Brain Processing of CT-Targeted Stimulation

  • Malin BjörnsdotterEmail author


CT afferents, together with other types of unmyelinated and thinly myelinated afferents, likely project via the spinothalamic tract to a specific posterior/basal ventral medial nucleus of the thalamus in primates. Functional imaging studies in patients with selective denervation of unmyelinated or myelinated afferents and in healthy subjects suggest that CT-targeted stimulation activates the insular cortex in the hemisphere contralateral to stimulation. This area shows a somatotopical response to CT stimulation, supporting the idea that it is a primary cortical target for CT afferent projections. This chapter reviews findings related to the insular cortex.


fMRI MRI Brain Insular cortex 


  1. Andrew D (2010) Quantitative characterization of low-threshold mechanoreceptor inputs to lamina I spinoparabrachial neurons in the rat. J Physiol 588:117–124CrossRefPubMedGoogle Scholar
  2. Apkarian AV, Bushnell MC, Treede R-D, Zubieta J-K (2005) Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9:463–484CrossRefPubMedGoogle Scholar
  3. Augustine JR (1985) The insular lobe in primates including humans. Neurol Res 7:2–10CrossRefPubMedGoogle Scholar
  4. Baumgärtner U, Iannetti GD, Zambreanu L, Stoeter P, Treede R-D, Tracey I (2010) Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiol 104:2863–2872CrossRefPubMedPubMedCentralGoogle Scholar
  5. Björnsdotter M, Löken L, Olausson H, Vallbo A, Wessberg J (2009) Somatotopic organization of gentle touch processing in the posterior insular cortex. J Neurosci 29:9314–9320CrossRefPubMedGoogle Scholar
  6. Brooks JCW, Zambreanu L, Godinez A, Craig ADB, Tracey I (2005) Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage 27:201–209CrossRefPubMedGoogle Scholar
  7. Craig AD (2002) How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3:655–666CrossRefPubMedGoogle Scholar
  8. Craig ADB (2009) How do you feel—now? The anterior insula and human awareness. Nat Rev Neurosci 10:59–70CrossRefPubMedGoogle Scholar
  9. Craig ADB (2011) Significance of the insula for the evolution of human awareness of feelings from the body. Ann N Y Acad Sci 1225:72–82CrossRefPubMedGoogle Scholar
  10. Craig AD, Chen K, Bandy D, Reiman EM (2000) Thermosensory activation of insular cortex. Nat Neurosci 3:184–190CrossRefPubMedGoogle Scholar
  11. Forget R, Lamarre Y (1995) Postural adjustments associated with different unloadings of the forearm: effects of proprioceptive and cutaneous afferent deprivation. Can J Physiol Pharmacol 73:285–294CrossRefPubMedGoogle Scholar
  12. Henderson LA, Gandevia SC, Macefield VG (2007) Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI study. Pain 128:20–30CrossRefPubMedGoogle Scholar
  13. Henderson LA, Rubin TK, Macefield VG (2011) Within-limb somatotopic representation of acute muscle pain in the human contralateral dorsal posterior insula. Hum Brain Mapp 32:1592–1601CrossRefPubMedGoogle Scholar
  14. Hua LH, Strigo IA, Baxter LC, Johnson SC, Craig ADB (2005) Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex. Am J Physiol Regul Integr Comp Physiol 289:R319–R325CrossRefGoogle Scholar
  15. Kurth F, Eickhoff SB, Schleicher A, Hoemke L, Zilles K, Amunts K (2010) Cytoarchitecture and probabilistic maps of the human posterior insular cortex. Cereb Cortex 20:1448–1461CrossRefPubMedGoogle Scholar
  16. Liljencrantz J, Björnsdotter M, Morrison I, Bergstrand S, Ceko M, Seminowicz DA, Cole J, Bushnell MC, Olausson H (2013) Altered C-tactile processing in human dynamic tactile allodynia. Pain 154:227–234CrossRefPubMedGoogle Scholar
  17. Löken LS, Wessberg J, Morrison I, McGlone F, Olausson H (2009) Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci 12:547–548CrossRefPubMedGoogle Scholar
  18. Mazzola L, Isnard J, Peyron R, Guénot M, Mauguière F (2009) Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain 146:99–104CrossRefPubMedGoogle Scholar
  19. Morrison I, Björnsdotter M, Olausson H (2011a) Vicarious responses to social touch in posterior insular cortex are tuned to pleasant caressing speeds. J Neurosci 31:9554–9562CrossRefPubMedGoogle Scholar
  20. Morrison I, Löken LS, Minde J, Wessberg J, Perini I, Nennesmo I, Olausson H (2011b) Reduced C-afferent fibre density affects perceived pleasantness and empathy for touch. Brain 134:1116–1126CrossRefPubMedGoogle Scholar
  21. Olausson H, Lamarre Y, Backlund H, Morin C, Wallin BG, Starck G, Ekholm S, Strigo I, Worsley K, Vallbo AB et al (2002) Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci 5:900–904CrossRefPubMedGoogle Scholar
  22. Olausson HW, Cole J, Vallbo A, McGlone F, Elam M, Krämer HH, Rylander K, Wessberg J, Bushnell MC (2008) Unmyelinated tactile afferents have opposite effects on insular and somatosensory cortical processing. Neurosci Lett 436:128–132CrossRefPubMedGoogle Scholar
  23. Ostrowsky K, Isnard J, Ryvlin P, Guénot M, Fischer C, Mauguière F (2000) Functional mapping of the insular cortex: clinical implication in temporal lobe epilepsy. Epilepsia 41:681–686CrossRefPubMedGoogle Scholar
  24. Ostrowsky K, Magnin M, Ryvlin P, Isnard J, Guenot M, Mauguière F (2002) Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb Cortex 12:376–385CrossRefPubMedGoogle Scholar
  25. Penfield W, Faulk ME Jr (1955) The insula; further observations on its function. Brain 78:445–470CrossRefPubMedGoogle Scholar
  26. Stephani C, Fernandez-Baca Vaca G, Maciunas R, Koubeissi M, Lüders HO (2011) Functional neuroanatomy of the insular lobe. Brain Struct Funct 216:137–149CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Clinical and Experimental MedicineCenter for Social and Affective Neuroscience, Linköping UniversityLinköpingSweden

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