Abstract
Fluidized bed processing of multiparticulate is a common technology used in the pharmaceutical industry. It is used for drug layering onto an inert core material, seal coating of drug containing cores, and the final functional coating. The fluid bed technology has evolved in various configurations, based on a top spray, bottom spray, or tangential spray. No matter which configuration is used, it is characterized by a very random and rapid mixing capability of the multiparticulate substrates. Various functional film coatings may be applied using aqueous of solvent media. The key properties of substrate, coating material, and process variables involved in fluid bed and their influence on product quality are discussed in this chapter.
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Jones, D.M., Rajabi-Siahboomi, A.R. (2017). Fluid Bed Technology, Process Robustness, and Scale-Up. In: Rajabi-Siahboomi, A. (eds) Multiparticulate Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7012-4_4
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DOI: https://doi.org/10.1007/978-1-4939-7012-4_4
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