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DDR Structural Biology

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Discoidin Domain Receptors in Health and Disease

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Abstract

Discoidin domain receptors (DDRs) are a unique class of receptor tyrosine kinases that is activated by fibrillar collagen. DDR1 and DDR2, the two DDR family isoforms, are single-pass transmembrane proteins, containing the discoidin (DS) domain and the DS-like domain on the extracellular side, and an extremely long juxtamembrane region and the kinase domain on the intracellular side. This chapter provides an overview of the structural knowledge of the DDR receptors.

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Author information

Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan

    Noritaka Nishida & Ichio Shimada

Authors
  1. Noritaka Nishida
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  2. Ichio Shimada
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Corresponding author

Correspondence to Ichio Shimada .

Editor information

Editors and Affiliations

  1. Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA

    Rafael Fridman

  2. Division of Cancer Biology, The Institute of Cancer Research, London, United Kingdom

    Paul H. Huang

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Nishida, N., Shimada, I. (2016). DDR Structural Biology. In: Fridman, R., Huang, P. (eds) Discoidin Domain Receptors in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6383-6_3

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