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Properties and Function of the Solute Carrier 26 Family of Anion Transporters

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Ion Channels and Transporters of Epithelia in Health and Disease

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

The SLC26 family of anion transporters consists of 10 members that display remarkable functional and substrate diversity. Mutations in several members of the family have been identified as causing a variety of human diseases and mouse phenotype when deleted. The family drew the attention and strong interest of epithelial biologist with the identification of the first elusive luminal Cl/HCO3 exchange, which turned to be the third member of the family SLC26A3. Fairly quick, progress since revealed that members of the family transport all halides, NO3 , SO4 2−, oxalate, and formate, among others. Members of the family can be grouped into three subgroups based on substrate selectivity and transport mode: the SO4 2− transporters SLC26A1 and SLC26A2; the anion exchangers 2Cl/1HCO3 SLC26A3, 1Cl/1HCO3 SLC26A4, and 1Cl/2HCO3 SLC26A6; and the Cl channels SLC26A7, SLC26A9, and SLC26A11. This chapter discusses structural features, transport properties, and regulation of the transporters that are essential to understand their functions and roles in human diseases.

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Shcheynikov, N., Ohana, E., Muallem, S. (2016). Properties and Function of the Solute Carrier 26 Family of Anion Transporters. In: Hamilton, K., Devor, D. (eds) Ion Channels and Transporters of Epithelia in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3366-2_14

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