Abstract
The maintenance of electrolyte balance is essential for the control of many functions in the human body. Na+, K+, and Cl− are key electrolytes that contribute to a variety of processes ranging from the maintenance of cellular membrane potential to the regulation of cell volume and extracellular fluid volume. Fundamentals of epithelial Cl− and K+ transport are discussed in the preceding and following chapters and will be only briefly touched upon here. Na+ absorption occurs across the epithelial barriers of many organs, including the lung, gastrointestinal tract, exocrine glands, and kidney. Na+ is the primary determinant of blood volume, and a number of physiological mechanisms that control blood pressure mediate their effects by adjusting Na+ balance in the kidney. This chapter describes classical fundamentals of epithelial Na+ absorption and highlights some recent mechanisms involved in physiological regulation of Na+ transport in specific epithelia with a particular emphasis on the kidney.
Keywords
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Acknowledgments
Research from the authors’ laboratories is supported by NIH grants DK075048 (to K.R.H.) and HL108880 (to A.S.) and a Ben J. Lipps Research Fellowship from the ASN (to D.I).
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Staruschenko, A., Ilatovskaya, D.V., Hallows, K.R. (2016). Fundamentals of Epithelial Na+ Absorption. In: Hamilton, K., Devor, D. (eds) Ion Channels and Transporters of Epithelia in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3366-2_2
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