scholar 

  • Jensen, F.V. An introduction to Bayesian networks. New York, Springer-Verlag, 1996.

    Google Scholar 

  • Kinraide, T.B. & R.F. Denison. Strong inference: the way of science. Am Biol Teacher 65:419-424, 2003.

    Article  Google Scholar 

  • Krebs, H.A. The making of a scientist. Nature 215:1441-1445, 1967.

    Article  CAS  PubMed  Google Scholar 

  • Kretchmer, N. On the homology between human development and pediatrics. Pediatr Res 2:283-286, 1968.

    Article  CAS  PubMed  Google Scholar 

  • Kretchmer, N. Prospectives in pediatric research. Pediatr Res 11:992-993, 1977.

    CAS  PubMed  Google Scholar 

  • Kretchmer, N. & E.G. Hasselmeyer. Horizons in perinatal research. Implications for clinical care. New York, John Wiley & Sons, 1974.

    Google Scholar 

  • Kuhn, T.S. The structure of scientific revolutions. Chicago, IL, University of Chicago Press, 1962. (Fourth edition, 2012).

    Google Scholar 

  • Lipton, P. Testing hypotheses: prediction and prejudice. Science 307:219-221, 2005.

    Article  CAS  PubMed  Google Scholar 

  • Longo, L.D. & R.B. Jaffe. A challenge for the twenty-first century: whither physician scientists in obstetrics and gynecology and the reproductive sciences? Am J Obstet Gynecol 198: 489-495, 2008.

    Article  PubMed  Google Scholar 

  • Longo, L.D., M.E. McClure & R.B. Jaffe. Reproductive physician-scientists for the twenty-first century. Am J Obstet Gynecol 181:934-939, 1999.

    Article  CAS  PubMed  Google Scholar 

  • Macklem, P.T. Emergent phenomena and the secrets of life. J Appl Physiol 104:1844-1846, 2008.

    Article  PubMed  Google Scholar 

  • Mandelbrot, B.B. Fractals: form, chance, and dimension. San Francisco, W.H. Freeman, 1977.

    Google Scholar 

  • Mandelbrot, B.B. The fractal geometry of nature. San Francisco, W.H. Freeman, 1982.

    Google Scholar 

  • Medawar, P.B. Induction and intuition in scientific thought. Jayne Lectures for 1968. Philadelphia, American Philosophical Society, 1969.

    Google Scholar 

  • Merton, R.K. On the shoulders of giants. A Shandean Postscript. With a Foreword by C.D. Bowen. New York, The Free Press, 1965.

    Google Scholar 

  • Nabel, G.J. The coordinates of truth. Science 326:53-54, 2009.

    Article  CAS  PubMed  Google Scholar 

  • Neilson, E.G., D. Ausiello & L.L. Demer. Physician-scientists as missing persons. J Investig Med 43:534-542, 1995.

    CAS  PubMed  Google Scholar 

  • Perutz, M.F. Fundamental research in molecular biology: relevance to medicine. Nature 262:449-453, 1976.

    Article  CAS  PubMed  Google Scholar 

  • Platt, J.R. Strong inference. Certain systematic methods of scientific thinking may produce much more rapid progress than others. Science 146:347-353, 1964.

    Article  CAS  PubMed  Google Scholar 

  • Poincaré, H. Reflections. Mathematical creation. Resonance 5:85-94, 2000.

    Article  Google Scholar 

  • Polanyi, M. Science, faith and society. London, Oxford University Press, 1946.

    Google Scholar 

  • Polanyi, M. Personal knowledge: towards a post-critical philosophy. Chicago, University of Chicago Press, 1958.

    Google Scholar 

  • Polanyi, M. The tacit dimension. Garden City, NY, Doubleday, 1966.

    Google Scholar 

  • Popper, K.R. The logic of scientific discovery. New York, Basic Books, Inc., 1959.

    Google Scholar 

  • Popper, K.R. All life is problem solving. London, Routledge, 1999.

    Google Scholar 

  • Reynolds, S.R.M. Many slender threads: an essay on progress in perinatal research. In: Fetal and newborn cardiovascular physiology. Vol 1. L.D. Longo & D.D. Reneau (Eds). New York, Garland STPM Press, 1978, pp. 33-45.

    Google Scholar 

  • Rosenberg, L. Physician-scientists – endangered and essential. Science 283:331-332, 1999.

    Article  CAS  PubMed  Google Scholar 

  • Sannazaro, Jacopo. Arcadia … Tutta Fornita Et Tratta Emendatissima Dal Suo Originale. Sigismundo Mayr: Napoli, 1504. Print.

    Google Scholar 

  • Schechter, A.N. The crisis in clinical research: endangering the half-century National Institutes of Health Consensus. JAMA 280:1440-1442, 1998.

    Article  CAS  PubMed  Google Scholar 

  • Szent-Györgyi, A. Looking back. Perspect Biol Med 15:1-5, 1971.

    Article  PubMed  Google Scholar 

  • Szent-Györgyi, A. Research grants. Perspect Biol Med 18:41-43, 1974.

    Article  PubMed  Google Scholar 

  • Theocharis, T. & M. Psimopoulos. Where science has gone wrong. Nature 329:595-598, 1987.

    Article  Google Scholar 

  • Thomas, L. On the science and technology of medicine. Daedalus 106:35-46, 1977. Reprinted 117:299-316, 1988.

    Google Scholar 

  • Thornton, S. Karl Popper. In: The Stanford Encyclopedia of Philosophy (Winter 2011 Edition). E.N. Zalta (Ed). (http://plato.stanford.edu/archives/win2011/entries/popper/)

  • Walton, I. The compleat angler, 1653-1676. J. Bevan (Ed). Oxford, Clarendon Press, 1983.

    Book  Google Scholar 

  • Weimer, W.B. Notes on the methodology of scientific research. Hillsdale, N.J., Lawrence Erlbaum Associates, Publishers, 1979.

    Google Scholar 

  • Wenner, A.M. Concept-centered versus organism-centered biology. Am Zool 29:1177-1197, 1989.

    Article  Google Scholar 

  • Weyl, H. David Hilbert 1862-1943. Obit Not Fell R Soc 4:547-553, 1944.

    Article  Google Scholar 

  • Whewell, W. History of the inductive sciences: from the earliest to the present times. London, John W. Parker, 1837.

    Google Scholar 

  • Wyngaarden, J.B. The clinical investigator as an endangered species. N Engl J Med 301:1254-1259, 1979.

    Article  CAS  PubMed  Google Scholar 

  • Wyngaarden, J.B. Directions and challenges in health sciences research. Environ Health Perspect 52:271-275, 1983.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wyngaarden, J.B. Nurturing the scientific enterprise. J Med Educ 59:155-161, 1984.

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Lawrence D. Longo

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  1. Lawrence D. Longo
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Longo, L.D. (2018). Epilogue. In: The Rise of Fetal and Neonatal Physiology . Perspectives in Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7483-2_29

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