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Infectious Diseases of the Skin

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Precision Molecular Pathology of Dermatologic Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 9))

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Abstract

Molecular techniques are gaining growing utility in the infectious dermatopathology laboratory. Although culture-based methods are still regarded as the gold standard for diagnosis of most of the infectious diseases of the skin, molecular tests have a great potential due to their high sensitivity and specificity. These methods do not require tissue cultures and can be applied to formalin-fixed paraffin-embedded (FFPE) tissues. Signal amplification methods (in situ hybridization, ISH) and target amplification methods (polymerase chain reaction, PCR) are among the most used molecular biology-based tests in the routine dermatopathology practice. In this chapter, we discussed the application of these methods in the diagnosis of common viral, bacterial, fungal, and parasitic infections of the skin.

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Authors and Affiliations

  1. Departments of Pathology and Dermatology, The University of Texas: MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 85, 77030, Houston, TX, USA

    Carlos A. Torres-Cabala

  2. Department of Pathology and Dermatology, University of Texas: MD Anderson Cancer Center, Houston, TX, USA

    Kudakwashe Mutyambizi

  3. Departments of Pathology and Dermatology, Universidad Peruana Cayetano Heredia, Lima, Peru Houston, USA

    Francisco Bravo

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  1. Carlos A. Torres-Cabala
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  2. Kudakwashe Mutyambizi
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  3. Francisco Bravo
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Correspondence to Carlos A. Torres-Cabala .

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  1. Department of Pathology, University of Texas, MD Anderson Cancer, Houston, Texas, USA

    Victor G. Prieto

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Torres-Cabala, C., Mutyambizi, K., Bravo, F. (2015). Infectious Diseases of the Skin. In: Prieto, V. (eds) Precision Molecular Pathology of Dermatologic Diseases. Molecular Pathology Library, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2861-3_5

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