Abstract
The method of Chap. 1 obviously fails for Brownian motion in two-dimensional domains whose boundaries are smooth and reflecting, except for a small absorbing window at the end of a cusp-shaped funnel, as shown in Figs. 1.2(left) and 2.1. The cusp can be formed by a partial block of a planar domain, as shown in the schematic Fig. 2.2(left).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
It is known in partial differential equations theory in higher dimensions that at boundary points where \(\sum _{i,j}\sigma ^{ij}(\boldsymbol{x})\nu ^{i}(\boldsymbol{x})\nu ^{j}(\boldsymbol{x}) = 0\) , boundary conditions can be imposed only at points where \(\boldsymbol{a}(\boldsymbol{x}) \cdot \boldsymbol{\nu }(\boldsymbol{x}) <0\).
Bibliography
Bénichou, O. and R. Voituriez (2008), “Narrow-escape time problem: Time needed for a particle to exit a confining domain through a small window,” Phys. Rev. Lett., 100, 168105.
Berezhkovskii, A.M., A.V. Barzykin, and V.Yu. Zitserman (2009), “Escape from cavity through narrow tunnel,” J. Chem. Phys., 130, 245104.
Borgdorff, A.J. and D. Choquet (2002), “Regulation of AMPA receptor lateral movements,” Nature 417, pp.649–653.
Cheviakov, A., M.J. Ward, and R. Straube (2010), “An asymptotic analysis of the mean first passage time for narrow escape problems: Part II: The sphere,” SIAM Multiscale Modeling and Simulation, 8 (3), 836–870.
Choquet, D. (2010), “Fast AMPAR trafficking for a high-frequency synaptic transmission,” Eur. J. Neurosci. 32, pp.250–260.
Coombs, D., R. Straube, and M. Ward, (2009), “Diffusion on a sphere with localized traps: Mean first passage time, eigenvalue asymptotics, and Fekete points,” SIAM J. Appl. Math., 70 (1), pp. 302–332.
Delgado, M.J., M. Ward, D. Coombs, (2015), “Conditional Mean First Passage Times to Small Traps in a 3-D Domain with a Sticky Boundary: Applications to T Cell Searching Behaviour in Lymph Nodes, SIAM J. Multiscale Analysis and Simulation (in press).
Edidin, M., S.C. Kuo and M.P. Sheetz (1991), “Lateral movements of membrane glycoproteins restricted by dynamic cytoplasmic barriers,” Science 254, pp.1379–1382.
Eisinger, J., J. Flores and W.P. Petersen (1986), “A milling crowd model for local and long-range obstructed lateral diffusion. Mobility of excimeric probes in the membrane of intact erythrocytes,” Biophys J. 49, pp.987–1001.
Fabrikant, V.I. (1989), Applications of Potential Theory in Mechanics, Kluwer, Dodrecht.
Fabrikant, V.I. (1991), Mixed Boundary Value Problems of Potential Theory and Their Applications in Engineering, Kluwer, Dodrecht.
Garabedian, P.R. (1964), Partial Differential Equations, Wiley, NY.
C. Guerrier D. Holcman, The search time to a Ribbon and applications to calcium diffusion near a vesicle at synapses (pre-print).
Grigoriev, I.V., Y.A. Makhnovskii, A.M. Berezhkovskii, and V.Y. Zitserman (2002), “Kinetics of escape through a small hole,” J. Chem. Phys., 116, (22), pp.9574–9577.
Hänggi, P., P. Talkner, and M. Borkovec (1990), “50 years after Kramers ,” Rev. Mod. Phys., 62, pp.251–341.
Holcman, D. and Z. Schuss (2004), “Escape through a small opening: receptor trafficking in a synaptic membrane,” J. Stat. Phys., 117 (5/6), 191–230.
Holcman, D., A. Marchewka and Z. Schuss (2005a), “Survival probability of diffusion with trapping in cellular neurobiology.” Phys. Rev. E, Stat. Nonlin. Soft Matter Phys. 72 (3) 031910.
Holcman, D. and Z. Schuss (2005c), “Stochastic chemical reactions in microdomains,” J. Chem. Phys., 122, 114710.
Holcman, D., N. Hoze, Z. Schuss (2011), “Narrow escape through a funnel and effective diffusion on a crowded membrane,” Phys. Rev. E, 84, 021906.
Holcman, D. and Z. Schuss (2011), “Diffusion laws in dendritic spines,” The Journal of Mathematical Neuroscience, 1 (10), pp.1–14.
Holcman, D. and Z. Schuss (2012a), “Brownian motion in dire straits.” SIAM. J. on Multiscale Modeling and Simulation 10(4), pp.1204–1231.
Holcman, D. and Z. Schuss, “Brownian needle in dire straits: Stochastic motion of a rod in very confined narrow domains.” Phys. Rev. E 85 010103(R) (2012b).
D Holcman, Z Schuss, Time scale of diffusion in molecular and cellular biology, Journal of Physics A: Mathematical and Theoretical 47 (17), 173001 (2014).
Jackson, J.D. (1975), Classical Electrodynamics, 2nd Ed., Wiley, NY.
Kochubey, O., X. Lou, and R. Schneggenburger (2011), “Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large cns synapse,” Trends in Neuroscience 34 (5).
Kolokolnikov, T., M. Titcombe and M.J. Ward (2005), “Optimizing the fundamental Neumann eigenvalue for the Laplacian in a domain with small traps,” European J. Appl. Math., 16, 161–200.
Korkotian, E., D. Holcman and M. Segal (2004), “Dynamic regulation of spine-dendrite coupling in cultured hippocampal neurons,” Euro. J. of Neuroscience, 20 (10), pp.2649–2663.
Kusumi, A., C. Nakada, K. Ritchie, K. Murase, K. Suzuki, H. Murakoshi, R.S. Kasai, J. Kondo, T. Fujiwara (2005), “Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules,” Annu Rev Biophys Biomol Struct. 34, pp.351–378.
Kusumi, A., Y. Sako and M. Yamamoto (1993), “Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells,” Biophys J. 65, pp.2021–2040.
Reingruber, J. and D. Holcman (2011b), “The narrow escape problem in a flat cylindrical microdomain with application to diffusion in the synaptic cleft.” Multiscale Model. Simul. 9 (2), pp.793–816.
Saxton, M.J. (1995), “Single-particle tracking: effects of corrals,” Biophys. J. 69, pp.389–398.
Saxton, M.J. and K. Jacobson (1997), “Single-particle tracking: applications to membrane dynamics,” Annu. Rev. Biophys. Biomol. Struct. 26, pp.373–399.
Schuss, Z., A. Singer, and D. Holcman (2007), “The narrow escape problem for diffusion in cellular microdomains,” Proc. Natl. Acad. Sci. USA, 104, 16098–16103.
Schuss, Z. (2010a), “Equilibrium and recrossings of the transition state: what can be learned from diffusion?” J. Phys. Chem. C, 114 (48), pp.20320–20334.
Schuss, Z. (2010b), Theory and Applications of Stochastic Processes, and Analytical Approach, Springer series on Applied Mathematical Sciences 170, NY.
Schuss, Z.(2013) Brownian Dynamics at Boundaries and Interfaces in Physics, Chemistry, and Biology, Springer series on Applied Mathematical Sciences, NY.
Sheetz, M.P. (1993), “Glycoprotein motility and dynamic domains in fluid plasma membranes,” Ann. Rev. Biophys. Biomol. Struct. 22, pp.417–431.
Singer, A., Z. Schuss, D. Holcman, and R.S. Eisenberg (2006a), “Narrow escape, Part I,” J. Stat. Phys., 122 (3), pp.437–463.
Singer, A., Z. Schuss, and D. Holcman (2006b), “Narrow escape, Part II: The circular disk,” J. Stat. Phys., 122 (3), pp.465–489.
Singer, A., Z. Schuss, and D. Holcman (2006c), “Narrow escape, Part III: Non-smooth domains and Riemann surfaces,” J. Stat. Phys., 122 (3), pp.491–509.
Singer, A. and Z. Schuss (2006), “Activation through a narrow opening,” Phys. Rev. E (Rapid Comm.), 74, 020103(R).
Singer, A. Z. Schuss, A. Osipov, and D. Holcman (2008b), “Partially Reflected Diffusion” SIAM J. Appl. Math. 68, pp.844–868.
Sneddon, I.N. (1966), Mixed Boundary Value Problems in Potential Theory, Wiley, NY.
Suzuki, K. and M.P. Sheetz (2001), “Binding of cross-linked glycosylphosphatidyl-inositol-anchored proteins to discrete actin-associated sites and cholesterol-dependent domains,” Biophys. J. 81, pp.2181–2189.
Taflia, A. and D. Holcman (2007), “Dwell time of a molecule in a microdomain,” J. Chem. Phys. 126, (23) 234107.
Taflia, A. and D. Holcman (2011), “Estimating the synaptic current in a multiconductance AMPA receptor model.” Biophys. J. 101 (4), pp.781–792.
Tardin, C., L. Cognet, C. Bats, B. Lounis, and D. Choquet (2003), “Direct imaging of lateral movements of AMPA receptors inside synapses,” Embo J. 22, pp.4656–4665.
Triller, A. and D. Choquet (2003), “The role of receptor diffusion in the organization of the postsynaptic membrane,” Nat. Rev. Neurosci., 4, pp.1251–1265.
Ward, M.J. and E. Van De Velde (1992), “The onset of thermal runaway in partially insulated or cooled reactors,” IMA J. Appl. Math., 48, 53–85.
Ward, M.J. and J.B. Keller (1993), “Strong localized perturbations of eigenvalue problems,” SIAM J. Appl. Math., 53, pp.770–798.
Ward, M.J., W.D. Henshaw, and J.B. Keller (1993), “Summing logarithmic expansions for singularly perturbed eigenvalue problems,” SIAM J. Appl. Math., 53, pp.799–828.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Holcman, D., Schuss, Z. (2015). Special Asymptotics for Stochastic Narrow Escape. In: Stochastic Narrow Escape in Molecular and Cellular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3103-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-3103-3_2
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-3102-6
Online ISBN: 978-1-4939-3103-3
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)