Abstract
Somatic sensation comprises four main modalities relaying tactile, thermal, painful, or pruritic (itch) information to the central nervous system. These input channels can be further classified as sub-serving sensory functions, such as spatial and temporal discrimination, and the provision of essential information for controlling and guiding exploratory manual behaviours, or affective functions that include the provision of the subjective experience of affective or emotional pleasurable touch. Signalling in fast-conducting myelinated peripheral nerve fibres (Aβ afferents) is important for the discriminative properties of tactile sensations, whereas signalling in unmyelinated peripheral nerve fibres, C-tactile (CT) afferents seems to be important for the rewarding, emotional properties of touch. CT afferents have specific biophysical, electrophysiological, neurobiological and anatomical properties to drive the temporally delayed affective somatic system. This chapter explores step by step the differences between the discriminative and affective touch systems, from the first stage of encoding touch in the skin to the neural pathways in the brain. The below quote from Bentley (Am J Psychol 11:405–425, 1900) reiterates the complexity of the skin and the wonder in the phenomenon of somatosensation:
‘The skin is burdened with offices. One of the surprises of physiology is the revelation of the multitude of functions performed by this apparently simple organ. As a rind it is not only the container, but the warder-off, and also the go-between for the organism and its world; tegument, buckler, interagent. It is small wonder that its work is represented in mental process; that many of our most worn and useful perceptions are made up of cutaneous sensations.’
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Abraira VE, Ginty DD (2013) The sensory neurons of touch. Neuron 79:618–639. doi:10.1016/j.neuron.2013.07.051
Ackerley R, Backlund Wasling H, Liljencrantz J et al (2014a) Human C-tactile afferents are tuned to the temperature of a skin-stroking caress. J Neurosci 34:2879–2883. doi:10.1523/JNEUROSCI.2847-13.2014
Ackerley R, Carlsson I, Wester H et al (2014b) Touch perceptions across skin sites: differences between sensitivity, direction discrimination and pleasantness. Front Behav Neurosci 8:54. doi:10.3389/fnbeh.2014.00054
Ackerley R, Eriksson E, Wessberg J (2013) Ultra-late EEG potential evoked by preferential activation of unmyelinated tactile afferents in human hairy skin. Neurosci Lett 535:62–66. doi:10.1016/j.neulet.2013.01.004
Ackerley R, Hassan E, Curran A et al (2012) An fMRI study on cortical responses during active self-touch and passive touch from others. Front Behav Neurosci 6:51. doi:10.3389/fnbeh.2012.00051
Ackerley R, Kavounoudias A (2015) The role of tactile afference in shaping motor behaviour and implications for prosthetic innovation. Neuropsychologia 79(Pt B):192–205. doi:10.1016/j.neuropsychologia.2015.06.024.
Ackerley R, Saar K, McGlone F, Backlund Wasling H (2014c) Quantifying the sensory and emotional perception of touch: differences between glabrous and hairy skin. Front Behav Neurosci 8:34. doi:10.3389/fnbeh.2014.00034
Adriaensen H, Gybels J, Handwerker H, Van Hees J (1983) Response properties of thin myelinated (A-delta) fibers in human skin nerves. J Neurophysiol 49:111–122
Adrian E, Umrath K (1929) The impulse discharge from the pacinian corpuscle. J Physiol 68:139–154. doi:10.1007/SpringerReference_183154
Andrew D (2010) Quantitative characterization of low-threshold mechanoreceptor inputs to lamina I spinoparabrachial neurons in the rat. J Physiol 588:117–124. doi:10.1113/jphysiol.2009.181511
Azañón E, Longo MR, Soto-Faraco S, Haggard P (2010) The posterior parietal cortex remaps touch into external space. Curr Biol 20:1304–1309. doi:10.1016/j.cub.2010.05.063
Bentley I (1900) The synthetic experiment. Am J Psychol 11:405–425
Birznieks I, Macefield VG, Westling G, Johansson RS (2009) Slowly adapting mechanoreceptors in the borders of the human fingernail encode fingertip forces. J Neurosci 29:9370–9379. doi:10.1523/JNEUROSCI.0143-09.2009
Bolognini N, Rossetti A, Convento S, Vallar G (2013) Understanding others’ feelings: the role of the right primary somatosensory cortex in encoding the affective valence of others’ touch. J Neurosci 33:4201–4205. doi:10.1523/JNEUROSCI.4498-12.2013
Bostock H, Campero M, Serra J, Ochoa J (2003) Velocity recovery cycles of C fibres innervating human skin. J Physiol 553:649–663. doi:10.1113/jphysiol.2003.046342
Brown A (1977) Cutaneous axons and sensory neurones in the spinal cord. Br Med Bull 33:109–112
Brown A, Fyffe R, Noble R (1980) Projections from Pacinian corpuscles and rapidly adapting mechanoreceptors of glabrous skin to the cat’s spinal cord. J Physiol 307:385–400
Büchel C, Geuter S, Sprenger C, Eippert F (2014) Placebo analgesia: a predictive coding perspective. Neuron 81:1223–1239. doi:10.1016/j.neuron.2014.02.042
Burgess PR, Petit D, Warren R (1968) Receptor types in cat hairy skin supplied by myelinated fibers. J Neurophysiol 31:833–848
Chambers M, Andres K, Duering M, Iggo A (1972) The structure and function of the slowly adapting type II mechanoreceptor in hairy skin. Q J Exp Physiol 57:417–445
Chikenji T, Berger RA, Fujimiya M et al (2011) Distribution of nerve endings in human distal interphalangeal joint and surrounding structures. J Hand Surg Am 36:406–412. doi:10.1016/j.jhsa.2010.11.050
Chikenji T, Suzuki D, Fujimiya M et al (2010) Distribution of nerve endings in the human proximal interphalangeal joint and surrounding structures. J Hand Surg Am 35:1286–1293. doi:10.1016/j.jhsa.2010.04.026
Cole J, Bushnell MC, McGlone F et al (2006) Unmyelinated tactile afferents underpin detection of low-force monofilaments. Muscle Nerve 34:105–107. doi:10.1002/mus.20534
Coleman GT, Bahramali H, Zhang HQ, Rowe MJ (2001) Characterization of tactile afferent fibers in the hand of the marmoset monkey. J Neurophysiol 85:1793–1804
Condon M, Birznieks I, Hudson K et al (2014) Differential sensitivity to surface compliance by tactile afferents in the human finger pad. J Neurophysiol 111:1308–1317. doi:10.1152/jn.00589.2013
Craig AD (2003) Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 13:500–505. doi:10.1016/S0959-4388(03)00090-4
Craig AD (2002) How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3:655–666. doi:10.1038/nrn894
Craig AD (2009) How do you feel--now? The anterior insula and human awareness. Nat Rev Neurosci 10:59–70. doi:10.1038/nrn2555
Douglas W, Ritchie J (1957) Non-medullated fibres in the saphenous nerve which signal touch. J Physiol 139:385–399
Driskell RR, Giangreco A, Jensen KB et al (2009) Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development 136:2815–2823. doi:10.1242/dev.038620
Edin BB (1992) Quantitative analysis of static strain sensitivity in human mechanoreceptors from hairy skin. J Neurophysiol 67:1105–1113
Essick GK, James A, McGlone FP (1999) Psychophysical assessment of the affective components of non-painful touch. Neuroreport 10:2083–2087
Essick GK, McGlone F, Dancer C et al (2010) Quantitative assessment of pleasant touch. Neurosci Biobehav Rev 34:192–203. doi:10.1016/j.neubiorev.2009.02.003
Francis S, Rolls ET, Bowtell R et al (1999) The representation of pleasant touch in the brain and its relationship with taste and olfactory areas. Neuroreport 10:453–459
Gairns F (1955) The sensory nerve endings of the human palate. Exp Physiol 40:40–48
Gazzola V, Spezio ML, Etzel JA et al (2012) Primary somatosensory cortex discriminates affective significance in social touch. Proc Natl Acad Sci U S A 109:E1657–E1666. doi:10.1073/pnas.1113211109
Gordon I, Voos AC, Bennett RH et al (2013) Brain mechanisms for processing affective touch. Hum Brain Mapp 34:914–922. doi:10.1002/hbm.21480
Guest S, Dessirier JM, Mehrabyan A et al (2011) The development and validation of sensory and emotional scales of touch perception. Atten Percept Psychophys 73:531–550. doi:10.3758/s13414-010-0037-y
Hagen MC, Pardo JV (2002) PET studies of somatosensory processing of light touch. Behav Brain Res 135:133–140
Halata Z (1993) Sensory innervation of the hairy skin (light- and electronmicroscopic study). J Invest Dermatol 101:75S–81S
Horch K, Tuckett R, Burgess P (1977) A key to the classification of cutaneous mechanoreceptors. J Invest Dermatol 69:75–82
Hsiao SS, Johnson KO, Twombly IA (1993) Roughness coding in the somatosensory system. Acta Psychol (Amst) 84:53–67
Hsiao SS, Lane J, Fitzgerald P (2002) Representation of orientation in the somatosensory system. Behav Brain Res 135:93–103
Hua Q-P, Zeng X-Z, Liu J-Y et al (2008) Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli. Cell Mol Neurobiol 28:57–70. doi:10.1007/s10571-007-9228-z
Iggo A (1960) Cutaneous mechanoreceptors with afferent C fibres. J Physiol 152:337–353
Iggo A, Kornhuber HH (1977) A quantitative study of C-mechanoreceptors in hairy skin of the cat. J Physiol 271:549–565
Iggo A, Ogawa H (1977) Correlative physiological and morphological studies of rapidly adapting mechanoreceptors in cat’s glabrous skin. J Physiol 266:275–296
Jaeger H (1944) Recherches histologiques sur les terminaisons nerveuses dans la peau normale des organes génitaux externs humains. Dermatology 90:49–74. doi:10.1159/000255731
Järvilehto T, Hämäläinen H, Soininen K (1981) Peripheral neural basis of tactile sensations in man: II. Characteristics of human mechanoreceptors in the hairy skin and correlations of their activity with tactile sensations. Brain Res 219:13–27
Johansson R, Trulsson M, Olsson KÅ, Westberg K-G (1988) Mechanoreceptor activity from the human face and oral mucosa. Exp Brain 72:204–208
Johansson RS (1978) Tactile sensibility in the human hand: receptive field characteristics of mechanoreceptive units in the glabrous skin area. J Physiol 281:101–125
Johansson RS, Birznieks I (2004) First spikes in ensembles of human tactile afferents code complex spatial fingertip events. Nat Neurosci 7:170–177. doi:10.1038/nn1177
Johansson RS, Flanagan JR (2009) Coding and use of tactile signals from the fingertips in object manipulation tasks. Nat Rev Neurosci 10:345–359. doi:10.1038/nrn2621
Johansson RS, Landström U, Lundström R (1982) Responses of mechanoreceptive afferent units in the glabrous skin of the human hand to sinusoidal skin displacements. Brain Res 244:17–25
Johansson RS, Vallbo AB (1979) Tactile sensibility in the human hand: relative and absolute densities of four types of mechanoreceptive units in glabrous skin. J Physiol 286:283–300
Johansson RS, Vallbo AB (1980) Spatial properties of the population of mechanoreceptive units in the glabrous skin of the human hand. Brain Res 184:353–366
Johansson RS, Vallbo AB, Westling G (1980) Thresholds of mechanosensitive afferents in the human hand as measured with von Frey hairs. Brain Res 184:343–351
Johnson RD, Halata Z (1991) Topography and ultrastructure of sensory nerve endings in the glans penis of the rat. J Comp Neurol 312:299–310. doi:10.1002/cne.903120212
Johnson RD, Kitchell RL (1987) Mechanoreceptor response to mechanical and thermal stimuli in the glans penis of the dog. J Neurophysiol 57:1813–1836
Jörntell H, Bengtsson F, Geborek P et al (2014) Segregation of tactile input features in neurons of the cuneate nucleus. Neuron 83:1444–1452. doi:10.1016/j.neuron.2014.07.038
Kaas J, Nelson R, Sur M et al (1979) Multiple representations of the body within the primary somatosensory cortex of primates. Science 204(4392):521–523
Kaas JH, Nelson RJ, Sur M et al (1984) The somatotopic organization of the ventroposterior thalamus of the squirrel monkey, Saimiri sciureus. J Comp Neurol 226:111–140. doi:10.1002/cne.902260109
Keysers C, Kaas JH, Gazzola V (2010) Somatosensation in social perception. Nat Rev Neurosci 11:417–428. doi:10.1038/nrn2833
Klöcker A, Arnould C, Penta M, Thonnard J-L (2012) Rasch-built measure of pleasant touch through active fingertip exploration. Front Neurorobot 6:5. doi:10.3389/fnbot.2012.00005
Kumazawa T, Perl ER (1977) Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J Neurophysiol 40:1325–1338
Lechner SG, Lewin GR (2013) Hairy sensation. Physiology (Bethesda) 28:142–150. doi:10.1152/physiol.00059.2012
Li L, Rutlin M, Abraira VE et al (2011) The functional organization of cutaneous low-threshold mechanosensory neurons. Cell 147:1615–1627. doi:10.1016/j.cell.2011.11.027
Light AR, Trevino DL, Perl ER (1979) Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn. J Comp Neurol 186:151–171. doi:10.1002/cne.901860204
Löken LS, Evert M, Wessberg J (2011) Pleasantness of touch in human glabrous and hairy skin: order effects on affective ratings. Brain Res 1417:9–15. doi:10.1016/j.brainres.2011.08.011
Löken LS, Wessberg J, Morrison I et al (2009) Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci 12:547–548. doi:10.1038/nn.2312
Lumpkin EA, Marshall KL, Nelson AM (2010) The cell biology of touch. J Cell Biol 191:237–248. doi:10.1083/jcb.201006074
Mackevicius EL, Best MD, Saal HP, Bensmaia SJ (2012) Millisecond precision spike timing shapes tactile perception. J Neurosci 32:15309–15317. doi:10.1523/JNEUROSCI.2161-12.2012
Maksimovic S, Nakatani M, Baba Y et al (2014) Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509:617–621. doi:10.1038/nature13250
Maricich SM, Morrison KM, Mathes EL, Brewer BM (2012) Rodents rely on Merkel cells for texture discrimination tasks. J Neurosci 32:3296–3300. doi:10.1523/JNEUROSCI.5307-11.2012
McCabe C, Rolls ET, Bilderbeck A, McGlone F (2008) Cognitive influences on the affective representation of touch and the sight of touch in the human brain. Soc Cogn Affect Neurosci 3:97–108. doi:10.1093/scan/nsn005
McGlone F, Olausson H, Boyle JA et al (2012) Touching and feeling: differences in pleasant touch processing between glabrous and hairy skin in humans. Eur J Neurosci 35:1782–1788. doi:10.1111/j.1460-9568.2012.08092.x
McGlone F, Wessberg J, Olausson H (2014) Discriminative and affective touch: sensing and feeling. Neuron 82:737–755. doi:10.1016/j.neuron.2014.05.001
Miller M, Ralston HI, Kasahara M (1958) The pattern of cutaneous innervation of the human hand. Am J Anat 102:183–217
Mountcastle VB (1957) Modality and topographic properties of single neurons of cat’s somatic sensory cortex. J Neurophysiol 20:408–434
Murray EA, Mishkin M (1984) Relative contributions of SII and area 5 to tactile discrimination in monkeys. Behav Brain Res 11:67–83
Murray GM, Zhang HQ, Kaye AN et al (1992) Parallel processing in rabbit first (SI) and second (SII) somatosensory cortical areas: effects of reversible inactivation by cooling of SI on responses in SII. J Neurophysiol 68:703–710
Nordin M (1990) Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J Physiol 426:229–240
Ochoa J, Mair WG (1969) The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol 13:197–216
Ochoa J, Torebjörk E (1989) Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J Physiol 415:583–599
Olausson H, Lamarre Y, Backlund H et al (2002) Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci 5:900–904. doi:10.1038/nn896
Olausson HW, Cole J, Vallbo A et al (2008) Unmyelinated tactile afferents have opposite effects on insular and somatosensory cortical processing. Neurosci Lett 436:128–132. doi:10.1016/j.neulet.2008.03.015
Padberg J, Recanzone G, Engle J et al (2010) Lesions in posterior parietal area 5 in monkeys result in rapid behavioral and cortical plasticity. J Neurosci 30:12918–12935. doi:10.1523/JNEUROSCI.1806-10.2010
Paré M, Behets C, Cornu O (2003) Paucity of presumptive ruffini corpuscles in the index finger pad of humans. J Comp Neurol 456:260–266. doi:10.1002/cne.10519
Pasalar S, Ro T, Beauchamp MS (2010) TMS of posterior parietal cortex disrupts visual tactile multisensory integration. Eur J Neurosci 31:1783–1790. doi:10.1111/j.1460-9568.2010.07193.x
Penfield W, Boldrey E (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60:389–443. doi:10.1093/brain/60.4.389
Petit D, Burgess PR (1968) Dorsal column projection of receptors in cat hairy skin supplied by myelinated fibers. J Neurophysiol 31:849–855
Pruszynski JA, Johansson RS (2014) Edge-orientation processing in first-order tactile neurons. Nat Neurosci 17:1404–1409. doi:10.1038/nn.3804
Randolph M, Semmes J (1974) Behavioral consequences of selective subtotal ablations in the postcentral gyrus ofMacaca mulatta. Brain Res 70:55–70. doi:10.1016/0006-8993(74)90211-X
Rasmussen T, Penfield W (1947) The human sensorimotor cortex as studied by electrical stimulation. Fed Proc 6:184
Rolls ET, O’Doherty J, Kringelbach ML et al (2003) Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cereb Cortex 13:308–317
Romo R, Hernández A, Zainos A et al (2002a) Exploring the cortical evidence of a sensory-discrimination process. Philos Trans R Soc Lond B Biol Sci 357:1039–1051. doi:10.1098/rstb.2002.1100
Romo R, Hernández A, Zainos A et al (2002b) Neuronal correlates of decision-making in secondary somatosensory cortex. Nat Neurosci 5:1217–1225. doi:10.1038/nn950
Rowe MJ, Turman AB, Murray GM, Zhang HQ (1996) Parallel organization of somatosensory cortical areas I and II for tactile processing. Clin Exp Pharmacol Physiol 23:931–938
Sanchez-Panchuelo RM, Besle J, Beckett A et al (2012) Within-digit functional parcellation of Brodmann areas of the human primary somatosensory cortex using functional magnetic resonance imaging at 7 tesla. J Neurosci 32:15815–15822. doi:10.1523/JNEUROSCI.2501-12.2012
Schlake T (2007) Determination of hair structure and shape. Semin Cell Dev Biol 18:267–273. doi:10.1016/j.semcdb.2007.01.005
Schmidt R, Schmelz M, Forster C et al (1995) Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 15:333–341
Schwartz GG, Rosenblum LA (1981) Allometry of primate hair density and the evolution of human hairlessness. Am J Phys Anthropol 55:9–12. doi:10.1002/ajpa.1330550103
Semba K, Masarachia P, Malamed S et al (1985) An electron microscopic study of terminals of rapidly adapting mechanoreceptive afferent fibers in the cat spinal cord. J Comp Neurol 232:229–240. doi:10.1002/cne.902320208
Semba K, Masarachia P, Malamed S et al (1983) An electron microscopic study of primary afferent terminals from slowly adapting type I receptors in the cat. J Comp Neurol 221:466–481. doi:10.1002/cne.902210409
Semba K, Masarachia P, Malamed S et al (1984) Ultrastructure of pacinian corpuscle primary afferent terminals in the cat spinal cord. Brain Res 302:135–150
Serra J, Campero M, Ochoa J, Bostock H (1999) Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin. J Physiol 515:799–811
St John Smith E, Purfürst B, Grigoryan T et al (2012) Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae. J Comp Neurol 520:2785–2803. doi:10.1002/cne.23133
Stark B, Carlstedt T, Hallin RG, Risling M (1998) Distribution of human pacinian corpuscles in the hand a cadaver study. J Hand Surg Am 23B:370–372
Sugiura Y (1996) Spinal organization of C-fiber afferents related with nociception or non-nociception. Prog Brain Res 113:320–339
Trulsson M (2001) Mechanoreceptive afferents in the human sural nerve. Exp Brain Res 137:111–116. doi:10.1007/s002210000649
Trulsson M, Essick GK (1997) Low-threshold mechanoreceptive afferents in the human lingual nerve. J Neurophysiol 77:737–748
Trulsson M, Essick GK (2010) Sensations evoked by microstimulation of single mechanoreceptive afferents innervating the human face and mouth. J Neurophysiol 103:1741–1747. doi:10.1152/jn.01146.2009
Usoskin D, Furlan A, Islam S et al (2014) Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci 18:145–153. doi:10.1038/nn.3881
Vallbo Å, Hagbarth K (1968) Activity from skin mechanoreceptors recorded percutaneously in awake human subjects. Exp Neurol 289:270–289
Vallbo Å, Olausson H, Wessberg J (1999) Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin. J Neurophysiol 81:2753–2763
Vallbo A, Olausson H, Wessberg J, Norrsell U (1993) A system of unmyelinated afferents for innocuous mechanoreception in the human skin. Brain Res 628:301–304
Vallbo AB, Hagbarth K-E, Wallin BG (2004) Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system. J Appl Physiol 96:1262–1269. doi:10.1152/japplphysiol.00470.2003
Vallbo AB, Johansson RS (1984) Properties of cutaneous mechanoreceptors in the human hand related to touch sensation. Hum Neurobiol 3:3–14
Vallbo AB, Olausson H, Wessberg J, Kakuda N (1995) Receptive field characteristics of tactile units with myelinated afferents in hairy skin of human subjects. J Physiol 483:783–795
Wall PD (1970) The sensory and motor role of impulses travelling in the dorsal columns towards cerebral cortex. Brain 93:505–524
Wall PD, Noordenbos W (1977) Sensory functions which remain in man after complete transection of dorsal columns. Brain 100:641–653
Weber AI, Saal HP, Lieber JD et al (2013) Spatial and temporal codes mediate the tactile perception of natural textures. Proc Natl Acad Sci U S A 110:17107–17112. doi:10.1073/pnas.1305509110
Weddell G, Pallie W, Palmer E (1954) The morphology of peripheral nerve terminations in the skin. Q J Microsc Sci 95:483–501
Wegner K, Forss N, Salenius S (2000) Characteristics of the human contra-versus ipsilateral SII cortex. Clin Neurophysiol 111:894–900
Weidner C, Schmelz M, Schmidt R et al (1999) Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci 19:10184–10190
Weinstein S (1968) Intensive and extensive aspects of tactile sensitivity as a function of body part, sex and laterality. In: Kenshalo D (ed) The skin senses. Charles C. Thomas, Springfield, pp 192–222
Wessberg J, Olausson H, Fernström KW, Vallbo AB (2003) Receptive field properties of unmyelinated tactile afferents in the human skin. J Neurophysiol 89:1567–1575. doi:10.1152/jn.00256.2002
Woo S-H, Ranade S, Weyer AD et al (2014) Piezo2 is required for Merkel-cell mechanotransduction. Nature 509(7502):622–626. doi:10.1038/nature13251
Zhang HQ, Murray GM, Turman AB et al (1996) Parallel processing in cerebral cortex of the marmoset monkey: effect of reversible SI inactivation on tactile responses in SII. J Neurophysiol 76:3633–3655
Zhang HQ, Zachariah MK, Coleman GT, Rowe MJ (2001) Hierarchical equivalence of somatosensory areas I and II for tactile processing in the cerebral cortex of the marmoset monkey. J Neurophysiol 85:1823–1835
Zimmerman A, Bai L, Ginty DD (2014) The gentle touch receptors of mammalian skin. Science 346(6212):950–954. doi:10.1126/science.1254229
Zotterman Y (1939) Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves. J Physiol 95:1–28
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Ackerley, R., Wasling, H.B., McGlone, F. (2016). The Touch Landscape. In: Olausson, H., Wessberg, J., Morrison, I., McGlone, F. (eds) Affective Touch and the Neurophysiology of CT Afferents. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6418-5_6
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