Patients present to the emergency rooms at cancer centers with a wide spectrum of skin diseases. These diseases include drug reactions, primary cutaneous infections, inflammatory skin disorders (such as Sweet syndrome), graft-versus-host disease (GVHD), and skin signs of disseminated infections. This chapter covers four skin disorders that each have a high associated morbidity: toxic epidermal necrolysis (TEN), drug hypersensitivity syndrome (now known as drug reaction with eosinophilia and systemic symptoms [DRESS]), necrotizing fasciitis, and cutaneous GVHD. With the exception of GVHD, these disorders occur as frequently in the mildly immunosuppressed host as they do in the severely immunosuppressed.
KeywordsToxic epidermal necrolysis Drug reaction with eosinophilia and systemic signs Cutaneous graft-versus-host disease Necrotizing fasciitis
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