Abstract
Mental disorders are the greatest source of medical and occupational morbidity among active-duty US military service members. Psychotic disorders, in particular schizophrenia and schizoaffective disorder, are among the most severe mental disorders and account for a substantial portion of hospitalizations and medical retirements. Service members who are medically retired due to schizophrenia or a related disorder generally have their care transferred to the Department of Veterans Affairs (VA), where comprehensive evidence-based treatment services are available that can effectively address all stages of the illness. This chapter focuses on schizophrenia because the evidence base for its clinical management is the best developed, but the principles of and strategies for treating schizophrenia are broadly applicable to related disorders, including schizoaffective disorder. Each illness stage—acute episode (initial and stabilization phases), maintenance and relapse prevention, and recovery—is discussed in detail, together with its unique challenges and treatment goals. Common comorbid conditions that can complicate the recognition and treatment of schizophrenia and related disorders—for example, post-traumatic stress disorder—also are considered. Finally, VA and non-VA systems of care are compared to provide a broader context for the discussion.
Notes
- 1.
It is interesting to note that the apparent drop in schizophrenia incidence among navy personnel followed the publication of DSM-III in 1980; this edition was the first in the series to provide objectively verifiable standardized diagnostic criteria for schizophrenia, which effectively narrowed its clinical definition (Tsuang and Tohen 2002).
- 2.
The customary practice is to hospitalize an actively psychotic service member promptly, and when clinically stable enough to be treated as an outpatient, transfer him/her to a medical holding company, where the service member will await the outcome of disability and physical evaluation board reviews. This process, which may take up to 1 year, determines whether the service member will be medically retired from military service.
- 3.
Prevalence measures the proportion of individuals who manifest a disorder at a specified time point, or during a specified time span. Point prevalence is the fraction of individuals at risk for a disorder who actually manifest that disorder at a narrow point in time (e.g., one or more days), whereas period prevalence references a longer time frame (e.g., 1 year). Lifetime prevalence is the fraction of individuals at risk for a disorder who manifest that disorder ever, who are alive on a given day. Lifetime morbid risk estimates the probability that a person will develop the disorder during a specified period in their life, or up to a particular age (Saha et al. 2005).
- 4.
Service members can access several mental health treatment options before entering psychiatric treatment. These are (a) the chaplain, who is also a trained counselor attuned to military lifestyle issues and able to offer confidential, professional assistance, and referral services; (b) combat stress control teams, which are a field resource capable of supporting the mental and emotional well-being of service members during deployments; and (c) nonmedical programs (Military One Source and Military and Family Life Counseling) whose counselors possess a masters or doctorate degree in a mental health field, are licensed or certified to practice independently and provide confidential, short-term counseling to active-duty, National Guard, and reserve service members (regardless of their activation status), and their families. These sessions are available in three formats: face to face, by telephone, or online in a secure real-time “chat” format. In addition, the Family Advocacy Program is a supportive resource for service members and their families that assesses, refers, and provides counseling for families experiencing domestic violence or child abuse. If FAP identifies someone as suicidal, they refer the individual to an MTF (a military treatment facility), TRICARE, or local community resource for immediate professional, medical, mental health treatment (http://www.militaryonesource.mil/casualty?content_id=268934).
- 5.
This authority is conferred by DoD Instruction 6490.04, “Mental Health Evaluations of Members of the Military Services” (March 4, 2013) (http://www.dtic.mil/whs/directives/corres/pdf/649004p.pdf), which incorporates and cancels the prior DoD Directive 6940.1, “Mental Health Evaluations of Members of the Armed Forces” (October 1, 1997) (http://biotech.law.lsu.edu/blaw/dodd/corres/pdf2/d64901p.pdf).
- 6.
As of September 18, 2016, there are no current VHA treatment guidelines for schizophrenia or schizoaffective disorder (http://www.healthquality.va.gov/). According to the VA/DoD Clinical Practice Guideline for Management of Bipolar Disorder in Adults (version 2.0, May 2010), the original VHA Clinical Practice Guideline for the Management of Persons with Psychosis, published in 2001, “was aimed to assist medical care providers in all aspects of mental health care for a cluster of medical conditions characterized as mood disorders” (p i).
- 7.
Serious mental illness (SMI) is defined by VA as a mental, behavioral, or emotional disorder that meets Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria (excluding cognitive and developmental disorders and disorders due to a general medical condition) and meets all of the following criteria: (1) Single unremitting episode of symptoms or with frequently recurring and/or prolonged episodes of symptoms; (2) Symptoms result in impairments in mood, thinking, family or other interpersonal relationships, behavior (often resulting in socio-legal consequences), and/or self-care which substantially interfere with or limit major life activities; and (3) The impact of these symptoms results in a functional impairment equivalent to a Global Assessment of Functioning (GAF) score of 50 or below (VHA Handbook 1163.06, January 7, 2016, p. 3).
References
Ahmed AO, Doane NJ, Mabe PA, Buckley PF, Birgenheir D, Goodrum NM (2012) Peers and peer-led interventions for people with schizophrenia. Psychiatr Clin N Am 35:699–715
Ahmed AO, Marino BA, Rosenthal E, Buckner A, Hunter KM, Mabe PA, Buckley PF (2016) Recovery in schizophrenia: what consumers know and do not know. Psychiatr Clin N Am 39:313–330
Aleman A, Kahn RS, Selten J-P (2003) Sex differences in the risk of schizophrenia: evidence from meta-analysis. Arch Gen Psychiatry 60:656–571
Allen MH, Currier GW, Hughes DH, Docherty JP, Carpenter D, Ross R (2003) Treatment of behavioral emergencies: a summary of the expert consensus guidelines. J Psychiatr Pract 9:16–38
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5), 5th edn. American Psychiatric Publishing, Washington, DC
American Psychiatric Association, Steering Committee on Practice Guidelines (2004) Practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry 161(suppl 2):1–56
Anketell C, Dorahy MJ, Shannon M, Elder R, Hamilton G, Corry M, MacSherry A, Curran D, O’Rawe B (2010) An exploratory analysis of voice hearing in chronic PTSD: potential associated mechanisms. J Trauma Dissoc 11:93–107
Barnes TRE and the Schizophrenia Consensus Group of the British Association for Psychopharmacology (2011) Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 25:567–620
Bauer MS, Lee A, Miller CJ, Bajor L, Li M, Penfold RB (2015) Effects of diagnostic inclusion criteria on prevalence and population characteristics in database research. Psychiatr Serv 66:141–148
Bellack AS (2006) Scientific and consumer models of recovery in schizophrenia: concordance, contrasts, and implications. Schizophr Bull 32:432–442
Blow FC, Zeber JE, McCarthy JF, Valenstein M, Gillon L, Bingham CR (2004) Ethnicity and diagnostic patterns in veterans with psychoses. Soc Psychiatry Psychiatr Epidemiol 39:841–851
Bobo WV, Hoge CW, Messina MA, Pavlovcic F, Levandowski D, Grieger T (2004) Characteristics of repeat users of an inpatient psychiatry service at a large military tertiary care hospital. Mil Med 169:648–653
Bowersox NW, Kilbourne AM, Abraham KM, Reck BH, Lai Z, Bohnert ASB, Goodrich DE, Davis CL (2012) Cause-specific mortality among Veterans with serious mental illness lost to follow-up. Gen Hosp Psychiatry 34:651–653
Braakman MH, Kortmann FAM, van den Brink W (2009) Validity of ‘post-traumatic stress disorder with secondary psychotic features’: a review of the evidence. Acta Psychiatr Scand 119:15–24
Brewin CR, Patel T (2010) Auditory pseudohallucinations in United Kingdom war veterans and civilians with posttraumatic stress disorder. J Clin Psychiatry 71:419–425
Brissos S, Veguilla MR, Taylor D, Balanzá-Martinez V (2014) The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Ther Adv Psychopharmacol 4:198–219
Buchanan RW, Kreyenbuhl J, Kelly DL, Noel JM, Boggs DL, Fischer BA, Himelhoch S, Fang B, Peterson E, Aquino PR, Keller W (2010) The 2009 Schizophrenia PORT psychopharmacological treatment recommendations and summary statements. Schizophr Bull 36:71–93
Buckley PF, Schooler NR, Goff DC, Kopelowicz A, Lauriello J, Manschreck TC, Mendelowitz A, Miller DD, Wilson DR, Ames D, Bustillo JR, Kane JM, Looney SW (2016) Comparison of injectable and oral antipsychotics in relapse rates in a pragmatic 30-month Schizophrenia Relapse Prevention Study. Psychiatr Serv Adv. https://doi.org/10.1176/appi.ps.201500466
Carpenter WT Jr (2016) The RDoC controversy: alternate paradigm or dominant paradigm? Am J Psychiatry 173:562–563
Chien WT, Yip ALK (2013) Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments. Neuropsychiat Dis Treat 9:1311–1332
Christian R, Saavedra L, Gaynes BN, Sheitman B, Wines RCM, Jonas DE, Viswanathan M, Ellis AR, Woodell C, Carey TS (2012) Future research needs for first- and second-generation antipsychotics for children and young adults. Future Research Needs Paper No. 13. (Prepared by the RTI-UNC Evidence-based Practice Center under Contract No. 290 2007 10056 I.) Rockville: Agency for Healthcare Research and Quality; Feb 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm
Chwastiak LA, Rosenheck RA, Desai R, Kasis LE (2010) The association of psychiatric illness and all-cause mortality in the national Department of Veterans Affairs health care system. Psychosom Med 72:817–822
Clark NG (2004) Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care 27:596–601
Coleman KJ, Stewart C, Waitzfelder BE, Zeber JE, Morales LS, Ahmed AT et al (2016) Racial-ethnic differences in psychiatric diagnoses and treatment across 11 health care systems in the mental health research network. Psychiatr Serv 67:749–757
College of Psychiatric and Neurologic Pharmacists (CPNP) (2016) https://cpnp.org/about/public/faq. Accessed 8/12/16
Cone SM, Brown MC, Stambaugh RL (2008) Characteristics of ambulatory care clinics and pharmacists in veterans affairs medical centers: an update. Am J Health Syst Pharm 65:631–635
Correll CU, Gallego JA (2012) Antipsychotic polypharmacy: a comprehensive evaluation of relevant correlates of a long-standing clinical practice. Psychiatr Clin North Am 35:661–681
Cowan DN, Weber NS, Fisher JA, Bedno SA, Niebuhr DW (2011) Incidence of adult onset schizophrenic disorders in the US military: patterns by sex, race and age. Schizophr Res 127:235–240
Crilly J (2007) The history of clozapine and its emergence in the U.S. market: a review and analysis. Hist Psychiatry 18:39–60
Davidson L, Chinman M, Sells D, Rowe M (2006a) Peer support among adults with serious mental illness: a report from the field. Schizophr Bull 32:443–450
Davidson L, Tondora J, Staeheli M, O’Connell M, Frey J, Chinman M (2006b) Recovery guides: an emerging model of community-based care for adults with psychiatric disabilities. In: Lightburn A, Sessions P (eds) Handbook of community-based clinical practice. Oxford University Press, London, pp 476–501. chapter 30
Davies LM, Drummond MF (1993) Assessment of costs and benefits of drug therapy for treatment-resistant schizophrenia in the United Kingdom. Br J Psychiatry 162:38–42
Davis CL, Kilbourne AM, Blow FC, Pierce JR, Winkel BM, Huycke E, Langberg R, Lyle D, Phillips Y, Visnic S (2012) Reduced mortality among Department of Veterans Affairs patients with schizophrenia or bipolar disorder lost to follow-up and engaged in active outreach to return for care. Am J Public Health 102:S74–S79
De Fazio P, Gaetano R, Caroleo M, Cerminara G, Maida F, Bruno A, Muscatello MR, Moreno MJJ, Russo E, Segura-García C (2015) Rare and very rare adverse effects of clozapine. Neuropsychiatr Dis Treat 11:1995–2003
de Leon J, Odom-White A, Josiassen RC, Diaz FJ, Cooper TB, Simpson GM (2003) Serum antimuscarinic activity during clozapine treatment. J Clin Psychopharmacol 23:336–341
DeVylder JE, Koyanagi A, Unick J, Oh H, Nam B, Stickley A (2016) Stress sensitivity and psychotic experiences in 39 low- and middle-income countries. Schizophr Bull ., e-pub ahead of print. https://doi.org/10.1093/schbul/sbw044
Dishman BR, Ellenor GL, Lacro JP, Lohr JB (1994) Pharmacists’ role in clozapine therapy at a Veterans Affairs medical center. Am J Hosp Pharm 51:899–901
Dixon L, Perkins D, Calmes C (2009) Guideline watch (September 2009): practice guideline for the treatment of patients with schizophrenia. American Psychiatric Association, Washington, DC. http://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/schizophrenia-watch.pdf
Dixon LB, Dickerson F, Bellack AS, Bennett M, Dickinson D, Goldberg RW, Lehman A, Tenhula WN, Calmes C, Pasillas RM, Peer J, Kreyenbuhl J (2010) The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statements. Schizophr Bull 36:48–70
DoD/VA (2014) Report to the Congress in response to Senate Report 113–44, accompanying S.1197, the National Defense Authorization Act for Fiscal Year 2014
Elkis H, Buckley PF (2016) Treatment-resistant schizophrenia. Psychiatr Clin N Am 39:239–265
Every-Palmer S, Nowitz M, Stanley J, Grant E, Huthwaite M, Dunn H, Ellis PM (2016) Clozapine-treated patients have marked gastrointestinal hypomotility, the probable basis of life-threatening gastrointestinal complications: a cross sectional study. EBioMedicine in press. https://doi.org/10.1016/j.ebiom.2016.02.020
Falkai P, Wobrock T, Lieberman J, Glenthoj B, Gattaz WF, Möller H-J, WFSBP Task Force on Treatment Guidelines for Schizophrenia (2005) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 1: acute treatment of schizophrenia. World J Biol Psychiatry 6:132–191
Finley PR, Crismon L, Rush AJ (2003) Evaluating the impact of pharmacists in mental health: a systematic review. Pharmacotherapy 23:1634–1644
Fleischhacker WW, Uchida H (2014) Critical review of antipsychotic polypharmacy in the treatment of schizophrenia. Int J Neuropsychopharmacol 17:1083–1093
Freudenreich O, Goff DC, Henderson DC (2016) Antipsychotic drugs. In: Stern TA, Fava M, Wilens TE, Rosenbaum JF (eds) Massachusetts General Hospital Psychopharmacology and Neurotherapeutics. Elsevier, New York. Chapter 7, pp 72–85
Gadelha A, Souza Noto C, De Jesus MJ (2012) Pharmacological treatment of schizophrenia. Int Rev Psychiatry 24:489–498
Galletly C, Castle D, Dark F, Humberstone V, Jablensky A, Killackey E, Kulkarni J, McGorry P, Nielssen O, Tran N (2016) Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders. Aust N Z J Psychiatry 50:410–472
Gardner DM, Baldessarini RJ, Waraich P (2005) Modern antipsychotic drugs: A critical review. Can Med Assoc J 172:1703–1711
Gopalakirshna G, Ithman MH, Lauriello J (2016) Update on new and emerging treatments for schizophrenia. Psychiatr Clin N Am 39:217–238
Gould CM (2012a) Psychopharmacologic treatment of acute agitation: part I. Psychopharm Rev 47:49–56
Gould CM (2012b) Psychopharmacologic treatment of acute agitation: part II. Psychopharm Rev 47:65–72
Gracie A, Freeman D, Green S, Garety PA, Kuipers E, Hardy A, Ray K, Dunn G, Bebbington P, Fowler D (2007) The association between traumatic experience, paranoia and hallucinations: a test of the predictions of psychological models. Acta Psychiatr Scand 116:280–289
Grubaugh AL, Zinzow HM, Paul L, Egede LE, Frueh BC (2011) Trauma exposure and posttraumatic stress disorder in adults with severe mental illness: a critical review. Clin Psychol Rev 31:883–899
Gunderson EKE, Hourani LL (1998) The epidemiology of mental disorders in the U.S. Navy: the psychoses. Report No. 98–3. Naval Health Research Center, San Diego and Naval Medical Research and Development Command, Bethesda
Gurrera RJ, Parlee AC, Perry NL (2016) Aspiration pneumonia: an underappreciated risk of clozapine treatment. J Clin Psychopharmacol 36:174–176
Hamner MB, Frueh BC, Ulmer HG, Huber MG, Towmey TJ, Tyson C, Arana GW (2000) Psychotic features in chronic posttraumatic stress disorder and schizophrenia: comparative severity. J Nerv Ment Dis 188:217–221
Herrell R, Henter ID, Mojtabai R, Bartko JJ, Venable D, Susser E, Merikangas KR, Wyatt RJ (2006) First psychiatric hospitalizations in the US military: the National Collaborative Study of Early Psychosis and Suicide (NCSEPS). Psychol Med 36:1405–1415
Hibbard KR, Propst A, Frank DE, Wyse J (2009) Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. Psychosomatics 50:415–419
Hiemke C, Baumann P, Bergemann N, Conca A, Dietmaier O, Egberts K, Fric M, Gerlach M, Greiner C, Gründer G, Haen E, Havemann-Reinecke U, Sirot EJ, Kirchherr H, Laux G, Lutz UC, Messer T, Müller MJ, Pfuhlmann B, Rambeck B, Riederer P, Schoppek B, Stingl J, Uhr M, Ulrich S, Waschgler R, Zernig G (2011) AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: Update 2011. Pharmacopsychiatry 44:195–235
Hoge CW, Lesikar SE, Guevara R, Lange J, Brundage JF, Engel CC Jr, Messer SC, Orman DT (2002) Mental disorders among U.S. military personnel in the 1990s: association with high levels of health care utilization and early military attrition. Am J Psychiatry 159:1576–1583
Hoge CW, Castro CA, Messer SC, McGurk D, Cotting DI, Koffman RL (2004) Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. N Engl J Med 351:13–22
Jablensky A (2006) Subtyping schizophrenia: implications for genetic research. Mol Psychiatry 11:815–836
Jones PB, Barnes TRE, Davies L, Dunn G, Lloyd H, Hayhurst KP, Murray RM, Markwick A, Lewis SW (2006) Randomized controlled trial of the effect on quality of life of second- vs. first-generation antipsychotic drugs in schizophrenia. Cost utility of the latest antipsychotic drugs in schizophrenia study (CUtLASS 1). Arch Gen Psychiatry 63:1079–1087
Kapur S, Seeman P (2001) Does fast dissociation from the dopamine D2 receptor explain the action of atypical antipsychotics?: a new hypothesis. Am J Psychiatry 158:360–369
Karagianis JL, Phillips LC, Hogan KP, LeDrew KK (1999) Clozapine-associated neuroleptic malignant syndrome: two new cases and a review of the literature. Ann Pharmacother 33:623–630
Kaštelan A, Frančišković T, Moro L, Rončević-Gržeta I, Grković J, Jurcan V, Lesica T, Graovac M, Girotto I (2007) Psychotic symptoms in combat-related post-traumatic stress disorder. Mil Med 172:273–277
Khan AY, Preskorn SH (2005) Examining concentration-dependent toxicity of clozapine: role of therapeutic drug monitoring. J Psychiatr Pract 11:289–301
Kilcommons AM, Morrison AP (2005) Relationships between trauma and psychosis: an exploration of cognitive and dissociative factors. Acta Psychiatr Scand 112:351–359
Kishimoto T, Nitta M, Borenstein M, Kane JM, Correll CU (2013) Long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studies. J Clin Psychiatry 74:957–965
Kishimoto T, Robenzadeh A, Leucht C, Leucht S, Watanabe K, Mimura M, Borenstein M, Kane JM, Correll CU (2014) Long-acting injectable vs. oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trials. Schizophr Bull 40:192–213
Kozarić-Kovačić D, Borovečki A (2005) Prevalence of psychotic comorbidity in combat-related post-traumatic stress disorder. Mil Med 170:223–226
Lambert BL, Cunningham FE, Miller DR, Dalack GW, Hur K (2006) Diabetes risk associated with use of olanzapine, quetiapine, and risperidone in Veterans Health Administration patients with schizophrenia. Am J Epidemiol 164:672–681
Lauriello J, Bustillo J, Keith SJ (1999) A critical review of research on psychosocial treatment of schizophrenia. Biol Psychiatry 46:1409–1417
Lee J, Bies R, Takeuchi H, Fervaha G, Bhaloo A, Powell V, Remington G (2016) Quantifying intraindividual variations in plasma clozapine levels: a population pharmacokinetic approach. J Clin Psychiatry 77:681–687
Lenzenweger MF, Lane MC, Loranger AW, Kessler RC (2007) DSM-IV personality disorders in the National Comorbidity Survey Replication. Biol Psychiatry 62:553–564
Leslie DL, Rosenheck RA (2000) Health care for public-sector and privately insured populations. Psychiatr Serv 51:650–655
Leslie DL, Rosenheck RA (2003) Benchmarking the quality of schizophrenia pharmacotherapy: a comparison of the Department of Veterans Affairs and the private sector. J Ment Health Pol Econ 6:113–121
Leucht C, Heres S, Kane JM, Kissling W, Davis JM, Leucht S (2011) Oral versus depot antipsychotic drugs for schizophrenia—a critical systematic review and meta-analysis of randomised long-term trials. Schizophr Res 127:83–92
Leucht S, Tardy M, Komossa K, Heres S, Kissling W, Salanti G, Davis JM (2012) Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet 379:2063–2071
Lewis S, Lieberman J (2008) CATIE and CUtLASS: can we handle the truth? Br J Psychiatry 192:161–163
Lewis SW, Barnes TRE, Davies L, Murray RM, Dunn G, Hayhurst KP, Markwick A, Lloyd H, Jones PB (2006) Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia. Schizophr Bull 32:715–723
Lieberman JA (1998) Maximizing clozapine therapy: managing side effects. J Clin Psychiatry 59(suppl 3):38–43
Lieberman JA, Stroup TS (2011) The NIMH-CATIE schizophrenia study: what did we learn? Am J Psychiatry 168:770–775
Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, and Hsaio JK for the CATIE Investigators (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353:1209–1223
Lindenmayer J-P, Kaur A (2016) Antipsychotic management of schizoaffective disorder: a review. Drugs 76:589–564. [REFERENCE MUST BE PURCHASED]
Lobeck F, Traxler WT, Bobinet DD (1989) The cost-effectiveness of a clinical pharmacy service in an outpatient mental health clinic. Hosp Comm Psychiatry 40:643–645
Malhi GS, Green M, Fagiolini A, Peselow ED, Kumari V (2008) Schizoaffective disorder: diagnostic issues and future recommendations. Bipol Disord 10:215–230
Marshall M, Rathbone J (2011) Early intervention for psychosis (review). Cochrane Databas Syst Rev (Issue 6):CD004718. https://doi.org/10.1002/14651858.CD004718.pub3
McCarthy JF, Blow FC, Valenstein M, Fischer EP, Owen RR, Barry KL, Hudson TJ, Ignacio RV (2007) Veterans Affairs health system and mental health treatment retention among patients with serious mental illness: evaluating accessibility and availability barriers. Health Serv Res 42:1042–1060
McCarthy S, Chinman M, Henze K, Sweeney P (2013) Peer specialist toolkit: implementing peer support services in VHA
McCarthy-Jones S, Longden E (2015) Auditory verbal hallucinations in schizophrenia and post-traumatic stress disorder: common phenomenology, common cause, common interventions? Front Psychol 6(12):1071
McCarthy-Jones S, Trauer T, Mackinnon A, Sims E, Thomas N, Copolov DL (2014) A new phenomenological survey of auditory hallucinations: evidence for subtypes and implications for theory and practice. Schizophr Bull 40:225–235
McEvoy JP, Meyer JM, Goff DC, Nasrallah HA, Davis SM, Sullivan L, Meltzer HY, Hsiao J, Scott Stroup T, Lieberman JA (2005) Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr Res 80:19–32
McEvoy JP, Lieberman JP, Stroup TS, Davis SM, Meltzer HY, Rosenheck RA, Swartz MS, Perkins DO, Keefe RSE, Davis CE, Severe J, Hsiao JK, for the CATIE Investigators (2006) Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry 163:600–610
McGorry PD, Nelson B, Amminger P, Bechdolf A, Francey SM, Berger G, Riecher-Rossler A, Klosterkotter J, Ruhrmann S, Schultze-Lutter F, Nordentoft M, Hickie I, McGuire P, Berk M, Chen EYH, Keshavan MS, Young AR (2009) Intervention in individuals at ultra-high risk for psychosis: a review and future directions. J Clin Psychiatry 70:1206–1212
McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D (2004) A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2:13. https://doi.org/10.1186/1741-7015-2-13
McGrath J, Saha S, Chant D, Welham J (2008) Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 30:67–76
McGuire J, Clark S (2009) The veterans justice outreach initiative. White Paper, Department of Veterans Affairs. (downloaded 8/8/16). http://justiceforvets.org/sites/default/files/files/VJO%20White%20Paper.pdf
Meltzer HY, Matsubara S, Lee J-C (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 251:238–246
Mews MR, Quante A (2013) Comparative efficacy and acceptability of existing pharmacotherapies for delusional disorder. J Clin Psychopharmacol 33:512–519
Meyer J, Loh C, Leckband SG, Boyd JA, Wirshing WC, Pierre JM, Wirshing D (2006) Prevalence of the metabolic syndrome in veterans with schizophrenia. J Psychiatr Pract 12:5–10
Miyamoto S, Miyake N, Jarskog LF, Fleischhacker WW, Leiberman JA (2012) Pharmacology treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry 17:1206–1227
Miyamoto S, Jarskog LF, Fleischhacker WW (2014) New therapeutic approaches for treatment-resistant schizophrenia: a look to the future. J Psychiatr Res 58:1–6
Mokhtari M, Rajarethinam R (2014) Early intervention and the treatment of prodrome in schizophrenia: a review of recent developments. J Psychiatr Pract 19:375–385
Mouaffak F, Tranulis C, Gourevitch R, Poirier M-F, Douki S, Olié J-P, Lôo H, Gourian D (2006) Augmentation strategies of clozapine with antipsychotics in the treatment of ultraresistant schizophrenia. Clin Neuropharmacol 29:28–33
Muenzenbaier K, Spei E, Gross DR (2010) Complex posttraumatic stress disorder in men with serious mental illness: a reconceptualization. Am J Psychother 64:257–268
Mueser KT, Deavers F, Penn DL, Cassisi JE (2013) Psychosocial treatments for schizophrenia. Ann Rev Clin Psychol 9:465–497
National Institute for Health and Clinical Excellence (NICE) (2014) Psychosis and schizophrenia in adults: prevention and management. Clinical guideline 178. https://www.nice.org.uk/guidance/cg178
Nielsen J, Damkier P, Lublin H, Taylor D (2011) Optimizing clozapine treatment. Acta Psychiatr Scand 123:411–422
Nielsen J, Correll CU, Manu P, Kane JM (2013) Termination of clozapine treatment due to medical reasons: when is it warranted and how can it be avoided? J Clin Psychiatry 74:603–613
Norredam M, Jensen M, Ekstrøm M (2011) Psychotic symptoms in refugees diagnosed with PTSD: a series of case reports. Nord J Psychiatry 65:283–288
Olivares JM, Sermon J, Hemels M, Schreiner A (2013) Definitions and drivers of relapse in patients with schizophrenia: a systematic literature review. Ann General Psychiatry 12:32. https://doi.org/10.1186/1744-859X-12-32
Owen RR, Feng W, Thrush CR, Hudson TJ, Austen MA (2001) Variations in prescribing practices for novel antipsychotic medications among Veterans Affairs hospitals. Psychiatr Serv 52:1523–1525
Palmer SE, McLean RM, Ellis PM, Harrison-Woolrych M (2008) Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 cases. J Clin Psychiatry 69:759–768
Pearlson GD, Clementz BA, Sweeney JA, Keshavan MS, Tamminga CA (2016) Does biology transcend the symptom-based boundaries of psychosis? Psychiatr Clin N Am 39:165–174
Perkins DO, Gu H, Boteva K, Lieberman JA (2005) Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry 162:1785–1804
Perry PJ, Miller DD, Arndt SV, Cadoret RJ (1991) Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry 148:231–235
Plaze M, Paillère-Martinot M-L, Penttilä J, Januel D, de Beaurepaire R, Bellivier F, Andoh J, Galinowski A, Gallarda T, Artiges E, Olié J-P, Mangin J-F, Martinot J-L, Cachia A (2011) “Where do auditory hallucinations come from?” – a brain morphometry study of schizophrenia patients with inner or outer space hallucinations. Schizophr Bull 37:212–221
Pollack S, Woerner MG, Howard A, Fireworker RB, Kane JM (1998) Clozapine reduces rehospitalization among schizophrenia patients. Psychopharmacol Bull 34:89–92
Remington G, Agid O, Foussias G, Ferguson L, McDonald K, Powell V (2013) Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold? Psychopharmacology 225:505–518
Rosell DR, Futterman SE, McMaster A, Seiver LJ (2014) Schizotypal personality disorder: a current review. Curr Psychiatry Rep 16:452. https://doi.org/10.1007/s11920-014-0452-1
Rosenheck R, Cramer J, Allan E, Erdos J, Frisman LK, Xu W, Thomas J, Henderson W, Charney D, for the Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia (1999) Arch Gen Psychiatry 56:565–572
Saha S, Chant D, Welham J, McGrath J (2005) A systematic review of the prevalence of schizophrenia. PLoS Med 2:e141. https://doi.org/10.1371/journal.pmed.0020141
Samara MT, Leucht C, Leeflang MM, Anghelescu I-G, Chung Y-C, Crespo-Facorro B, Elkis H, Hatta K, Giegling I, Kane JM, Kayo M, Lambert M, Lin C-H, Moller H-J, Pelayo-Teran JM, Riedel M, Rujescu D, Schimmelmann BG, Serretti A, Correll CU, Leucht S (2015) Early improvement as a predictor of later response to antipsychotics in schizophrenia: a diagnostic test review. Am J Psychiatry 172:617–629
Sautter FJ, Brailey K, Uddo MM, Hamilton MF, Beard MG, Borges AH (1999) PTSD and comorbid psychotic disorder: comparison with veterans diagnosed with PTSD or psychotic disorder. J Traum Stress 12:73–88
Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, Hametner E-M, Poewe W, Rascol O, Goetz CG, Sampaio C (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord 26(suppl 3):S42–S80
Sernyak MJ (2007) Implementation of monitoring and management guidelines for second-generation antipsychotics. J Clin Psychiatry 68(suppl 4):14–18
Shean GD (2009) Evidence-based psychosocial practices and recovery from schizophrenia. Psychiatry 72:307–320
Siskind D, McCartney L, Goldschlager R, Kisely S (2016) Clozapine v. first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. Br J Psychiatry. e-pub ahead of print 1–8. https://doi.org/10.1192/bjp.bp.115.177261
Stephane M, Thuras P, Nasrallah H, Georgopoulos AP (2003) The internal structure of the phenomenology of auditory verbal hallucinations. Schizophr Res 61:185–193
Strauss JJ, Calhoun PS, Marx CE, Stechuchak KM, Oddone EZ, Swartz MS, Butterfield MI (2006) Comorbid posttraumatic stress disorder is associated with suicidality in male veterans with schizophrenia or schizoaffective disorder. Schizophr Res 84:165–169
Sun FF, Stock EM, Copeland LA, Zeber JE, Ahmedani BK, Morissette SB (2014) Polypharmacy with antipsychotic drugs in patients with schizophrenia: trends in multiple health care systems. Am J Health Syst Pharm 71:728–738
Suzuki T, Remington G, Mulsant BH, Uchida H, Rajji TK, Graff-Guerrero A, Mimura M, Mamo DC (2012) Defining treatment-resistant schizophrenia and response to antipsychotics: a review and recommendation. Psychiatry Res 197:1–6
Takeuchi H, Suzuki T, Uchida H, Watanabe K, Mimura M (2012) Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms. Schizophr Res 134:219–225
Taylor DM, Smith L, Gee SH, Nielsen J (2012) Augmentation of clozapine with a second antipsychotic – a meta-analysis. Acta Psychiatr Scand 125:15–24
Teh CF, Kilbourne AM, McCarthy JF, Welsh D, Blow FC (2008) Gender differences in health-related quality of life for veterans with serious mental illness. Psychiatr Serv 59:663–669
Tranulis C, Mouaffak F, Chouchana L, Stip E, Gourevitch R, Poirier MF, Olié J-P, Lôo H, Gourion D (2006) Somatic augmentation strategies in clozapine resistance – what facts? Clin Neuropharmacol 29:34–44
Tsuang MT, Tohen M (2002) Textbook in psychiatric epidemiology, 2nd edn. Wiley-Liss. Chapter 15, New York, pp 365–387
U.S. Food and Drug Administration (2015) FDA drug safety communication: FDA modifies monitoring for neutropenia associated with schizophrenia medicine clozapine; approves new shared REMS program for all clozapine medicines (Sept. 15). http://www.fda.gov/Drugs/DrugSafety/ucm461853.htm
Uchida H, Suzuki T, Takeuchi H, Arenovich T, Mamo DC (2011) Low dose vs. standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysis. Schizophr Bull 37:788–799
Veterans Health Administration (2014) VHA handbook 1140.01: community residential care program. Available at: http://www.va.gov/vhapublications/publications.cfm?pub=2&order=asc&orderby=pub_Number
Villareal G, Hamner MB, Canive JM, Robert S, Calais LA, Durklaski V, Zhai Y, Qualis C (2016) Efficacy of quetiapine monotherapy in posttraumatic stress disorder: a randomized, placebo-controlled trial. Am J Psychiatry., (AJP in Advance). e-pub ahead of print. https://doi.org/10.1176/appi.ajp.2016.15070967
Walker E, Mittal V, Tessner K (2008) Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Ann Rev Clin Psychol 4:189–216
Warnez S, Alessi-Severini S (2014) Clozapine: a review of clinical practice guidelines and prescribing trends. BMC Psychiatry 14:102
Watkins KE, Smith B, Akincigil A, Sorbero ME, Paddock S, Woodroffe A, Huang C, Crystal S, Pincus HA (2016) The quality of medication treatment for mental disorders in the Department of Veterans Affairs and in private-sector plans. Psychiatr Serv 67:391–396
Weissman EM (2002) Antipsychotic prescribing practices in the Veterans Healthcare Administration – New York metropolitan region. Schizophr Bull 28:31–42
Williams T, Purvis TL (2012) Development of an outpatient pharmacist-managed clozapine clinic. Am J Health Syst Pharm 69:1192–1195
Wilson ALG, Messer SC, Hoge CW (2009) U.S. military mental health care utilization and attrition prior to the wars in Iraq and Afghanistan. Soc Psychiatry Psychiatr Epidemiol 44:473–481
World Health Organization (2016) International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). Chapter V: “Mental and behavioral disorders”, F20–F29 “Schizophrenia, schizotypal and delusional disorders”
Yee CM, Javitt DC, Miller GA (2015) Replacing DSM categorical analyses with dimensional analyses in psychiatry research: the research domain criteria initiative. JAMA Psychiatr 72:1159–1160
Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, Hallgren M, McGorry PD (2003) Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 60:21–32
Yusufi B, Mukherjee S, Flanagan R, Paton C, Dunn G, Page E, Barnes TRE (2007) Prevalence and nature of side effects during clozapine maintenance treatment and the relationship with clozapine dose and plasma concentration. Int Clin Psychopharmacol 22:238–243
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Gurrera, R.J., Perry, N.L. (2018). Psychosis: Schizophrenia and Related Disorders. In: Roberts, L., Warner, C. (eds) Military and Veteran Mental Health. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7438-2_21
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7438-2_21
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-7436-8
Online ISBN: 978-1-4939-7438-2
eBook Packages: MedicineMedicine (R0)