Abstract
This chapter reviews the pathophysiological basis of the non-gap metabolic acidoses from the perspective of derangements in the numerous adaptive mechanisms that maintain acid–base balance in the face of daily acid loads from exogenous sources, such as the typical Western diet, and endogenously, from acid products of metabolism. The several causes of non-gap metabolic acidosis are reviewed within this framework as a means of linking the pathophysiology of each disorder to more detailed review of the differential diagnosis, appropriate laboratory tests and recommended treatment that follows in subsequent chapters. The chapter reveals that the pathogenesis of each disorder is quite unique, thus aiding the student in developing a better foundation so that diagnosis and treatment can be considered comprehensively.
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DuBose, T.D. (2016). Etiologic Causes of Metabolic Acidosis II: Normal Anion Gap Acidoses. In: E. Wesson, D. (eds) Metabolic Acidosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3463-8_4
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DOI: https://doi.org/10.1007/978-1-4939-3463-8_4
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