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Differential Diagnosis of Neuroendocrine Tumors

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Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances

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Abstract

Neuroendocrine tumor (NET) arises at multiple sites in the gastrointestinal (GI) tract; in fact GI tract is among the most common sites for NET in human. GI NET may present as well-differentiated neoplasms, further classified in grade 1 and grade 2 depending on the presence or absence of necrosis and on mitotic activity; or they may present as grade 3 neuroendocrine carcinomas which include large cell and small cell carcinoma. This chapter will be focusing on differentiating neuroendocrine neoplasms from other types of morphologically similar neoplasms encountered in daily practice, predominantly those encountered in the GI tract.

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Abbreviations

NET Neuroendocrine tumor

NEC Neuroendocrine carcinoma

NSE Neuron-specific enolase

GI Gastrointestinal

SCC Small cell carcinoma

LCNEC Large-cell neuroendocrine carcinoma

MANEC Mixed adenoneuroendocrine carcinoma

SPN Solid pseudopapillary neoplasm

Author information

Authors and Affiliations

  1. Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA

    Kun Jiang MD, PHD

  2. Department of Oncologic Science, University of South Florida, Tampa, FL, 33612, USA

    Kun Jiang MD, PHD

  3. Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL, USA

    Domenico Coppola MD

Authors
  1. Kun Jiang MD, PHD
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  2. Domenico Coppola MD
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Corresponding author

Correspondence to Kun Jiang MD, PHD .

Editor information

Editors and Affiliations

  1. Diagnostic & Experimental Pathology Lilly Res Laboratories, Eli Lilly & Co., Indianapolis, Indiana, USA

    Aejaz Nasir

  2. H. Lee Moffitt Cancer Ctr & Res, University of South Florida, Tampa, Florida, USA

    Domenico Coppola

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Jiang, K., Coppola, D. (2016). Differential Diagnosis of Neuroendocrine Tumors. In: Nasir, A., Coppola, D. (eds) Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3426-3_3

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  • DOI: https://doi.org/10.1007/978-1-4939-3426-3_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-3424-9

  • Online ISBN: 978-1-4939-3426-3

  • eBook Packages: MedicineMedicine (R0)

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