Skip to main content

Neurogenic Tumors

  • Chapter
  • 1628 Accesses

Part of the book series: Atlas of Anatomic Pathology ((AAP))

Abstract

Neurogenic tumors of the mediastinum are relatively rare and are most often encountered in the pediatric-age population. They most commonly arise from structures in the posterior mediastinum, although they can originate from all three mediastinal compartments. Neurogenic tumors are, in fact, the most common tumors of the posterior mediastinum in both children and adults. Neurogenic tumors can be of neuroblastic origin or may arise from peripheral nerve sheath elements (Table 4.1).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Suggested Reading

  • Adam A, Hochholzer L. Ganglioneuroblastoma of the posterior mediastinum: a clinicopathologic review of 80 cases. Cancer. 1981;47:373–81.

    Article  CAS  PubMed  Google Scholar 

  • Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing’s sarcoma and peripheral primitive neuroectodermal tumor from MIC2 expression and specific chromosomal aberration. Cancer. 1991;67:1886–93.

    Article  CAS  PubMed  Google Scholar 

  • Cardillo G, Carleo F, Khalil MW, Carbone L, Treggiari S, Salvadori L, et al. Surgical treatment of benign neurogenic tumours of the mediastinum: a single institution report. Eur J Cardiothorac Surg. 2008;34:1210–4.

    Article  PubMed  Google Scholar 

  • Carney JA. Psammomatous melanotic schwannoma: a distinctive heritable tumor with special associations, including cardiac myxomas and Cushing’s syndrome. Am J Surg Pathol. 1990;14:206–22.

    Article  CAS  PubMed  Google Scholar 

  • Chalmers AH, Armstrong P. Plexiform mediastinal neurofibromas. A report of two cases. Br J Radiol. 1977;50:215–7.

    Article  CAS  PubMed  Google Scholar 

  • Chatten J, Shimada H, Sather HN, Wong KY, Siegel SE, Hammond GD. Prognostic value of histopathology in advanced neuroblastoma: a report from the Childrens Cancer Study Group. Hum Pathol. 1988;19:1187–8.

    Article  CAS  PubMed  Google Scholar 

  • Dehner LP. Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol. 1993;17:1–13.

    Article  CAS  PubMed  Google Scholar 

  • Cataldo D. Mediastinal ganglioneuroma: a rare and often asymptomatic tumor. Chir Ital. 2005;53:403–5.

    Google Scholar 

  • Ducatman BS, Scheithauer BW, Piepgras BG, Reiman HM, Ilstrup DM. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer. 1986;57:2006–21.

    Article  CAS  PubMed  Google Scholar 

  • Hirschfeld K, Woodward W. Neurofibromata of the anterior mediastinum. Aust N Z J Surg. 1963;33:76–7.

    Article  CAS  PubMed  Google Scholar 

  • Inoue M, Mitsudomi T, Osaki T, Oyama T, Haratake J, Yasumoto K. Malignant transformation of an intrathoracic neurofibroma in von Recklinghausen’s disease. Scand Cardiovasc J. 1998;32:173–5.

    Article  CAS  PubMed  Google Scholar 

  • Johnson MD, Glick AD, Davis BW. Immunohistochemical evaluation of Leu-7, myelin basic protein, S-100 protein, glial fibrillary acidic protein, and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch Pathol Lab Med. 1988;112:155–60.

    CAS  PubMed  Google Scholar 

  • Joshi VV, Cantor AB, Altshuler G, Larkin EW, Neill JS, Shuster JJ, et al. Recommendations for modification of terminology of neuroblastic tumors and prognostic significance of Shimada classification. A clinicopathologic study of 213 cases from the Pediatric Oncology Group. Cancer. 1992;69:2183–96.

    Article  CAS  PubMed  Google Scholar 

  • King RM, Telander RL, Smithson WA, Banks PM, Han MT. Primary mediastinal tumors in children. J Pediatr Surg. 1982;17:512–20.

    Article  CAS  PubMed  Google Scholar 

  • Koezuka S, Hata Y, Sato F, Otsuka H, Makina T, Tochigi N, Iyoda A. Malignant peripheral nerve sheath tumor in the anterior mediastinum: a case report. Mol Clin Oncol. 2014;2:987–90.

    PubMed Central  PubMed  Google Scholar 

  • Manduch M, Dexter DF, Ellis PM, Reid K, Isotalo PA. Extraskeletal Ewing’s sarcoma/primitive neuroectodermal tumor of the posterior mediastinum with t(11;22)(q24;q12). Tumori. 2008;94:888–91.

    PubMed  Google Scholar 

  • Marchevsky AM. Mediastinal tumors of peripheral nervous system origin. Semin Diagn Pathol. 1999;16:65–78.

    CAS  PubMed  Google Scholar 

  • Pekmeczi M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, et al. Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol. 2014. doi:10.1038/modpathol.2014.109. [Epub ahead of print].

    Google Scholar 

  • Schweigert M, Meyer C, Wolf F, Stein HJ. Peripheral primitive neuroectodermal tumor of the thymus. Interact Cardiovasc Thorac Surg. 2011;12:303–5.

    Article  PubMed  Google Scholar 

  • Shields TW, Reynolds M. Neurogenic tumors of the thorax. Surg Clin North Am. 1988;68:645–68.

    CAS  PubMed  Google Scholar 

  • Shirakusa T, Tsutsui M, Montonaga R, Takata S, Yoshomine K, Kondo K, Yoshida T. Intrathoracic tumors arising from the vagus nerve. Review of resected tumors in Japan. Scand J Thorac Cardiovasc Surg. 1989;23:173–5.

    Article  CAS  PubMed  Google Scholar 

  • Steffanson K, Wollmann R, Jerkovic M. S-100 protein in soft tissue tumors derived from schwann cells and melanocytes. Am J Pathol. 1982;106:261–8.

    Google Scholar 

  • Sugio K, Inoue T, Inoue K, Tateishi M, Ishida T, Sugimachi K. Neurogenic tumors of the mediastinum originated from the vagus nerve. Eur J Surg Oncol. 1995;21:214–6.

    Article  CAS  PubMed  Google Scholar 

  • Suster S. Recent advances in the application of immunohistochemical markers for the diagnosis of soft tissue tumors. Semin Diagn Pathol. 2000;17:225–35.

    CAS  PubMed  Google Scholar 

  • Takeda S, Miyoshi S, Minami M, Matsuda H. Intrathoracic neurogenic tumors–50 years’ experience in a Japanese institution. Eur J Cardiothorac Surg. 2004;26:807–12.

    PubMed  Google Scholar 

  • Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL. Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma”. Am J Surg Pathol. 2014;38:94–105.

    Article  PubMed  Google Scholar 

  • Turc-Carel C, Aurias A, Mugneret F, Lizard S, Sidaner I, Volk C, et al. Chromosomes in Ewing’s sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet. 1988;32:229–38.

    Article  CAS  PubMed  Google Scholar 

  • Weitzner S. Adjacent malignant schwannoma and neurofibroma of intrathoracic vagus. Am Surg. 1976;42:866–70.

    CAS  PubMed  Google Scholar 

  • Wick MR, Swanson PE, Scheithauer BW, Manivel JC. Malignant peripheral nerve sheath tumor. An immunohistochemical study of 62 cases. Am J Clin Pathol. 1987;87:425–33.

    CAS  PubMed  Google Scholar 

  • Woodruff JM, Godwin TA, Erlandson RA, Susin M, Martini N. Cellular schwannoma: a variety of schwannoma sometimes mistaken for a malignant tumor. Am J Surg Pathol. 1981;5:733–44.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Suster, S. (2015). Neurogenic Tumors. In: Atlas of Mediastinal Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2674-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-2674-9_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2673-2

  • Online ISBN: 978-1-4939-2674-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics