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Glucocorticoid Signaling pp 33–57Cite as

Molecular Biology of Glucocorticoid Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 872))

Abstract

Well-defined as signaling hormones for the programming of cell type-specific and context-dependent gene expression signatures, glucocorticoids control experience-driven allostasis. One unifying model is that glucocorticoids help maintaining the integrity and plasticity of cellular networks in changing environments through the mobilization of cellular energy stores, profiling of gene expression, and changes in the electrical and morphological properties of cells. The nucleus is their primary site of action, yet recent discoveries point to additional gene transcription-independent functions at the plasma membrane of neuronal synapses. Glucocorticoids are secreted factors that reflect intrinsically the changes coming from the external world, temporally and regionally, during development and adulthood. In this review, we will enumerate the properties and signaling attributes of glucocorticoids and their receptors that characterize them as allostatic modulators. The molecular mechanisms used to support their role at the synapse will be highlighted.

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Acknowledgement

We are thankful to Michael Garabedian (New York University) for support and Inserm’s AVENIR funding program.

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Authors and Affiliations

  1. Inserm U1191, CNRS UMR5203, Institute for Functional Genomics, 141 rue de la Cardonille, Montpellier Cedex 05, 34094, France

    Margarita Arango-Lievano Ph.D. & Freddy Jeanneteau Ph.D.

  2. Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA

    W. Marcus Lambert Ph.D.

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  1. Margarita Arango-Lievano Ph.D.
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  2. W. Marcus Lambert Ph.D.
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  3. Freddy Jeanneteau Ph.D.
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Correspondence to Freddy Jeanneteau Ph.D. .

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  1. Department of Nutritional Science & Toxicology, University of California Berkeley, Berkeley, California, USA

    Jen-Chywan Wang

  2. Division of Endocrinology Metabolism & Lipid Research, Department of Internal Medicine, Washington University School of Medicine Division of Endocrinology, St. Louis, Missouri, USA

    Charles Harris

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Arango-Lievano, M., Lambert, W.M., Jeanneteau, F. (2015). Molecular Biology of Glucocorticoid Signaling. In: Wang, JC., Harris, C. (eds) Glucocorticoid Signaling. Advances in Experimental Medicine and Biology, vol 872. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2895-8_2

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