Metastatic Tumors in the Bone Marrow

  • Mohammad VasefEmail author
Part of the Atlas of Anatomic Pathology book series (AAP)


The vast majority of the non-hematolymphoid neoplasms in the bone marrow are metastatic in nature (Figs. 18.1, 18.2, 18.3, 18.4, 18.5, 18.6, 18.7, 18.8, 18.9, 18.10, 18.11, 18.12, 18.13, 18.14, 18.15, 18.16, 18.17, 18.18, 18.19, 18.20, 18.21, 18.22, 18.23, 18.24, 18.25, 18.26, 18.27, 18.28, 18.29, 18.30, 18.31, 18.32, 18.33, 18.34, 18.35, 18.36, 18.37, and 18.38). Accurate diagnosis and subtyping require careful histomorphologic examination with integration of immunohistochemical results and, in certain cases, cytogenetics and molecular genetic findings.


Metastasis Breast carcinoma Prostate carcinoma Lung carcinoma Neuroblastoma Rhabdomyosarcoma Retinoblastoma Primitive neuroectodermal tumor PNET Ewing sarcoma 

Suggested Reading

  1. 1.
    Chabot-Richards D, Buehler K, Vasef MA. Detection of EGFR exon 19 E746-A750 deletion and EGFR exon21 point mutations in lung adenocarcinoma by Immunohistochemistry: a comparative study to EGFR exons 19 and 21 mutations analysis using PCR followed by high-resolution melting and pyrosequencing. J Histotechnology. 2015;38:56–62.CrossRefGoogle Scholar
  2. 2.
    Cotta CV, Konoplev S, Medeiros LJ, Bueso-Ramos CE. Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment. Ann Diagn Pathol. 2006;10:169–92.CrossRefPubMedGoogle Scholar
  3. 3.
    Grzywacs B. Metastatic tumors involving bone marrow. In: Foucar K, McKenna RW, Peterson LC, Kroft SH, editors. Tumors of the bone marrow. AFIP Atlas of Tumor Pathology Series, vol. 4. Washington, DC: American Registry of Pathology; 2016. p. 787–805.Google Scholar
  4. 4.
    Russell HV, Golding LA, Suell MN, Nuchtern JG, Strother DR. The role of bone marrow evaluation in the staging of the patients with otherwise localized, low-risk neuroblastoma. Pediatr Blood Cancer. 2005;45:916–9.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA

Personalised recommendations