Abstract
Discoidin domain receptors (DDRs) are evolutionary conserved and found in the genomes of all but the simplest metazoans. DDRs have neither been completely lost in larger animal phyla nor expanded beyond a small number of family members. Currently insights into the function of invertebrate DDRs come mainly from studies in Caenorhabditis elegans, which has two DDR genes similar to vertebrates. C. elegans ddr-2 is required for proper navigation of neuronal processes (axons) during nervous system development. In ddr-2 mutants, axonal navigation in several longitudinal axon tracts is affected, most notably in the ventral nerve cord, the major longitudinal axon tract. ddr-1 mutants alone do not have any obvious axon navigation defects, but various defects seen in ddr-2 mutants are substantially enhanced in ddr-1 ddr-2 double mutants, suggesting a role for both DDRs in axonal navigation. Transcriptional GFP-reporter constructs for ddr-1 and ddr-2 are expressed in neurons with axons in the affected nerve tracts and DDR::GFP fusion proteins localize to axons, raising the possibility that DDRs act as receptors in neurons during axonal outgrowth. These recent studies provide first insights into DDR function in invertebrates and establish a novel role for DDRs in axonal navigation.
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Unsoeld, T., Taylor, J., Hutter, H. (2016). Discoidin Domain Receptors in Invertebrates. In: Fridman, R., Huang, P. (eds) Discoidin Domain Receptors in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6383-6_5
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