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Mislocalization of Mitochondrial Intermembrane Space Proteins

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Mitochondria and Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

In this chapter, we describe the unique properties of the mitochondrial intermembrane space (IMS) and its role in apoptosis signalling. We delineate the current models of mitochondrial outer membrane permeabilization (MOMP) during apoptosis and highlight the role of single cell imaging studies in understanding the kinetics of this process. Finally, we will discuss the individual IMS proteins that are released during MOMP and their respective role in the initiation of caspase-dependent and caspase-independent apoptosis.

Author contributed equally with all other contributors.

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Abbreviations

Apaf-1:

Apoptotic protease-activating factor 1

ATP:

Adenosine 5′-(tetrahydrogen triphosphate)

Bcl-2:

B-cell lymphoma-2

CARD:

Caspase recruitment domain

CASPASE:

Cysteinyl aspartate-specific proteinase

cFLIP:

Cellular FLICE-like inhibitory protein

CHX:

Cycloheximide

c-IAP1:

Cellular-inhibitor of apoptosis 1

c-IAP2:

Cellular-inhibitor of apoptosis 2

Cyt-c:

Cytochrome-c

dATP:

Deoxyadenosine 5′-(tetrahydrogen triphosphate)

DD:

Death domain

DED:

Death effector domin

DISC:

Death-inducing signaling complex

FADD:

Fas-associated protein with death domain

FasL:

Fas ligand

FITC:

Fluorescein isothiocyanate

FLIP:

FLICE-like inhibitory protein

GFP:

Green fluorescent protein

IAP:

Inhibitor of apoptosis protein

ICAD:

Inhibitor of caspase-activated DNase

IMS:

Intermembrane space

kDa:

Kilodaltons

MOMP:

Mitochondrial outer membrane permeabilization

PARP:

Poly(ADP-ribose) polymerase

siRNA:

Small interfering RNA

Smac:

Second mitochondria-derived activator of caspases

TNF-α:

Tumor necrosis factor-alpha

TNFR:

Tumor necrosis factor receptor

TRADD:

TNF receptor-associated death domain protein

TRAIL:

Tumor necrosis factor-related apoptosis-inducing ligand

XIAP:

x-Linked inhibitor of apoptosis protein

YFP:

Yellow fluorescent protein

Z-VAD:

Benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fmk

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    1. Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland

      Lorna Flanagan, Federico Lucantoni & J. H. M. Prehn

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    Flanagan, L., Lucantoni, F., Prehn, J.H.M. (2016). Mislocalization of Mitochondrial Intermembrane Space Proteins. In: Hockenbery, D. (eds) Mitochondria and Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3612-0_3

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