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Basic Aspects

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Textbook of Personalized Medicine

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Abstract

Most of the current drugs are approved and developed based on their performance in a large population of people but medicine of the future is developing as personalized solutions for a particular patient’s needs. In case of complex disorders, the conventional “one-drug-fits-all” approach involves trial and error before an appropriate treatment is found. Clinical trial data for a new drug merely shows the average response of a study group. There is, however, considerable individual variation; some patients show no response whereas others show a dramatic response. It is obvious that the concept “one medicine for all patients with the same disease” does not hold and a more individualized approach is needed. Although individualization of certain treatments has been carried out in the pregenomic era, the concept of personalized medicine as described in this report follows progress in study of human diseases at molecular level, advances in molecular diagnostics and drug development based on genomics, proteomics, metabolomics and biomarkers. The aim of the personalized medicine is to match the right drug to the right patient and in some cases, even to design the treatment for a patient according to genotype as well as other individual characteristics. A broader term is integrated healthcare, which includes development of genomics-based personalized medicine, predisposition testing, preventive medicine, combination of diagnostics with therapeutics and monitoring of therapy. This fits in with the concept of system biology as applied to healthcare and termed systems medicine.

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Authors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

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  1. Kewal K. Jain
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Jain, K.K. (2015). Basic Aspects. In: Textbook of Personalized Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2553-7_1

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