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Invasive Carcinoma

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Atlas of Differential Diagnosis in Breast Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

Most breast malignancies arise from epithelial cells of terminal ductal lobular units and are categorised as carcinomas. Invasive or infiltrative carcinoma refers to a proliferation of neoplastic cells with penetration through the basement membrane of ducts and lobular units into the breast stroma. Breast carcinoma, although often discussed as a single disease, actually constitutes a diverse group of tumours that differ in clinical presentation, imaging features, histopathologic appearance, expression of biologic markers, and clinical behaviour. Several histological subtypes of invasive breast carcinoma have been recognised based on a wide range of criteria, including cell type, architectural features, type and location of secretions, and biomarker profiles. The WHO classification of breast tumours recognises 21 different histologic types of breast cancer with distinct morphologic features.

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  1. Division of Pathology, Singapore General Hospital, Singapore, Singapore

    Puay Hoon Tan

  2. The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA

    Aysegul A. Sahin

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Tan, P.H., Sahin, A.A. (2017). Invasive Carcinoma. In: Atlas of Differential Diagnosis in Breast Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6697-4_12

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