Thyroid Cancer pp 277-280 | Cite as

Fine-Needle Aspiration

Chapter

Abstract

Fine-needle aspiration (FNA) is a quick, valuable, minimally invasive procedure to assess the nature of a thyroidal mass. It should not be confused with “needle biopsy,” which requires a Tru-Cut or Vim-Silverman needle and yields tissue fragments for histologic diagnosis. Details of the FNA technique and the equipment required have been described. Of particular importance is the use of a syringe holder and needles with clear plastic hubs (Oertel, J Clin Endocrinol Metab 80:1467–8, 1995). It is essential to use little or no suction when aspirating the lesions (Oertel, Cytopathology 8:134–8, 1997; Oertel, Diagn Cytopathol 30:295–6, 2004).

Keywords

Fine-needle aspiration FNA specimen On-site evaluation Core needle biopsy 

References

  1. 1.
    Oertel YC. A pathologist’s comments on diagnosis of thyroid nodules by fine needle aspiration. J Clin Endocrinol Metab. 1995;80:1467–8.PubMedGoogle Scholar
  2. 2.
    Oertel YC. Who should perform fine-needle aspirations? Cytopathology. 1997;8:134–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Oertel YC. Emerging role of the interventional pathologist. Diagn Cytopathol. 2004;30:295–6.CrossRefPubMedGoogle Scholar
  4. 4.
    American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26:1–133.Google Scholar
  5. 5.
    Moon HJ, Kwak JY, Kim EK, Kim MJ. Ultrasonographic characteristics predictive of nondiagnostic results for fine-needle aspiration biopsies of thyroid nodules. Ultrasound Med Biol. 2011;37:549–55.CrossRefPubMedGoogle Scholar
  6. 6.
    Cappelli C; Pirola I; Gandossi E; De Martino E; Agosti B; Castellano M. Fine-needle aspiration cytology of thyroid nodule: does the needle matter? Southern Medical Journal. 2009;102:498–501.Google Scholar
  7. 7.
    Carpi A, Di Coscio G, Iervasi G, Antonelli A, Mechanick J, Sciacchitano S, Nicolini A. Thyroid fine needle aspiration: how to improve clinicians’ confidence and performance with the technique. Cancer Lett. 2008;264:163–71.CrossRefPubMedGoogle Scholar
  8. 8.
    Carpi A, Ferrari E, Sagripanti A, Nicolini A, Iervasi G, De Gaudio C, Romani R, Di Coscio G. Aspiration needle biopsy refines preoperative diagnosis of thyroid nodules defined at fine needle aspiration as microfollicular nodule. Biomed Pharmacother. 1996;50:325–8.CrossRefPubMedGoogle Scholar
  9. 9.
    Carpi A, Ferrari E, Toni MG, Sagripanti A, Nicolini A, Di Coscio G. Needle aspiration techniques in preoperative selection of patients with thyroid nodules: a long-term study. J Clin Oncol. 1996;14:1704–12.PubMedGoogle Scholar
  10. 10.
    Pitman MB, Abele J, Ali SZ, Duick D, Elsheikh TM, Jeffrey RB, Powers CN, Randolph G, Renshaw A, Scoutt L. Techniques for thyroid FNA: a synopsis of the National Cancer Institute thyroid fine-needle aspiration state of the science conference. Diagn Cytopathol. 2008;36:407–24.CrossRefPubMedGoogle Scholar
  11. 11.
    Kim MJ, Kim EK, Park SI, Kim BM, Kwak JY, Kim SJ, Youk JH, Park SH. US-guided fine-needle aspiration of thyroid nodules: indications, techniques, results. Radiographics. 2008;28:1869–86. discussion 1887.CrossRefPubMedGoogle Scholar
  12. 12.
    Oertel YC. Fine-needle aspiration and the diagnosis of thyroid cancer. Endocrinol Metab Clin North Am. 1996;25:69–91.CrossRefPubMedGoogle Scholar
  13. 13.
    Baloch ZW, LiVolsi VA. Fine-needle aspiration of the thyroid: today and tomorrow. Best Pract Res. 2008;22:929–39.CrossRefGoogle Scholar
  14. 14.
    Baloch ZW, Tam D, Langer J, Mandel S, LiVolsi VA, Gupta PK. Ultrasound-guided fine-needle aspiration biopsy of the thyroid: role of on-site assessment and multiple cytologic preparations. Diagn Cytopathol. 2000;23:425–9.CrossRefPubMedGoogle Scholar
  15. 15.
    Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol. 2004;30:7–13.CrossRefPubMedGoogle Scholar
  16. 16.
    Malle D, Valeri RM, Pazaitou-Panajiotou K, Kiziridou A, Vainas I, Destouni C. Use of a thin-layer technique in thyroid fine needle aspiration. Acta Cytol. 2006;50:23–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Kini SR, Miller JM, Hamburger JI. Cytopathology of thyroid nodules. Henry Ford Hosp Med J. 1982;30:17–24.PubMedGoogle Scholar
  18. 18.
    Oertel YC, Burman K, Boyle L, Ringel M, Wartofsky L, Shmookler B, Yeganeh F, Van Nostrand D. Integrating fine-needle aspiration into a daily practice involving thyroid disorders: the Washington Hospital Center approach. Diagn Cytopathol. 2002;27:120–2.CrossRefPubMedGoogle Scholar
  19. 19.
    Hamburger JI. Fine needle biopsy diagnosis of thyroid nodules. Perspective. Thyroidology. 1988;1:21–34.PubMedGoogle Scholar
  20. 20.
    Goellner JR, Gharib H, Grant CS, Johnson DA. Fine needle aspiration cytology of the thyroid. Acta Cytol. 1987;31:587–90.PubMedGoogle Scholar
  21. 21.
    Redman R, Zalaznick H, Mazzaferri EL, Massoll NA. The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules. Thyroid. 2006;16:55–60.CrossRefPubMedGoogle Scholar
  22. 22.
    Ghofrani M, Beckman D, Rimm DL. The value of onsite adequacy assessment of thyroid fine-needle aspirations is a function of operator experience. Cancer. 2006;108:110–3.CrossRefPubMedGoogle Scholar
  23. 23.
    Ferraz C, Eszlinger M, Paschke R. Current state and future perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules. J Clin Endocrinol Metab. 2011;96:2016–26.CrossRefPubMedGoogle Scholar
  24. 24.
    Park KT, Ahn SH, Mo JH, Park YJ, do Park J, Choi SI, Park SY. Role of core needle biopsy and ultrasonographic finding in management of indeterminate thyroid nodules. Head Neck. 2011;33:160–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Zhang S, Ivanovic M, Nemcek Jr AA, Defrias DV, Lucas E, Nayar R. Thin core needle biopsy crush preparations in conjunction with fine-needle aspiration for the evaluation of thyroid nodules: a complementary approach. Cancer. 2008;114:512–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania Medical Center, Perelman School of MedicinePhiladelphiaUSA

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