Abstract
Acrylamide (AA) (CAS number 79-06-1) (CH2=CH–CO–NH2), a white, odorless, toxic crystalline compound is produced mainly for the synthesis of nontoxic polyacrylamide, which is used as a flocculent in water treatment, and as a binder in pulp and paper processing. AA affects the nervous system even at low levels, causing hallucinations and drowsiness (IARC 1994). Human health effects associated with consumption of small amounts of AA over long periods of time are not known (Bent et al. 2012). AA vapors irritate the eyes and skin and cause paralysis of the cerebrospinal system (Kotsiou et al. 2011). Chronic exposure results in neurotoxicity in animals and humans, and AA has been found to be carcinogenic to laboratory animals. As a result, AA has been classified as “probably carcinogenic to humans” (Group 2A) by the International Agency for Research on Cancer (IARC 1994).
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References
Amrein T, Schönbächler B, Escher F, Amadò R (2004) Acrylamide in gingerbread: critical factors for formation and possible ways for reduction. J Agric Food Chem 52:4282–4288
Aziz A (2004) Reduction of acrylamide formation in cooked starchy foods. US 20040086597 A1
Baardseth P, Blom H, Enersen G, Skrede G, Slinde E, Sundt T, Thomassen T (2004) Reduction of acrylamide formation in cereal-based food processing. WO200i 28276 A2
Bagdonaite K, Derler K, Murkovic M (2008) Determination of Acrylamide during Roasting of Coffee. J Agric Food Chem 56:6081–6086
Banchero M, Pellegrino G, Manna L (2013) Supercritical fluid extraction as a potential mitigation strategy for the reduction of acrylamide level in coffee. J Food Eng 115:292–297
Bassama J, Brat P, Boulanger R, Gunata Z, Bohuon P (2012) Modeling deep-fat frying for control of acrylamide reaction in plantain. J Food Eng 113(1):156–166
Becalski A, Lau BPY, Lewis D, Seaman SW (2003) Acrylamide in foods: occurrence, sources, and modeling. J Agric Food Chem 51:802–808
Becalski A, Lau BPY, Lewis D, Seaman SW, Hayward S, Sahagian M et al (2004) Acrylamide in French fries: influence of free amino acids and sugars. J Agric Food Chem 52:3801–3806
Bent G, Maragh P, Dasgupta T (2012) Acrylamide in Caribbean foods – residual levels and their relation to reducing sugar and asparagine content. Food Chem 133:451–457
Biedermann M, Biedermann-Brem S, Noti A, Grob K (2002) Methods for determining the potential of acrylamide formation and its elimination in raw materials for food preparation, such as potatoes. Mitt Lebensmittelunters Hyg 93:653–667
Blank I, Robert F, Goldmann T, Pollien P, Varga N, Devaud S, Saucy F, Huynh-Ba T, Stadler R (2005) Mechanisms of acrylamide formation – maillard-induced transformation of asparagine. In: Friedman M, Mottram D (eds) Chemistry and safety of acrylamide in food, 561st edn. Springer, New York, NY, pp 171–189
Borrelli R, Fogliano V (2005) Bread crust melanoidins as potential prebiotic ingredients. Mol Nutr Food Res 49:673–678
Brathen E, Knutsen SH (2005) Effect of temperature and time on the formation of acrylamide in starch-based and cereal model systems, flat breads and bread. Food Chem 92:693–700
Budolfsen G, Jensen M, Heldt-Hansen HP, Stringer MA (2008) Asparaginases and method of preparing a heat-treated product. US7396670.
Califano A, Calvelo A (1987) Adjustment of surface concentration of reducing sugars before frying of potato strips. J Food Process Preserv 12:1–9
Capuano E, Fogliano V (2011) Acrylamide and 5-hydroxymethylfurfural (HMF): a review on metabolism, toxicity, occurrence in food and mitigation strategies. Lebensmittel-Wissenschaft und-Technologie 44:793–810
Chen YH, Xia EQ, Xu XR, Ling WH, Li S, Wu S, Deng GF, Zou ZF, Zhou J, Li HB (2012) Evaluation of acrylamide in food from China by a LC/MS/MS method. Int J Environ Res Public Health 9(11):4150–4158
Claeys W, De Vleeschouwer K, Hendrickx M (2005) Effect of amino acids on acrylamide formation and elimination kinetics. Biotechnology 21:1525–1530
Claus A, Carle R, Schieber A (2008) Acrylamide in cereal products: a review. J Cereal Sci 47:118–133
Corrigan P (2005) Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce. US20050079254
De Vleeschouwer K, Plancken I, Van Loey A, Hendrickx M (2007) Kinetics of acrylamide formation/elimination reactions as affected by water activity. Biotechnol Prog 2:722–728
EC (2006) European Union Acrylamide Monitoring Database. Available at: http://irmm.jrc.ec.europa.eu/activities/acrylamide/Pages/database.aspx
EFSA (2011) Scientific report of EFSA - results on acrylamide levels in food from monitoring years 2007-2009 and exposure assessment. EFSA J 9:2133
Elder V, Fulcher J, Leung H (2006) Method for reducing acrylamide formation in thermally processed foods. US20060127534
FDA (2006) Survey data on acrylamide in food: individual food products. Available at: http://www.fda.gov/Food/FoodSafety/FoodContaminantsAdulteration/ChemicalContaminants/acrylamide/ucm053549.html
Friedman M, Levin CE (2008) Review of methods for the reduction of dietary contents and toxicity of acrylamide. J Agric Food Chem 56:6113–6140
Gerenda SJ, Heuser F, Sattelmacher B (2007) Influence of nitrogen and potassium supply on contents of acrylamide precursors in potato tubers and on acrylamide accumulation in French fries. J Plant Nutr 30:1499–1516
Gertz C, Klostermann S (2002) Analysis of acrylamide and mechanisms of its formation in deep fried products. Eur J Lipid Sci Technol 104:762–771
Gökmen V, Palazoglu TK (2008) Acrylamide formation in foods during thermal processing with a focus on frying. Food Bioprocess Technol 1:35–42
Gökmen V, Senyuva HZ (2006) A simplified approach for the kinetic characterization of acrylamide formation in fructose-asparagine model system. Food Addit Contam 23(4):348–354
Granda C, Moreira R, Tichy SE (2004) Reduction of acrylamide formation in potato chips by low-temperature vacuum frying. J Food Sci 68:405–411
Granvogl M, Schieberle P (2006) Thermally generated 3-amminopropionammide as a transient intermediate in the formation of acrylamide. J Agric Food Chem 54:5933–5938
Haase NU, Matthäus B, Vosmann K (2003) Minimierungsansätze zur Acrylamid-Bildung in pflanzlichen Lebensmitteln-aufgezeigt am Beispiel von Kartoffelchips. Dtsch Lebensmitt Rundsch 99:87–90
Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA (2007) A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Cancer Epidemiol Biomarkers Prev 16:2304–2313
Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA (2008) Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr 87:1428–1438
Hogervorst JGF, Schouten LJ, Konings EJM, Goldbohm RA, van den Brandt PA (2009) Lung cancer risk in relation to dietary acrylamide intake. J Natl Cancer Inst 101:651–662
IARC (International Agency for Research on Cancer) (1994) Acrylamide. IARC Monogr Eval Carcinog Risks Hum 60:389
Jung MY, Choi DS, Ju JW (2003) A novel technique for limitation of acrylamide formation in fried and baked corn chips and in French fries. J Food Sci 68:1287–1290
Kim C, Eun-Sun H, Lee H (2005) Reducing acrylamide in fried snack products by adding amino acids. J Food Sci 70:C354–C358
Kolek E, Simko P, Simon P (2006) Inhibition of acrylamide formation in asparagine/D-glucose model system by NaCl addition. Eur Food Res Tech 224:283–284
Kotsiou K, Tasioula-Margari M, Capuano E, Fogliano V (2011) Effect of standard phenolic compounds and olive oil phenolic extracts on acrylamide formation in an emulsion system. Food Chem 124:242–247
Lindermeier M, Hofmann T (2004) Influence of baking conditions and precursor supplementation on the amounts of the antioxidant pronyl-L-lysine in bakery products. J Agric Food Chem 52:350–354
Lindsay R, Jang S (2005a) Chemical intervention strategies for substantial suppression of acrylamide formation in fried potato products. In: Friedman M, Mottram D (eds) Chemistry and safety of acrylamide in food. Springer, New York, NY, pp 393–404
Lindsay RC, Jang SJ (2005b) Chemical intervention strategies for substantial suppression of acrylamide formation in fried potato products. Adv Exp Med Biol 561:393–404
Lineback D, Wenzl T, Ostermann O, DeLaCalle B, Anklam E, Taeymans D (2005) Overview of acrylamide monitoring databases. J AOAC Int 88:246–252
Lineback D, Coughlin JR, Stadler RH (2012) Acrylamide in foods: a review of the science and future considerations. Annu Rev Food Sci Technol 3:15–35
Mariotti S, Pedreschi F, Carrasco J, Granby K (2011) Patented techniques for acrylamide mitigation in high-temperature processed foods. Recent Pat Food Nutr Agric 2011(3):158–171
Medeiros R, Mestdagh F, De Meulanaer B (2012) Acrylamide formation in fried potato products – present and future, a critical review on mitigation strategies. Food Chem 133:1138–1154
Mottram DS, Wedzicha BL, Dodson A (2002) Acrylamide is formed in the Maillard reaction. Nature 419:448–449
Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K (2003) Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer 88(1):84–89
Muttucumaru N, Halford NG, Elmore JS, Dodson AT, Parry M, Shewry PR (2006) Formation of high levels of acrylamide during the processing of flour derived from sulfate-deprived wheat derived from sulfate-deprived wheat. J Agric Food Chem 54:8951–8955
Oku K, Kurose M, Ogawa T, Kubota M, Chaen H, Fukuda S, Tsujisaka Y (2005) Suppressive effect of trehalose on acrylamide formation form asparagine and reducing saccharides. Biosci Biotech Biochem 69:1520–1526
Pedreschi F (2012) Frying of potatoes: physical, chemical, and microstructural changes. Dry Technol 30:707–725
Pedreschi F, Kaack K, Granby K (2004) Reduction of acrylamide formation in potato slices during frying. Lebensmittel-Wissenschaft und-Technologie 37:679–685
Pedreschi F, Kaack K, Granby K, Troncoso E (2007) Acrylamide reduction under different pre-treatments in French fries. J Food Eng 79:1287–1294
Pedreschi F, Segtnan VH, Knutsen SH (2010) On-line monitoring of fat, dry matter and acrylamide contents in potato chips using near infrared interactance and visual reflectance imaging. Food Chem 121:616–620
Pedreschi F, Mariotti M, Kit G, Risum J (2011) Acrylamide diminishing in potato chips by using commercial asparaginase in combination with conventional blanching. Lebensmittel-Wissenschaft und-Technologie 44:1473–1476
Pedreschi F, Bunger A, Skurtys O, Allen P, Rojas X (2012) Grading of potato chips according to their sensory quality determined by color. Food Bioprocess Tech 5:2401–2408
Perez-Locas C, Yaylayan VA (2008) Isotope labeling studies on the formation of 5-(hydroxymethyl)-2-furaldehyde (HMF) from sucrose by pyrolysis-GC/MS. J Agric Food Chem 56:6717–6723
Rommens CM, Ye J, Richael C, Swords K (2007) K Improving potato storage and processing characteristics through all-native DNA transformation. J Agric Food Chem 54:9882–9887
Rosén J, Hellenäs KE (2002) Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry. Analyst 127:880–882
Rydberg P, Eriksson S, Tareke E, Karlsson P, Ehrenberg L, Tornqvist M (2003) Investigations of factors that influence the acrylamide content of heated foodstuffs. J Agric Food Chem 51:7012–7018
Schouten L, Hogervorst J, Konings E, Goldbohm R, van den Brandt P (2009) Dietary acrylamide intake and the risk of head-neck and thyroid cancers: results from the Netherlands Cohort Study. Am J Epidemiol 170:873–884
Smith E, Oehme F (1991) Acrylamide and polyacrylamide: a review of production, use, environmental fate and neurotoxicity. Rev Environ Health 9:215–228
Stadler R, Scholz G (2004) Acrylamide: an update on current knowledge in analysis, levels in food, mechanisms of formation, and potential strategies of control. Nutr Rev 62:449–467
Stadler RH, Blank I, Varga N, Robert F, Hau J, Guy A, Robert P, Riediker MC (2002) Acrylamide from Maillard reaction products. Nature 419:449–450
Stadler R, Robert F, Riediker S, Varga N, Davidek T, Devaud S, Goldmann T, Blank I (2004) In-depth mechanistic study on the formation of acrylamide and other vinylogous compounds by the Maillard reaction. J Agric Food Chem 52:5550–5558
Taeymans D, Wood J, Ashby P, Blank I, Studer A, Stadler R, Gonde P, Van Eijck P, Lalljie S, Lingert H, Lindblom M, Matisek R, Muller D, O’Brien J, Thompson S, Silvani D, Whitmore T (2004) A review of acrylamide: an industry perspective on research, analysis, formation, and control. Crit Rev Food Sci Nutr 44:323–347
Tareke E, Rydberg P, Karlsson P, Eriksson S, Tornqvist M (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 50:4998–5006
Van Boekel M, Fogliano V, Pellegrini N, Stanton C, Scholz G, Lalljie S, Somoza V, Knorr D, Jasti P, Eisenbrand G (2010) A review on the beneficial aspects of food processing. Mol Nutr Food Res 54:1215–1247
Vattem DA, Shetty K (2003) Acrylamide in food: a model for mechanism of formation and its reduction. Innov Food Sci Emerg Technol 4:331–338
Wilson K, Mucci L, Rosner B, Willet W (2010) A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. Cancer Epidemiol Biomarkers Prev 19:2503–2515
Yaylayan VA, Wnorowski A, Pérez Locas C (2003) Why asparagine needs carbohydrates to generate acrylamide? J Agric Food Chem 51:1753–1757
Zhang Y, Zhang Y (2007) Formation and reduction of acrylamide in Maillard reaction: a review based on the current state of knowledge. Crit Rev Food Sci Nutr 47:521–542
Zyzak D, Sanders RA, Stojanovic M, Tallmadge DH, Ebehart L, Ewald DK, Gruber DC, Morsch TR, Strothers MA, Rizzi GP, Villagran MD (2003) Acrylamide formation mechanism in heated foods. J Agric Food Chem 51:4782–4787
Zyzak V, Sanders R, Stojanovic M, Gruber D, Yau Tak Lin P, Martínez-Serna MD, Howie J, Schafermeyer R (2004) Method for reducing acrylamide in foods, foods having reduced levels of acrylamide, and article of commerce. US20040058046
Acknowledgments
The authors acknowledge financial support from the FONDECYT Project No 1110510. I appreciate the collaboration in the designing of the structure of this book chapter of Farina Galvez.
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Pedreschi, F., Mariotti, M.S. (2017). Mitigation of Acrylamide Formation in Highly Consumed Foods. In: Barbosa-Cánovas, G., et al. Global Food Security and Wellness. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6496-3_19
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