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Obesity and Cancer

  • Chapter
Metabolic Syndrome and Diabetes

Abstract

Obesity is a strong risk factor for multiple types of cancer. The mechanisms underlying this association are multiple and include increased systemic inflammation, increased alterations in the systemic hormonal milieu, and direct paracrine tumor-promoting effects of adipose tissue, adipose tissue stem cells, and mature adipocytes. These complex mechanisms generate a carcinogenic milieu in multiple tissues in obesity.

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Authors and Affiliations

  1. Department of Surgery, University of Michigan, 2210 Taubman Center-5334, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5334, USA

    Robert W. O’Rourke M.D.

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  1. Robert W. O’Rourke M.D.
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Correspondence to Robert W. O’Rourke M.D. .

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Editors and Affiliations

  1. Department of Surgery, NYU School of Medicine, New York, New York, USA

    Marina Kurian

  2. Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA

    Bruce M. Wolfe

  3. Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA

    Sayeed Ikramuddin

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O’Rourke, R.W. (2016). Obesity and Cancer. In: Kurian, M., Wolfe, B., Ikramuddin, S. (eds) Metabolic Syndrome and Diabetes. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3220-7_8

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  • DOI: https://doi.org/10.1007/978-1-4939-3220-7_8

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