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Ion Channels and Transporters of Epithelia in Health and Disease pp 725–745Cite as

Orai Channels

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Part of the book series: Physiology in Health and Disease ((PIHD))

Abstract

The highly calcium-selective ion channels formed by the Orai proteins represent the principal route for the agonist-induced entry of extracellular calcium necessary for the generation of the calcium signals involved in the initiation and regulation of a multitude of diverse responses in non-excitable cells. In marked contrast to the voltage-gated calcium channels of excitable cells, the molecular components of these channels (the Orai proteins) and their activation and regulation were only identified less than 10 years ago. Consequently, we are just beginning to understand the details of their unique biophysical properties, modes of activation, and functional roles.

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Acknowledgments

The studies reported here from the author’s laboratory were supported by NIH grant GM040557 to TJS. The excellent technical assistance of Ms. Jill Thompson is also acknowledged.

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Authors and Affiliations

  1. Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA

    Trevor J. Shuttleworth

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  1. Trevor J. Shuttleworth
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Correspondence to Trevor J. Shuttleworth .

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Editors and Affiliations

  1. Department of Physiology, University of Otago , Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Daniel C Devor

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Shuttleworth, T.J. (2016). Orai Channels. In: Hamilton, K., Devor, D. (eds) Ion Channels and Transporters of Epithelia in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3366-2_22

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