Abstract
Hard gelatin capsules have been used for centuries; however, there is a recent growing interest in capsules for their applications in novel drug delivery systems and achieving control of drug release profiles.
Hard shell capsules offer a significant amount of flexibility for the administration of multiparticulates and for the combination of different drugs within the same solid dosage unit, in terms of filling technologies and machine configurations, while at the same time ensuring a robust and reproducible process. In addition, a wide range of systems have recently been developed to achieve an in-line check and control of the capsule weight, even in the case of product combinations.
This chapter provides an overview of the current criteria and processing considerations, challenges, options, and opportunities of encapsulating (in hard shell capsules) of multiparticulates.
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Lipp R. Major advances in oral drug delivery over the past 15 years. American pharmaceutical review. 2013. http://www.americanpharmaceuticalreview.com/Featured-Articles/148747-Major-Advances-in-Oral-Drug-Delivery-over-the-Past-15-Years.
IMS Institute. Advancing the responsible use of medicines. October: Applying levers for a change; 2012.
Gupta A, Udupa N, Sreedhar D. Fixed-dose combinations. Pharm Technol. 2012;24:1–4.
Rowe RC, York P, Colbourn EA, Roskilly SJ. The influence of pellet shape, size and distribution on capsule filling; three dimensional computer simulation using a Monte-Carlo technique. Int J Pharm. 2005;300(1–2):32–7.
Keerthi ML, Shireesh Kiran R, Uma Maheshwar Rao V, Sannapu A, Dutt AG, Krishna KS. Pharmaceutical mini-tablets, its advantages, formulation possibilities and general evaluation aspects: a review. Int J Pharm Sci Rev Res. 2014;28(1):214–21.
C. Funaro, G. Mondelli, N. Passerini, B. Albertini. Mini-tablets coated in a solid-wall pan for theophylline sustained-release capsules. Pharm Tech Drug Delivery. 2010:38–42.
Rouge N, Allémann E, Gex-Fabry M. Comparative pharmacokinetic study of a floating multiple unit capsule, a high density multiple unit capsule and an immediate release tablet containing 25 mg atenolol. Pharm Acta Helv. 1998;73:81–7.
Tehseen N, Rao V, Hadi MA. Design and characterization of twice daily mini-tablets formulation of pregabalin. Int J Pharm Pharm Sci. 2013;5(1):168–75.
Podczeck F, Jones BE, editors. Pharmaceutical capsule. 2nd ed. London/Chicago: Pharmaceutical Press; 2004. p. 101–18.
Wade A, Weller P. Gelatin, handbook of pharmaceutical excipients. 2nd ed. London: Pharmaceutical Press; 1994. p. 199–201.
Stegemann S. Hard gelatin capsules today and tomorrow, 2nd ed. Capsugel Library; 2002. www.capsugel.com.
Cole ET, Scott RA, Connor AL, Wilding IR, Petereit HU, Schminke C, Beckert T, Cadé D. Enteric coated HPMC capsules designed to achieve intestinal targeting. Int J Pharm. 2002;231(1):83–95.
Kumar KK, Babu ND, Pasupathi A. Design and evaluation of multiparticulate system of extended release indomethacin capsules USP. Res J Pharm, Biol Chem Sci. 2010;1(4):74–82.
Reddy BV, Babu GD, Premswaroop A, Sekhar MC, Ramya Y. Formulation development and evaluation of extended release mini-tablets of Risperidone. J Pharm Sci Innovation. 2012;1(1):33–7.
Dinesh P, Sajeeth CI, Sirwani R, Santhi K. Modulation of Combined Release Behaviors from a novel pellets and mini-tablet in capsule system. Int J Res Pharmaceut Biomed Sci. 2011;2(2):649–60.
Ishida M, Abe K, Hashizume M, Kawamura M. A novel approach to sustained pseudoephedrine release: differentially coated mini-tablets in HPMC capsules. Int J Pharm. 2008;359:1–2. 46–52
Greyser SA. Johnson & Johnson: the Tylenol tragedy, Harvard Business School case 583–043, 1982 (revised May 1992). http://www.hbs.edu/faculty/Pages/item.aspx?num=17858.
Code of Federal Regulations, Title 21, Volume 4, Revised as of April 1, 2013 CITE: 21CFR211.132.
Brown S, Bowtle B. Advances in capsule technology for pharmaceuticals and nutraceuticals, Nutraceutical Business & Technology, 2007, Nov. issue, http://www.thefreelibrary.com/Advances+in+capsule+technology+for+pharmaceuticals+and+nutraceuticals.-a0199464919.
Thoma K, Bechtold K. Enteric coated hard gelatin capsules. Capsugel Library. 1992. www.capsugel.com.
US FDA. Guidance for industry: PAT a framework for innovative pharmaceutical manufacturing and quality assurance. Rockville: FDA; 2004.
Macchina dosatrice Mod. G120/NETT”, Notiziario Chimico Farmaceutico N° 9, 1998, November issue, 52–53.
Armstrong N. Chapter 10, The instrumentation of capsule filling machinery. In: Ridgeway P, Armstrong N, editors. Tablet and capsule machine instrumentation. London/Chicago: Pharmaceutical Press; 2008.
Vogt M, Beck M, Maga I. 100 % On-line Quality Control with X-Ray-Technology. TechnoPharm. 2011;1(1):60–7.
On line MG2 Brochure: http://www.mg2.it/process/SiteAssets/Lists/WCSModels/NewForm/NETT_%20227219_rev_10_03.pdf – accessed May 2016.
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Bertuzzi, G., Barzanti, S. (2017). Filling of Hard Shell Capsules and Packaging Aspects of Multiparticulate Systems. In: Rajabi-Siahboomi, A. (eds) Multiparticulate Drug Delivery. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7012-4_13
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DOI: https://doi.org/10.1007/978-1-4939-7012-4_13
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