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Epigenetics of Fungal Secondary Metabolism Related Genes

  • Ming-Yueh Wu
  • Jae-Hyuk YuEmail author
Chapter
Part of the Fungal Biology book series (FUNGBIO)

Abstract

Fungal secondary metabolites play multiple biological roles in development, virulence, defense, adaptation, and stress response. Many of these low-molecular-mass compounds are of intense interest to humankind due to their economic applications (antibiotics and drugs) and/or adverse effects (mycotoxins). Many filamentous fungal secondary metabolites are synthesized by enzymes and related regulator(s) are encoded by clustered genes. Expression of these clusters are governed by various transcription factors and signaling elements. Recent studies have further revealed that fungal secondary metabolite genes are subject to epigenetic regulation. This chapter presents a concise summary of the epigenetic modifications and remodeling of the genes associated with fungal secondary metabolism, focusing on the genetic elements involved in epigenetic regulation, including HepA, (LaeA), complex proteins associated with Set1 (COMPASS) complex, histone deacetylases (HDACs), Spt-Ada-Gcn5-acetyltransferase (SAGA/ADA) complex, and small ubiquitin-like modifier (SUMO). Finally, the current applications of these epigenetic regulators are discussed.

Keywords

Epigenetics Fungi Secondary metabolism Gene Cluster Regulation Chromatin Histone Methylation Acetylation Sumoylation 

Notes

Acknowledgements

We thank Dr. Ellin Doyle for critically reviewing the manuscript. This work was supported by USDA Hatch (WIS01665) and the Intelligent Synthetic Biology Center of Global Frontier Project (2011-0031955) funded by the Ministry of Education, Science and Technology grants to JHY.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Bacteriology and GeneticsUniversity of Wisconsin-MadisonMadisonUSA

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