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More than a Scaffold: Extracellular Matrix in Vascular Signaling

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Endothelial Signaling in Development and Disease

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Abstract

Extracellular matrix (ECM), a non-living material that fills the space surrounding the cells, plays critical functions in multicellular organisms. On a macroscopic level, a complex mixture of proteins and polysaccharides organized in fibers and mesh-like structures provides biomechanical support to tissues, and defines organ shape and dimensions. However, on a microscopic level ECM is not just a structural element of the cellular environment but an important communication medium between the cells and their surroundings, as well as between the cells themselves. Physiological processes during embryonic development and in the adult require cells to perform their basic functions, such as survival and death, multiplication and migration, and a complex repertoire of matrix proteins and receptors helps the cells attune to the changes in their local setting. However, ECM is also a dynamic system that undergoes constant remodeling, and when that process goes awry it can promote and facilitate numerous pathological conditions. This chapter will explore how this intricate milieu of structurally and functionally divergent molecules regulates endothelial cell biology in health and disease.

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    Dr Iva Nikolic PhD

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Nikolic, I. (2015). More than a Scaffold: Extracellular Matrix in Vascular Signaling. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_7

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