Skip to main content

Co-occurring Substance and Mental Health Disorders

  • Chapter
  • First Online:
Military and Veteran Mental Health

Abstract

The terms “dual diagnosis” and “co-occurring” are used to refer to patients with both psychiatric and substance use disorders, but recent research has broadened the concept to identify patients with the presence of any two or more medical conditions as well as numerous related psychosocial conditions that derive, to varying degrees, from the medical diagnoses. Traditionally, medical care for the dually diagnosed patient has focused treatment on the individual diseases and has had unintended consequences in patients with dual diagnoses, namely, the potential for high treatment burden (e.g., polypharmacy, frequent appointments, multiple procedures) or worsening of one disease by treatment of another. Within the mental health care system, this siloing (i.e., operating in isolation) of healthcare delivery approach has led to fragmented and stymied mental health care delivery. This chapter reviews the evolution of treatment for the dually diagnosed individual and veteran from the sequential approach to parallel and finally integrated approach that affords the most benefits with the least harm.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Albanese MJ, Khantzian EJ, Murphy SL, Green AI (1994) Decreased substance use in chronically psychotic patients treated with clozapine. Am J Psychiatry 151(5):780–781

    CAS  PubMed  Google Scholar 

  • Alderman CP, McCarthy LC, Condon JT, Marwood AC, Fuller JR (2009) Topiramate in combat-related posttraumatic stress disorder. Ann Pharmacother 43(4):635–641

    Article  CAS  PubMed  Google Scholar 

  • Alemany S, Arias B, Fatjó-Vilas M, Villa H, Moya J, Ibanez M, Ortet G, Gasto C, Fananas L (2014) Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatr Scand 129(1):54–62

    Article  CAS  PubMed  Google Scholar 

  • Ames G, Cunradi C (2004) Alcohol use and preventing alcohol-related problems among young adults in the military. Alcohol Res Health 28(4):252–258

    Google Scholar 

  • Andréasson S, Engström A, Allebeck P, Rydberg U (1987) Cannabis and schizophrenia A longitudinal study of swedish conscripts. Lancet 330(8574):1483–1486

    Article  Google Scholar 

  • Arias A, Feinn R, Oncken C, Covault J, Kranzler HR (2010) Placebo-controlled trial of zonisamide for the treatment of alcohol dependence. J Clin Psychopharmacol 30(3):318

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arseneault L, Cannon M, Poulton R, Murray R, Caspi A, Moffitt TE (2002) Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ 325(7374):1212–1213

    Article  PubMed  PubMed Central  Google Scholar 

  • Ballenger JC, Davidson JR, Lecrubier Y, Nutt DJ, Foa EB, Kessler RC, McFarlane AC (2000) Consensus statement on posttraumatic stress disorder from the International Consensus Group on Depression and Anxiety. J Clin Psychiatry 61(Suppl 5):60–66

    PubMed  Google Scholar 

  • Batki SL, Pennington DL, Lasher B, Neylan TC, Metzler T, Waldrop A, Delucchi K, Herbst E (2014) Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial. Alcohol Clin Exp Res 38(8):2169–2177

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bellack AS, Bennett ME, Gearon JS, Brown CH, Yang Y (2006) A randomized clinical trial of a new behavioral treatment for drug abuse in people with severe and persistent mental illness. Arch Gen Psychiatry 63(4):426–432

    Article  PubMed  Google Scholar 

  • Berlant JL (2000) Topiramate in posttraumatic stress disorder: preliminary clinical observations. J Clin Psychiatry 62:60–63

    Google Scholar 

  • Berlant J, van Kammen DP (2002) Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report. J Clin Psychiatry 63(1):15–20

    Article  CAS  PubMed  Google Scholar 

  • Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47(4):351–354

    Article  CAS  PubMed  Google Scholar 

  • Bernardy NC, Hamblen JL, Friedman MJ, Kivlahan DR (2011) Co-occurring posttraumatic stress disorder and substance use disorder: recommendations for management and implementation in the Department of Veterans Affairs. J Dual Diagn 7(4):242–261

    Article  Google Scholar 

  • Black AC, Rosen MI (2011) A money management-based substance use treatment increases valuation of future rewards. Addict Behav 36(1):125–128

    Article  PubMed  Google Scholar 

  • Boehnlein JK, Kinzie JD (2007) Pharmacologic reduction of CNS noradrenergic activity in PTSD: the case for clonidine and prazosin. J Psychiatr Pract 13(2):72–78

    Article  PubMed  Google Scholar 

  • Boehnlein JK, Kinzie JD, Sekiya U, Riley C, Pou K, Rosborough B (2004) A ten-year treatment outcome study of traumatized Cambodian refugees. J Nerv Ment Dis 192(10):658–663

    Article  PubMed  Google Scholar 

  • Bowe A, Rosenheck R (2015) PTSD and substance use disorder among veterans: characteristics, service utilization and pharmacotherapy. J Dual Diagn 11(1):22–32

    Article  PubMed  Google Scholar 

  • Brady KT, Sinha R (2007) Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress. Focus 5(2):229–239

    Article  Google Scholar 

  • Brady KT, Dansky BS, Back SE, Foa EB, Carroll KM (2001) Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: preliminary findings. J Subst Abus Treat 21(1):47–54

    Article  CAS  Google Scholar 

  • Brady KT, Sonne S, Anton RF, Randall CL, Back SE, Simpson K (2005) Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcohol Clin Exp Res 29(3):395–401

    Article  CAS  PubMed  Google Scholar 

  • Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS (1997) Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am J Psychiatr 154:624–629

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunette MF, Drake RE, Xie H, McHugo GJ, Green AI (2006) Clozapine use and relapses of substance use disorder among patients with co-occurring schizophrenia and substance use disorders. Schizophr Bull 32(4):637–643

    Article  PubMed  PubMed Central  Google Scholar 

  • Buckley P, Psych M, Thompson P, Way L, Meltzer HY (1994) Substance abuse among patients with treatment-resistant schizophrenia: characteristics and implications for clozapine therapy. Am J Psychiatry 151(3):385–389

    Article  CAS  PubMed  Google Scholar 

  • Burnam MA, Morton SC, McGlynn EA, Petersen LP, Stecher BM, Hayes C, Vaccaro JV (1996) An experimental evaluation of residential and nonresidential treatment for dually diagnosed homeless adults. J Addict Dis 14(4):111–134

    Article  Google Scholar 

  • Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, Taylor A, Arseneault L, Williams B, Braithwaite A (2005) Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 57(10):1117–1127

    Article  CAS  PubMed  Google Scholar 

  • Chappell P, Smith M, Kilts C, Bissette G, Ritchie J, Anderson C, Nemeroff C (1986) Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress. J Neurosci 6(10):2908–2914

    CAS  PubMed  Google Scholar 

  • Cheng A-L, Lin H, Kasprow W, Rosenheck RA (2007) Impact of supported housing on clinical outcomes analysis of a randomized trial using multiple imputation technique. J Nerv Ment Dis 195(1):83

    Article  PubMed  PubMed Central  Google Scholar 

  • Croop RS, Faulkner EB, Labriola DF (1997) The safety profile of naltrexone in the treatment of alcoholism: results from a multicenter usage study. Arch Gen Psychiatry 54(12):1130–1135

    Article  CAS  PubMed  Google Scholar 

  • Desai RA, Harpaz-Rotem I, Najavits LM, Rosenheck RA (2008) Impact of the seeking safety program on clinical outcomes among homeless female veterans with psychiatric disorders. Psychiatr Serv 59(9):996–1003

    Article  PubMed  Google Scholar 

  • Di Forti M, Iyegbe C, Sallis H, Kolliakou A, Falcone MA, Paparelli A, Sirianni M, La Cascia C, Stilo SA, Marques TR (2012) Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry 72(10):811–816

    Article  PubMed  CAS  Google Scholar 

  • Drake RE, Mueser KT, Clark RE, Wallach MA (1996) The course, treatment, and outcome of substance disorder in persons with severe mental illness. Am J Orthop 66(1):42

    Article  CAS  Google Scholar 

  • Drake RE, Mercer-McFadden C, Mueser KT, McHugo GJ, Bond GR (1998) Review of integrated mental health and substance abuse treatment for patients with dual disorders. Schizophr Bull 24(4):589–608

    Article  CAS  PubMed  Google Scholar 

  • Drake RE, Essock SM, Shaner A, Carey KB, Minkoff K, Kola L, Lynde D, Osher FC, Clark RE, Rickards L (2001) Implementing dual diagnosis services for clients with severe mental illness. Psychiatr Serv 52(4):469–476

    Article  CAS  PubMed  Google Scholar 

  • Drebing CE, Fleitas R, Moore A, Krebs C, Van Ormer A, Penk W, Seibyl C, Rosenheck R (2002) Patterns in work functioning and vocational rehabilitation associated with coexisting psychiatric and substance use disorders. Rehabil Couns Bull 46(1):5–13

    Article  Google Scholar 

  • Drebing CE, Ormer E, Krebs C, Rosenheck R, Rounsaville B, Herz L, Penk W (2005) The impact of enhanced incentives on vocational rehabilitation outcomes for dually diagnosed veterans. J Appl Behav Anal 38(3):359–372

    Article  PubMed  PubMed Central  Google Scholar 

  • Drebing CE, Van Ormer EA, Mueller L, Hebert M, Penk WE, Petry NM, Rosenheck R, Rounsaville B (2007) Adding contingency management intervention to vocational rehabilitation: outcomes for dually diagnosed veterans. J Rehabil Res Dev 44(6):851–865

    Article  PubMed  Google Scholar 

  • Edens EL, Mares AS, Tsai J, Rosenheck RA (2011) Does active substance use at housing entry impair outcomes in supported housing for chronically homeless persons? Psychiatr Serv 62(2):171–178

    Article  PubMed  Google Scholar 

  • Fireman M, Indest DW, Blackwell A, Whitehead AJ, Hauser P (2005) Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a comanagement model of care. Clin Infect Dis 40(Supplement 5):S286–S291

    Article  PubMed  Google Scholar 

  • Foa EB, Dancu CV, Hembree EA, Jaycox LH, Meadows EA, Street GP (1999) A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims. J Consult Clin Psychol 67(2):194

    Article  CAS  PubMed  Google Scholar 

  • Foa EB, Yusko DA, McLean CP, Suvak MK, Bux DA, Oslin D, O’Brien CP, Imms P, Riggs DS, Volpicelli J (2013) Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: a randomized clinical trial. JAMA 310(5):488–495

    Article  CAS  PubMed  Google Scholar 

  • Fowler JS, Logan J, Wang G-J, Volkow ND (2003) Monoamine oxidase and cigarette smoking. Neurotoxicology 24(1):75–82

    Article  CAS  PubMed  Google Scholar 

  • Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R (2012) Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. J Psychopharmacol 26(7):958–972

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Freud S (2005) Civilization and its discontents. WW Norton & Company

    Google Scholar 

  • Gamache G, Rosenheck R, Tessler R (2000) Choice of provider among homeless people with mental illness: veterans and the VA. Psychiatr Serv 51(8):1024–1017

    Article  CAS  PubMed  Google Scholar 

  • Gamache G, Rosenheck R, Tessler R (2001) The proportion of veterans among homeless men: a decade later. Soc Psychiatry Psychiatr Epidemiol 36(10):481–485

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez G, Rosenheck RA (2002) Outcomes and service use among homeless persons with serious mental illness and substance abuse. Psychiatr Serv 53(4):437–446

    Article  PubMed  Google Scholar 

  • Goodwin DW, Schulsinger F, Knop J, Mednick S, Guze SB (1977) Psychopathology in adopted and nonadopted daughters of alcoholics. Arch Gen Psychiatry 34(9):1005–1009

    Article  CAS  PubMed  Google Scholar 

  • Harley M, Kelleher I, Clarke M, Lynch F, Arseneault L, Connor D, Fitzpatrick C, Cannon M (2010) Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychol Med 40(10):1627–1634

    Article  CAS  PubMed  Google Scholar 

  • Harmon RJ, Riggs PD (1996) Clonidine for posttraumatic stress disorder in preschool children. J Am Acad Child Adolesc Psychiatry 35(9):1247–1249

    Article  CAS  PubMed  Google Scholar 

  • Harris KM, DeVries A, Dimidjian K (2004) Trends in naltrexone use among members of a large private health plan. Psychiatr Serv 55(3):221

    Article  PubMed  Google Scholar 

  • Hembree EA, Foa EB (2000) Posttraumatic stress disorder: psychological factors and psychosocial interventions. J Clin Psychiatry 61(Suppl 7):33–39

    PubMed  Google Scholar 

  • Hien DA, Nunes E, Levin FR, Fraser D (2000) Posttraumatic stress disorder and short-term outcome in early methadone treatment. J Subst Abus Treat 19(1):31–37

    Article  CAS  Google Scholar 

  • Hien DA, Wells EA, Jiang H, Suarez-Morales L, Campbell AN, Cohen LR, Miele GM, Killeen T, Brigham GS, Zhang Y (2009) Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders. J Consult Clin Psychol 77(4):607

    Article  PubMed  PubMed Central  Google Scholar 

  • Hoff RA, Rosenheck RA (1998) Long-term patterns of service use and cost among patients with both psychiatric and substance abuse disorders. Med Care 36(6):835–843

    Article  CAS  PubMed  Google Scholar 

  • Hoff RA, Rosenheck RA (1999) The cost of treating substance abuse patients with and without comorbid psychiatric disorders. Psychiatr Serv 50(10):1309–1315

    Article  CAS  PubMed  Google Scholar 

  • Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA (2008) Mild traumatic brain injury in US soldiers returning from Iraq. N Engl J Med 358(5):453–463

    Article  CAS  PubMed  Google Scholar 

  • Houston JE, Murphy J, Adamson G, Stringer M, Shevlin M (2008) Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophr Bull 34(3):580–585

    Article  PubMed  Google Scholar 

  • Iheanacho T, Issa M, Marienfeld C, Rosenheck R (2013) Use of naltrexone for alcohol use disorders in the Veterans’ Health Administration: a national study. Drug Alcohol Depend 132(1):122–126

    Article  CAS  PubMed  Google Scholar 

  • Jacobsen LK, Southwick SM, Kosten TR (2001) Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatr 158(8):1184–1190

    Article  CAS  PubMed  Google Scholar 

  • Johnson BA (2004) Progress in the development of topiramate for treating alcohol dependence: from a hypothesis to a proof-of-concept study. Alcohol Clin Exp Res 28(8):1137–1144

    Article  CAS  PubMed  Google Scholar 

  • Johnson BA, Ait-Daoud N (2010) Topiramate in the new generation of drugs: efficacy in the treatment of alcoholic patients. Curr Pharm Des 16(19):2103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, McKay A, Ait-Daoud N, Addolorato G, Anton RF (2008) Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. Arch Intern Med 168(11):1188–1199

    Article  CAS  PubMed  Google Scholar 

  • Kasprow WJ, Rosenheck R, Frisman L, DiLella D (1999) Residential treatment for dually diagnosed homeless veterans: a comparison of program types. Am J Addict 8(1):34–43

    Article  CAS  PubMed  Google Scholar 

  • Khantzian EJ (1987) The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. The Cocaine Crisis: Springer, p 65–74

    Google Scholar 

  • Kinzie JD, Leung P (1989) Clonidine in Cambodian patients with posttraumatic stress disorder. J Nerv Ment Dis 177(9):546–550

    Article  CAS  PubMed  Google Scholar 

  • Kolb LC (1991) PTSD: psychopathology and the startle response. Psychiatry Q 62(3):233–250

    Article  CAS  Google Scholar 

  • Konings M, Stefanis N, Kuepper R, De Graaf R, Have M t, Van Os J, Bakoula C, Henquet C (2012) Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychol Med 42(01):149–159

    Article  CAS  PubMed  Google Scholar 

  • Koob GF (2008) A role for brain stress systems in addiction. Neuron 59(1):11–34

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242(4879):715–723

    Article  CAS  PubMed  Google Scholar 

  • Krupitsky E, Burakov A, Romanova T, Dunaevsky I, Strassman R, Grinenko A (2002) Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up. J Subst Abus Treat 23(4):273–283

    Article  Google Scholar 

  • Krupitsky EM, Burakov AM, Dunaevsky IV, Romanova TN, Slavina TY, Grinenko AY (2007) Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence. J Psychoactive Drugs 39(1):13–19

    Article  PubMed  Google Scholar 

  • Littrell KH, Petty RG, Hilligoss NM, Peabody CD, Johnson CG (2001) Olanzapine treatment for patients with schizophrenia and substance abuse. J Subst Abus Treat 21(4):217–221

    Article  CAS  Google Scholar 

  • Marcus P, Snyder R (1995) Reduction of comorbid substance abuse with clozapine. Am J Psychiatry 152(6):959

    CAS  PubMed  Google Scholar 

  • Maremmani I, Zolesi O, Aglietti M, Marini G, Tagliamonte A, Shinderman M, Maxwell S (2000) Methadone dose and retention during treatment of heroin addicts with Axis I psychiatric comorbidity. J Addict Dis 19(2):29–41

    Article  CAS  PubMed  Google Scholar 

  • Maremmani I, Pacini M, Lubrano S, Perugi G, Tagliamonte A, Pani PP, Gerra G, Shinderman M (2007) Long-term outcomes of treatment-resistant heroin addicts with and without DSM-IV axis I psychiatric comorbidity (dual diagnosis). Eur Addict Res 14(3):134–142

    Article  Google Scholar 

  • Mares AS, Kasprow WJ, Rosenheck RA (2004) Outcomes of supported housing for homeless veterans with psychiatric and substance abuse problems. Ment Health Serv Res 6(4):199–211

    Article  PubMed  Google Scholar 

  • Marienfeld C, Rosenheck RA (2013) National psychotropic prescription dispensation among dually diagnosed patients. Advances Dual Diagn 6(1):34–44

    Article  Google Scholar 

  • Markou A, Kosten TR, Koob GF (1998) Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 18(3):135–174

    Article  CAS  PubMed  Google Scholar 

  • Martinotti G, Andreoli S, Di Nicola M, Di Giannantonio M, Sarchiapone M, Janiri L (2008) Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholics. Hum Psychopharmacol Clin Exp 23(5):417–424

    Article  CAS  Google Scholar 

  • McCarthy E, Richardson G, Jane S, O’Brien E, Keegan K, Bassett G, Petrakis I (2009) Modified CPT-C for the treatment of veterans diagnosed with PTSD and alcohol dependence. Veteran’s Administration Mental Health Conference

    Google Scholar 

  • McEvoy JP, Freudenreich O, Levin ED, Rose JE (1995) Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology 119(1):124–126

    Article  CAS  PubMed  Google Scholar 

  • McGhee LL, Maani CV, Garza TH, Gaylord KM, Black IH (2008) The correlation between ketamine and posttraumatic stress disorder in burned service members. J Trauma Acute Care Surg 64(2):S195–S199

    Article  CAS  Google Scholar 

  • McGovern MP, Matzkin AL, Giard J (2007) Assessing the dual diagnosis capability of addiction treatment services: the Dual Diagnosis Capability in Addiction Treatment (DDCAT) index. J Dual Diagn 3(2):111–123

    Article  Google Scholar 

  • Merikangas KR, Prusoff BA, Weissman MM (1988) Parental concordance for affective disorders: psychopathology in offspring. J Affect Disord 15(3):279–290

    Article  CAS  PubMed  Google Scholar 

  • Merikangas KR, Risch N, Weissman MM (1994) Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychol Med 24(01):69–80

    Article  CAS  PubMed  Google Scholar 

  • Miller W, Rollnick S (1991) Motivational interviewing: preparing people to change addictive behavior. Guilford, New York

    Google Scholar 

  • Modesto-Lowe V, Kranzler HR (1999) Diagnosis and treatment of alcohol-dependent patients with comorbid psychiatric disorders. Alcohol Res Health 23(2):144–150

    CAS  PubMed  Google Scholar 

  • Najavits LM, Schmitz M, Gotthardt S, Weiss RD (2005) Seeking safety plus exposure therapy: an outcome study on dual diagnosis men. J Psychoactive Drugs 37(4):425–435

    Article  PubMed  Google Scholar 

  • Neylan TC, Lenoci M, Samuelson KW, Metzler TJ, Henn-Haase C, Hierholzer RW, Lindley SE, Otte C, Schoenfeld FB, Yesavage JA, Marmar CR (2006) No improvement of posttraumatic stress disorder symptoms with guanfacine treatment. Am J Psychiatr 163(12):2186–2188

    Article  PubMed  Google Scholar 

  • Noordsy DL, Schwab B, Fox L, Drake RE (1996) The role of self-help programs in the rehabilitation of persons with severe mental illness and substance use disorders. Community Ment Health J 32(1):71–81

    Article  CAS  PubMed  Google Scholar 

  • Norman SB, Wilkins KC, Tapert SF, Lang AJ, Najavits LM (2010) A pilot study of seeking safety therapy with OEF/OIF veterans. J Psychoactive Drugs 42(1):83–87

    Article  PubMed  PubMed Central  Google Scholar 

  • Norquist GS, Hough RL, Golding JM, Escobar JI (1990) Psychiatric disorder in male veterans and nonveterans. J Nerv Ment Dis 178(5):328–335

    Article  CAS  PubMed  Google Scholar 

  • Nunes EV, Quitkin FM, Donovan SJ, Deliyannides D, Ocepek-Welikson K, Koenig T, Brady R, McGrath PJ, Woody G (1998) Imipramine treatment of opiate-dependent patients with depressive disorders: a placebo-controlled trial. Arch Gen Psychiatry 55(2):153–160

    Article  CAS  PubMed  Google Scholar 

  • Nuttbrock LA, Rahav M, Rivera JJ, Ng-Mak DS, Link BG (1998) Outcomes of homeless mentally ill chemical abusers in community residences and a therapeutic community. Psychiatr Serv 49(1):68–76

    Article  CAS  PubMed  Google Scholar 

  • O’Connell MJ, Kasprow W, Rosenheck R (2009) Direct placement versus multistage models of supported housing in a population of veterans who are homeless. Psychol Serv 6(3):190

    Article  Google Scholar 

  • O’Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 49(11):881–887

    Article  PubMed  Google Scholar 

  • Pacini M, Maremmani I (2005) Methadone reduces the need for antipsychotic and antimanic agents in heroin addicts hospitalized for manic and/or acute psychotic episodes. Heroin Addict Relat Clin Probl 7(4):43–48

    Google Scholar 

  • Pepper B, Kirshner MC, Ryglewicz H (1981) The young adult chronic patient: overview of a population. Hosp Community Psychiatry 32(7):463–469

    CAS  PubMed  Google Scholar 

  • Pepper B, Ryglewicz H, Kirshner MC (1982) The uninstitutionalized generation: a new breed of psychiatric patient. New Dir Ment Health Serv 1982(14):3–14

    Article  Google Scholar 

  • Petrakis IL, Leslie D, Rosenheck R (2003a) The use of antidepressants in alcohol-dependent veterans. J Clin Psychiatry 64(8):865–870

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, Leslie D, Rosenheck R (2003b) Use of naltrexone in the treatment of alcoholism nationally in the Department of Veterans Affairs. Alcohol Clin Exp Res 27(11):1780–1784

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal JH (2004) Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 172(3):291–297

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B (2005) Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 57(10):1128–1137

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, Leslie D, Finney JW, Rosenheck R (2006a) Atypical antipsychotic medication and substance use-related outcomes in the treatment of schizophrenia. Am J Addict 15(1):44–49

    Article  PubMed  Google Scholar 

  • Petrakis IL, Nich C, Ralevski E (2006b) Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram. Schizophr Bull 32(4):644–654

    Article  PubMed  PubMed Central  Google Scholar 

  • Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, Rounsaville B (2006c) Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Biol Psychiatry 60(7):777–783

    Article  CAS  PubMed  Google Scholar 

  • Petrakis IL, Rosenheck R, Desai R (2011) Substance use comorbidity among veterans with posttraumatic stress disorder and other psychiatric illness. Am J Addict 20(3):185–189

    Article  PubMed  Google Scholar 

  • Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH (2012) Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology 37(4):996–1004

    Article  CAS  PubMed  Google Scholar 

  • Petry NM (2000) A comprehensive guide to the application of contingency management procedures in clinical settings. Drug Alcohol Depend 58(1):9–25

    Article  CAS  PubMed  Google Scholar 

  • Pfefferbaum B (1997) Posttraumatic stress disorder in children: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 36(11):1503–1511

    CAS  PubMed  Google Scholar 

  • Picciotto MR, Brunzell DH, Caldarone BJ (2002) Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport 13(9):1097–1106

    Article  CAS  PubMed  Google Scholar 

  • Radhakrishnan R, Wilkinson ST, D’Souza DC (2014) Gone to pot–a review of the association between cannabis and psychosis. Front Psychol 5:54

    Google Scholar 

  • Ralevski E, O’Brien E, Jane JS, Dean E, Dwan R, Petrakis I (2011) Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence. J Nerv Ment Dis 199(7):499–505

    Article  PubMed  Google Scholar 

  • Ralevski E, Gianoli MO, Russo M, Dwan R, Radhakrishnan R (2012) Cognitive deficits in schizophrenia and alcoholism: a review of the evidence and findings on the effects of treatment on cognitive functioning in patients with dual diagnoses. J Dual Diagn 8(3):205–217

    Article  Google Scholar 

  • Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, Shofer J, O’Connell J, Taylor F, Gross C (2007) A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry 61(8):928–934

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen DD, Alexander LL, Raskind MA, Froehlich JC (2009) The α1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res 33(2):264–272

    Article  CAS  PubMed  Google Scholar 

  • Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK (1990) Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. JAMA 264(19):2511–2518

    Article  CAS  PubMed  Google Scholar 

  • Resnick SG, Rosenheck RA (2008) Posttraumatic stress disorder and employment in veterans participating in Veterans Health Administration compensated work therapy. J Rehabil Res Dev 45(3):427–435

    Article  PubMed  Google Scholar 

  • Ries RK, Dyck DG, Short R, Srebnik D, Fisher A, Comtois KA (2004) Outcomes of managing disability benefits among patients with substance dependence and severe mental illness. Psychiatr Serv 55(4):445–447

    Article  PubMed  Google Scholar 

  • Rosen CS, Kuhn E, Greenbaum MA, Drescher KD (2008) Substance abuse–related mortality among middle-aged male VA psychiatric patients. Psychiatr Serv 59(3):290–296

    Article  PubMed  Google Scholar 

  • Rosen MI, Carroll KM, Stefanovics E, Rosenheck RA (2009) A randomized controlled trial of a money management–based substance use intervention. Psychiatr Serv (Washington, DC) 60(4):498

    Article  Google Scholar 

  • Rosenheck R, Director V (n.d.) Appendix C, mental and substance-use health services for veterans: experience with performance evaluation in the Department of Veterans Affairs. Improving the quality of health care for mental and substance-use conditions: quality chasm series, p 423–482

    Google Scholar 

  • Rosenheck R, Fontana A (1996) Race and outcome of treatment for veterans suffering from PTSD. J Trauma Stress 9(2):343–351

    Article  CAS  PubMed  Google Scholar 

  • Rosenheck RA, Banks S, Pandiani J, Hoff R (2000) Bed closures and incarceration rates among users of Veterans Affairs mental health services. Psychiatr Serv 51(10):1282–1287

    Article  CAS  PubMed  Google Scholar 

  • Rosenheck R, Kasprow W, Frisman L, Liu-Mares W (2003) Cost-effectiveness of supported housing for homeless persons with mental illness. Arch Gen Psychiatry 60(9):940–951

    Article  PubMed  Google Scholar 

  • Sarnyai Z, Bíró É, Gardi J, Vecsernyés M, Julesz J, Telegdy G (1995) Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats. Brain Res 675(1):89–97

    Article  CAS  PubMed  Google Scholar 

  • Schimmelmann BG, Conus P, Cotton SM, Kupferschmid S, Karow A, Schultze-Lutter F, McGorry PD, Lambert M (2011) Cannabis use disorder and age at onset of psychosis—a study in first-episode patients. Schizophr Res 129(1):52–56

    Article  PubMed  Google Scholar 

  • Schneider U, Wohlfarth K, Schulze-Bonhage A, Haacker T, Müller-Vahl K, Zedler M, Becker H, Dengler R, Emrich H (1999) Effects of acamprosate on memory in healthy young subjects. J Stud Alcohol Drugs 60(2):172

    Article  CAS  Google Scholar 

  • Sekerka R, Goldsmith RJ, Brandewie L, Somoza E (1999) Treatment outcome of an outpatient treatment program for dually-diagnosed veterans: the Cincinnati Veterans Affairs Medical Center. J Psychoactive Drugs 31(1):85–94

    Article  CAS  PubMed  Google Scholar 

  • Sernyak MJ, Glazer WM, Heninger GR, Charney DS, Woods SW, Petrakis IL, Krystal JH, Price LH (1998) Naltrexone augmentation of neuroleptics in schizophrenia. J Clin Psychopharmacol 18(3):248–251

    Article  CAS  PubMed  Google Scholar 

  • Sigmon SC, Steingard S, Badger GJ, Anthony SL, Higgins ST (2000) Contingent reinforcement of marijuana abstinence among individuals with serious mental illness: a feasibility study. Exp Clin Psychopharmacol 8(4):509

    Article  CAS  PubMed  Google Scholar 

  • Simpson TL, Saxon AJ, Meredith CW, Malte CA, McBride B, Ferguson LC, Gross CA, Hart KL, Raskind M (2009) A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcohol Clin Exp Res 33(2):255–263

    Article  CAS  PubMed  Google Scholar 

  • Southwick SM, Bremner JD, Rasmusson A, Morgan CA, Arnsten A, Charney DS (1999) Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 46(9):1192–1204

    Article  CAS  PubMed  Google Scholar 

  • Swerdlow NR, Britton KT, Koob GF (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 2(4):285–292

    Article  CAS  PubMed  Google Scholar 

  • Tanaka T, Yokoo H, Mizoguchi K, Yoshida M, Tsuda A, Tanaka M (1991) Noradrenaline release in the rat amygdala is increased by stress: studies with intracerebral microdialysis. Brain Res 544(1):174–176

    Article  CAS  PubMed  Google Scholar 

  • Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA (2008) Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry 63(6):629–632

    Article  CAS  PubMed  Google Scholar 

  • Tejani N, Rosenheck R, Tsai J, Kasprow W, McGuire J (2014) Incarceration histories of homeless veterans and progression through a national supported housing program. Community Ment Health J 50(5):514–519

    Article  CAS  PubMed  Google Scholar 

  • Tinetti ME, Fried TR, Boyd CM (2012) Designing health care for the most common chronic condition—multimorbidity. JAMA 307(23):2493–2494

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Titievsky J, Seco G, Barranco M, Kyle EM (1982) Doxepin as adjunctive therapy for depressed methadone maintenance patients: a double-blind study. J Clin Psychiatry 43(11):454–456

    CAS  PubMed  Google Scholar 

  • Torrens M, Fonseca F, Mateu G, Farré M (2005) Efficacy of antidepressants in substance use disorders with and without comorbid depression: a systematic review and meta-analysis. Drug Alcohol Depend 78(1):1–22

    Article  CAS  PubMed  Google Scholar 

  • Tsai J, Kasprow WJ, Rosenheck RA (2014) Alcohol and drug use disorders among homeless veterans: prevalence and association with supported housing outcomes. Addict Behav 39(2):455–460

    Article  PubMed  Google Scholar 

  • Volpicelli JR, Alterman AI, Hayashida M, O’Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49(11):876–880

    Article  CAS  PubMed  Google Scholar 

  • Voruganti L, Awad A (2004) Neuroleptic dysphoria: towards a new synthesis. Psychopharmacology 171(2):121–132

    Article  CAS  PubMed  Google Scholar 

  • Wieder H, Kaplan EH (1968) Drug use in adolescents. Psychodynamic meaning and pharmacogenic effect. Psychoanal Study Child 24:399–431

    Article  Google Scholar 

  • Woody GE, O’Brien CP, Rickels K (1975) Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone. Am J Psychiatry 132(4):447–450

    Article  CAS  PubMed  Google Scholar 

  • Ziedonis D, Richardson T, Lee E, Petrakis I, Kosten T (1992) Adjunctive desipramine in the treatment of cocaine abusing schizophrenics. Psychopharmacol Bull 28(3):309–314

    CAS  PubMed  Google Scholar 

  • Zimmet SV, Strous RD, Burgess ES, Kohnstamm S, Green AI (2000) Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. J Clin Psychopharmacol 20(1):94–98

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert A. Rosenheck .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Science+Business Media, LLC

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jorandby-Quinones, L., Edens, E., Rosenheck, R.A. (2018). Co-occurring Substance and Mental Health Disorders. In: Roberts, L., Warner, C. (eds) Military and Veteran Mental Health. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7438-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-7438-2_20

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7436-8

  • Online ISBN: 978-1-4939-7438-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics